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3DG8
Quadruple mutant (N51I+C59R+S108N+I164L) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with RJF670, NADPH, and dUMP
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RCSB PDB Mol* Viewer 2.10.6 [10/28/2024, 3:56:31 PM]
Sequence of
1 MMEQVCDVFD11 IYAICACCKV21 ESKNEGKKNE31 VFNNYTFRGL41 GNKGVLPWKC51 ISLDMKYFRA61 VTTYVNESKY71 EKLKYKRCKY81 LNKETVDNVN DMPNSKKLQN101 VVVMGRTNWE111 SIPKKFKPLS121 NRINVILSRT131 LKKEDFDEDV141 YIINKVEDLI151 VLLGKLNYYK161 CFILGGSVVY171 QEFLEKKLIK181 KIYFTRINST191 YECDVFFPEI201 NENEYQIISV211 SDVYTSNNTT221 LDFIIYKKTN231 NKMLNEQNCI KGEEKNNDMP LKNDDKDTCH MKKLTEFYKN VDKYKINYEN
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