2WXK | pdb_00002wxk

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with INK666.

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RCSB PDB Mol* Viewer 2.11.4 [4/4/2025, 6:48:47 PM]
Sequence of
     ​G​​G​​D​​R​​V​​K​​K​​L​​I​​N​115  ​S​​Q​​I​​S​​L​​L​​I​​G​​K​​G​125  ​L​​H​​E​​F​​D​​S​​L​​R​​D​​P​135  ​E​​V​​N​​D​​F​​R​​T​​K​​M​​R​145  ​Q​​F​​C​​E​​E​​A​​A​​A​​H​​R​155  ​Q​​Q​​L​​G​​W​​V​​E​​W​​L​​Q​165  ​Y​​S​​F​​P​​L​​Q​​L​​E​​P​​S​     ​A​​R​​G​​W​​R​​A​​G​​L​​L​​R​     ​V​​S​​N​​R​​A​​L​​L​​V​​N​​V​195  ​K​​F​​E​​G​​S​​E​​E​​S​​F​​T​205  ​F​​Q​​V​​S​​T​​K​​D​​M​​P​​L​215  ​A​​L​​M​​A​​C​​A​​L​​R​​K​​K​225  ​A​​T​​V​​F​​R​​Q​​P​​L​​V​​E​235  ​Q​​P​​E​​E​​Y​​A​​L​​Q​​V​​N​245  ​G​​R​​H​​E​​Y​​L​​Y​​G​​N​​Y​255  ​P​​L​​C​​H​​F​​Q​​Y​​I​​C​​S​265  ​C​​L​​H​​S​​G​​L​​T​​P​​H​​L​275  ​T​​M​​V​​H​​S​​S​​S​​I​​L​​A​285  ​M​​R​​D​​E​​Q​​S​​N​​P​​A​​P​     ​Q​​V​​Q​​K​​P​​R​​A​​K​​P​​P​     ​P​​I​​P​​A​​K​​K​​P​​S​​S​​V​     ​S​​L​​W​​S​​L​​E​​Q​​P​​F​​S​325  ​I​​E​​L​​I​​E​​G​​R​​K​​V​​N​335  ​A​​D​​E​​R​​M​​K​​L​​V​​V​​Q​345  ​A​​G​​L​​F​​H​​G​​N​​E​​M​​L​355  ​C​​K​​T​​V​​S​​S​​S​​E​​V​​N​365  ​V​​C​​S​​E​​P​​V​​W​​K​​Q​​R​375  ​L​​E​​F​​D​​I​​S​​V​​C​​D​​L​385  ​P​​R​​M​​A​​R​​L​​C​​F​​A​​L​395  ​Y​​A​​V​​V​​E​​K​​A​​K​​K​​A​     ​R​​S​​T​​K​​K​​K​​S​​K​​K​​A​415  ​D​​C​​P​​I​​A​​W​​A​​N​​L​​M​425  ​L​​F​​D​​Y​​K​​D​​Q​​L​​K​​T​435  ​G​​E​​R​​C​​L​​Y​​M​​W​​P​​S​445  ​V​​P​​D​​E​​K​​G​​E​​L​​L​​N​455  ​P​​A​​G​​T​​V​​R​​G​​N​​P​​N​465  ​T​​E​​S​​A​​A​​A​​L​​V​​I​​Y​475  ​L​​P​​E​​V​​A​​P​​H​​P​​V​​Y​485  ​F​​P​​A​​L​​E​​K​​I​​L​​E​​L​     ​G​​R​​H​​G​​E​​R​​G​​R​​I​​T​505  ​E​​E​​E​​Q​​L​​Q​​L​​R​​E​​I​515  ​L​​E​​R​​R​​G​​S​​G​​E​​L​​Y​525  ​E​​H​​E​​K​​D​​L​​V​​W​​K​​M​535  ​R​​H​​E​​V​​Q​​E​​H​​F​​P​​E​545  ​A​​L​​A​​R​​L​​L​​L​​V​​T​​K​555  ​W​​N​​K​​H​​E​​D​​V​​A​​Q​​M​565  ​L​​Y​​L​​L​​C​​S​​W​​P​​E​​L​575  ​P​​V​​L​​S​​A​​L​​E​​L​​L​​D​585  ​F​​S​​F​​P​​D​​C​​Y​​V​​G​​S​595  ​F​​A​​I​​K​​S​​L​​R​​K​​L​​T​605  ​D​​D​​E​​L​​F​​Q​​Y​​L​​L​​Q​615  ​L​​V​​Q​​V​​L​​K​​Y​​E​​S​​Y​625  ​L​​D​​C​​E​​L​​T​​K​​F​​L​​L​635  ​G​​R​​A​​L​​A​​N​​R​​K​​I​​G​645  ​H​​F​​L​​F​​W​​H​​L​​R​​S​​E​655  ​M​​H​​V​​P​​S​​V​​A​​L​​R​​F​665  ​G​​L​​I​​M​​E​​A​​Y​​C​​R​​G​675  ​S​​T​​H​​H​​M​​K​​V​​L​​M​​K​685  ​Q​​G​​E​​A​​L​​S​​K​​L​​K​​A​695  ​L​​N​​D​​F​​V​​K​​V​​S​​S​​Q​705  ​K​​T​​T​​K​​P​​Q​​T​​K​​E​​M​715  ​M​​H​​M​​C​​M​​R​​Q​​E​​T​​Y​725  ​M​​E​​A​​L​​S​​H​​L​​Q​​S​​P​735  ​L​​D​​P​​S​​T​​L​​L​​E​​E​​V​745  ​C​​V​​E​​Q​​C​​T​​F​​M​​D​​S​755  ​K​​M​​K​​P​​L​​W​​I​​M​​Y​​S​765  ​S​​E​​E​​A​​G​​S​​A​​G​​N​​V​775  ​G​​I​​I​​F​​K​​N​​G​​D​​D​​L​785  ​R​​Q​​D​​M​​L​​T​​L​​Q​​M​​I​795  ​Q​​L​​M​​D​​V​​L​​W​​K​​Q​​E​805  ​G​​L​​D​​L​​R​​M​​T​​P​​Y​​G​815  ​C​​L​​P​​T​​G​​D​​R​​T​​G​​L​825  ​I​​E​​V​​V​​L​​H​​S​​D​​T​​I​835  ​A​​N​​I​​Q​​L​​N​​K​​S​​N​​M​845  ​A​​A​​T​​A​​A​​F​​N​​K​​D​​A​855  ​L​​L​​N​​W​​L​​K​​S​​K​​N​​P​865  ​G​​E​​A​​L​​D​​R​​A​​I​​E​​E​875  ​F​​T​​L​​S​​C​​A​​G​​Y​​C​​V​885  ​A​​T​​Y​​V​​L​​G​​I​​G​​D​​R​895  ​H​​S​​D​​N​​I​​M​​I​​R​​E​​S​905  ​G​​Q​​L​​F​​H​​I​​D​​F​​G​​H​915  ​F​​L​​G​​N​​F​​K​​T​​K​​F​​G​     ​I​​N​​R​​E​​R​​V​​P​​F​​I​​L​935  ​T​​Y​​D​​F​​V​​H​​V​​I​​Q​​Q​945  ​G​​K​​T​​N​​N​​S​​E​​K​​F​​E​955  ​R​​F​​R​​G​​Y​​C​​E​​R​​A​​Y​965  ​T​​I​​L​​R​​R​​H​​G​​L​​L​​F​975  ​L​​H​​L​​F​​A​​L​​M​​R​​A​​A​985  ​G​​L​​P​​E​​L​​S​​C​​S​​K​​D​995  ​I​​Q​​Y​​L​​K​​D​​S​​L​​A​​L​1005 ​G​​K​​T​​E​​E​​E​​A​​L​​K​​H​1015 ​F​​R​​V​​K​​F​​N​​E​​A​​L​​R​1025 ​E​​S​​W​​K​​T​​K​​V​​N​​W​​L​     ​A​​H​​N​​V​​S​​K​​D​​N​​R​​Q​
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