1EAS | pdb_00001eas

NONPEPTIDIC INHIBITORS OF HUMAN LEUKOCYTE ELASTASE. 3. DESIGN, SYNTHESIS, X-RAY CRYSTALLOGRAPHIC ANALYSIS, AND STRUCTURE-ACTIVITY RELATIONSHIPS FOR A SERIES OF ORALLY ACTIVE 3-AMINO-6-PHENYLPYRIDIN-2-ONE TRIFLUOROMETHYL KETONES

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RCSB PDB Mol* Viewer 2.11.4 [4/4/2025, 6:48:47 PM]
Sequence of
16   ​V​​V​​G​​G​​T​​E​​A​​Q​​R​​N​26   ​S​​W​​P​​S​​Q​​I​​S​​L​​Q​​Y​36   ​R​​S​​G​​S​​S​​W​​A​​H​​T​​C​43   ​G​​G​​T​​L​​I​​R​​Q​​N​​W​​V​53   ​M​​T​​A​​A​​H​​C​​V​​D​​R​​E​63   ​L​​T​​F​​R​​V​​V​​V​​G​​E​​H​72   ​N​​L​​N​​Q​​N​​N​​G​​T​​E​​Q​82   ​Y​​V​​G​​V​​Q​​K​​I​​V​​V​​H​92   ​P​​Y​​W​​N​​T​​D​​D​​V​​A​​A​100  ​G​​Y​​D​​I​​A​​L​​L​​R​​L​​A​110  ​Q​​S​​V​​T​​L​​N​​S​​Y​​V​​Q​120  ​L​​G​​V​​L​​P​​R​​A​​G​​T​​I​130  ​L​​A​​N​​N​​S​​P​​C​​Y​​I​​T​140  ​G​​W​​G​​L​​T​​R​​T​​N​​G​​Q​151  ​L​​A​​Q​​T​​L​​Q​​Q​​A​​Y​​L​161  ​P​​T​​V​​D​​Y​​A​​I​​C​​S​​S​170A ​S​​S​​Y​​W​​G​​S​​T​​V​​K​​N​179  ​S​​M​​V​​C​​A​​G​​G​​D​​G​​V​188A ​R​​S​​G​​C​​Q​​G​​D​​S​​G​​G​198  ​P​​L​​H​​C​​L​​V​​N​​G​​Q​​Y​208  ​A​​V​​H​​G​​V​​T​​S​​F​​V​​S​217A ​R​​L​​G​​C​​N​​V​​T​​R​​K​​P​226  ​T​​V​​F​​T​​R​​V​​S​​A​​Y​​I​236  ​S​​W​​I​​N​​N​​V​​I​​A​​S​​N​
Type
Asm Id
Dynamic Bonds

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