3PR0 | pdb_00003pr0

Crystal Structure of a Covalently Bound alpha-Ketoheterocycle Inhibitor (Phenhexyl/Oxadiazole/Pyridine) to a Humanized Variant of Fatty Acid Amide Hydrolase

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Sequence of
     ​M​​G​​S​​S​​H​​H​​H​​H​​H​​H​     ​S​​S​​G​​L​​V​​P​​R​​G​​S​​H​     ​M​​A​​S​​R​​W​​T​​G​​R​​Q​​K​37   ​A​​R​​G​​A​​A​​T​​R​​A​​R​​Q​47   ​K​​Q​​R​​A​​S​​L​​E​​T​​M​​D​57   ​K​​A​​V​​Q​​R​​F​​R​​L​​Q​​N​67   ​P​​D​​L​​D​​S​​E​​A​​L​​L​​T​77   ​L​​P​​L​​L​​Q​​L​​V​​Q​​K​​L​87   ​Q​​S​​G​​E​​L​​S​​P​​E​​A​​V​97   ​F​​F​​T​​Y​​L​​G​​K​​A​​W​​E​107  ​V​​N​​K​​G​​T​​N​​C​​V​​T​​S​117  ​Y​​L​​T​​D​​C​​E​​T​​Q​​L​​S​127  ​Q​​A​​P​​R​​Q​​G​​L​​L​​Y​​G​137  ​V​​P​​V​​S​​L​​K​​E​​C​​F​​S​147  ​Y​​K​​G​​H​​D​​S​​T​​L​​G​​L​157  ​S​​L​​N​​E​​G​​M​​P​​S​​E​​S​167  ​D​​C​​V​​V​​V​​Q​​V​​L​​K​​L​177  ​Q​​G​​A​​V​​P​​F​​V​​H​​T​​N​187  ​V​​P​​Q​​S​​M​​F​​S​​Y​​D​​C​197  ​S​​N​​P​​L​​F​​G​​Q​​T​​M​​N​207  ​P​​W​​K​​S​​S​​K​​S​​P​​G​​G​217  ​S​​S​​G​​G​​E​​G​​A​​L​​I​​G​227  ​S​​G​​G​​S​​P​​L​​G​​L​​G​​T​237  ​D​​I​​G​​G​​S​​I​​R​​F​​P​​S​247  ​A​​F​​C​​G​​I​​C​​G​​L​​K​​P​257  ​T​​G​​N​​R​​L​​S​​K​​S​​G​​L​267  ​K​​G​​C​​V​​Y​​G​​Q​​T​​A​​V​277  ​Q​​L​​S​​L​​G​​P​​M​​A​​R​​D​287  ​V​​E​​S​​L​​A​​L​​C​​L​​K​​A​297  ​L​​L​​C​​E​​H​​L​​F​​T​​L​​D​307  ​P​​T​​V​​P​​P​​L​​P​​F​​R​​E​317  ​E​​V​​Y​​R​​S​​S​​R​​P​​L​​R​327  ​V​​G​​Y​​Y​​E​​T​​D​​N​​Y​​T​337  ​M​​P​​S​​P​​A​​M​​R​​R​​A​​L​347  ​I​​E​​T​​K​​Q​​R​​L​​E​​A​​A​357  ​G​​H​​T​​L​​I​​P​​F​​L​​P​​N​367  ​N​​I​​P​​Y​​A​​L​​E​​V​​L​​S​377  ​T​​G​​G​​L​​F​​S​​D​​G​​G​​R​387  ​S​​F​​L​​Q​​N​​F​​K​​G​​D​​F​397  ​V​​D​​P​​C​​L​​G​​D​​L​​I​​L​407  ​I​​L​​R​​L​​P​​S​​W​​F​​K​​R​417  ​L​​L​​S​​L​​L​​L​​K​​P​​L​​F​427  ​P​​R​​L​​A​​A​​F​​L​​N​​N​​M​437  ​R​​P​​R​​S​​A​​E​​K​​L​​W​​K​447  ​L​​Q​​H​​E​​I​​E​​M​​Y​​R​​Q​457  ​S​​V​​I​​A​​Q​​W​​K​​A​​M​​N​467  ​L​​D​​V​​L​​L​​T​​P​​M​​L​​G​477  ​P​​A​​L​​D​​L​​N​​T​​P​​G​​R​487  ​A​​T​​G​​A​​V​​S​​Y​​T​​M​​L​497  ​Y​​N​​C​​L​​D​​F​​P​​A​​G​​V​507  ​V​​P​​V​​T​​T​​V​​T​​A​​E​​D​517  ​D​​A​​Q​​M​​E​​L​​Y​​K​​G​​Y​527  ​F​​G​​D​​I​​W​​D​​I​​I​​L​​K​537  ​K​​A​​M​​K​​N​​S​​V​​G​​L​​P​547  ​V​​A​​V​​Q​​C​​V​​A​​L​​P​​W​557  ​Q​​E​​E​​L​​C​​L​​R​​F​​M​​R​567  ​E​​V​​E​​Q​​L​​M​​T​​P​​Q​​K​577  ​Q​​P​​S​
Type
Asm Id
Dynamic Bonds

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