The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates

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RCSB PDB Mol* Viewer 2.10.6 [10/28/2024, 3:56:31 PM]
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Sequence of
     ​M​​G​​S​​S​​H​​H​​H​​H​​H​​H​     ​S​​S​​G​​R​​E​​N​​L​​Y​​F​​Q​     ​G​​H​​M​​N​​G​​D​​Q​​N​​S​​D​9    ​V​​Y​​A​​Q​​E​​K​​Q​​D​​F​​V​19   ​Q​​H​​F​​S​​Q​​I​​V​​R​​V​​L​29   ​T​​E​​D​​E​​M​​G​​H​​P​​E​​I​39   ​G​​D​​A​​I​​A​​R​​L​​K​​E​​V​49   ​L​​E​​Y​​N​​T​​I​​G​​G​​K​​Y​59   ​N​​R​​G​​L​​T​​V​​V​​V​​A​​F​69   ​R​​E​​L​​V​​E​​P​​R​​K​​Q​​D​79   ​A​​D​​S​​L​​Q​​R​​A​​W​​T​​V​89   ​G​​W​​C​​V​​E​​L​​L​​Q​​A​​F​99   ​F​​L​​V​​A​​D​​D​​I​​M​​D​​S​109  ​S​​L​​T​​R​​R​​G​​Q​​I​​C​​W​119  ​Y​​Q​​K​​P​​G​​V​​G​​L​​D​​A​129  ​I​​N​​D​​A​​N​​L​​L​​E​​A​​C​139  ​I​​Y​​R​​L​​L​​K​​L​​Y​​C​​R​149  ​E​​Q​​P​​Y​​Y​​L​​N​​L​​I​​E​159  ​L​​F​​L​​Q​​S​​S​​Y​​Q​​T​​E​169  ​I​​G​​Q​​T​​L​​D​​L​​L​​T​​A​179  ​P​​Q​​G​​N​​V​​D​​L​​V​​R​​F​189  ​T​​E​​K​​R​​Y​​K​​S​​I​​V​​K​199  ​Y​​K​​T​​A​​F​​Y​​S​​F​​Y​​L​209  ​P​​I​​A​​A​​A​​M​​Y​​M​​A​​G​219  ​I​​D​​G​​E​​K​​E​​H​​A​​N​​A​229  ​K​​K​​I​​L​​L​​E​​M​​G​​E​​F​239  ​A​​Q​​I​​Q​​D​​D​​Y​​L​​D​​L​249  ​F​​G​​D​​P​​S​​V​​T​​G​​K​​I​259  ​G​​T​​D​​I​​Q​​D​​N​​K​​C​​S​269  ​W​​L​​V​​V​​Q​​C​​L​​Q​​R​​A​279  ​T​​P​​E​​Q​​Y​​Q​​I​​L​​K​​E​289  ​N​​Y​​G​​Q​​K​​E​​A​​E​​K​​V​299  ​A​​R​​V​​K​​A​​L​​Y​​E​​E​​L​309  ​D​​L​​P​​A​​V​​F​​L​​Q​​Y​​E​319  ​E​​D​​S​​Y​​S​​H​​I​​M​​A​​L​329  ​I​​E​​Q​​Y​​A​​A​​P​​L​​P​​P​339  ​A​​V​​F​​L​​G​​L​​A​​R​​K​​I​349  ​Y​​K​​R​​R​​K​
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