6I3U | pdb_00006i3u

Optimization of potent and selective ATM inhibitors suitable for a proof-of-concept study in Huntington's disease models

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RCSB PDB Mol* Viewer 2.11.2 [1/27/2025, 4:56:27 PM]
Sequence of
     ​S​​M​​S​​K​​H​​H​​K​​L​​A​​R​276  ​S​​L​​R​​S​​G​​P​​S​​D​​H​​D​286  ​L​​K​​P​​N​​A​​A​​T​​R​​D​​Q​296  ​L​​N​​I​​I​​V​​S​​Y​​P​​P​​T​306  ​K​​Q​​L​​T​​Y​​E​​E​​Q​​D​​L​316  ​V​​W​​K​​F​​R​​Y​​Y​​L​​T​​N​326  ​Q​​E​​K​​A​​L​​T​​K​​F​​L​​K​336  ​C​​V​​N​​W​​D​​L​​P​​Q​​E​​A​346  ​K​​Q​​A​​L​​E​​L​​L​​G​​K​​W​356  ​K​​P​​M​​D​​V​​E​​D​​S​​L​​E​366  ​L​​L​​S​​S​​H​​Y​​T​​N​​P​​T​376  ​V​​R​​R​​Y​​A​​V​​A​​R​​L​​R​386  ​Q​​A​​D​​D​​E​​D​​L​​L​​M​​Y​396  ​L​​L​​Q​​L​​V​​Q​​A​​L​​K​​Y​406  ​E​​N​​F​​D​​D​​I​​K​​N​​G​​L​     ​E​​P​​T​​K​​K​​D​​S​​Q​​S​​S​     ​V​​S​​E​​N​​V​​S​​N​​S​​G​​I​     ​N​​S​​A​​E​​I​​D​​S​​S​​Q​​I​446  ​I​​T​​S​​P​​L​​P​​S​​V​​S​​S​     ​P​​P​​P​​A​​S​​K​​T​​K​​E​​V​     ​P​​D​​G​​E​​N​​L​​E​​Q​​D​​L​476  ​C​​T​​F​​L​​I​​S​​R​​A​​C​​K​486  ​N​​S​​T​​L​​A​​N​​Y​​L​​Y​​W​496  ​Y​​V​​I​​V​​E​​C​​E​​D​​Q​​D​506  ​T​​Q​​Q​​R​​D​​P​​K​​T​​H​​E​516  ​M​​Y​​L​​N​​V​​M​​R​​R​​F​​S​526  ​Q​​A​​L​​L​​K​​G​​D​​K​​S​​V​536  ​R​​V​​M​​R​​S​​L​​L​​A​​A​​Q​546  ​Q​​T​​F​​V​​D​​R​​L​​V​​H​​L​556  ​M​​K​​A​​V​​Q​​R​​E​​S​​G​​N​566  ​R​​K​​K​​K​​N​​E​​R​​L​​Q​​A​576  ​L​​L​​G​​D​​N​​E​​K​​M​​N​​L​586  ​S​​D​​V​​E​​L​​I​​P​​L​​P​​L​596  ​E​​P​​Q​​V​​K​​I​​R​​G​​I​​I​606  ​P​​E​​T​​A​​T​​L​​A​​K​​S​​A​616  ​N​​M​​P​​A​​Q​​L​​F​​F​​K​​T​626  ​E​​D​​G​​G​​K​​Y​​P​​V​​L​​F​636  ​K​​H​​G​​D​​D​​L​​R​​Q​​D​​Q​646  ​L​​I​​L​​Q​​I​​I​​S​​L​​M​​D​656  ​K​​L​​L​​R​​K​​E​​N​​L​​D​​L​666  ​K​​L​​T​​P​​Y​​K​​V​​L​​A​​T​676  ​S​​T​​K​​H​​G​​F​​L​​Q​​W​​I​686  ​Q​​G​​S​​V​​P​​V​​A​​E​​V​​L​696  ​D​​T​​E​​G​​S​​I​​Q​​N​​F​​F​706  ​R​​K​​Y​​A​​P​​S​​E​​N​​G​​P​716  ​N​​G​​I​​S​​A​​E​​V​​M​​D​​T​726  ​Y​​V​​K​​S​​C​​A​​G​​Y​​C​​V​736  ​I​​T​​Y​​I​​L​​G​​V​​G​​D​​R​746  ​H​​L​​D​​N​​L​​L​​L​​T​​K​​T​756  ​G​​K​​L​​F​​H​​I​​D​​F​​G​​Y​766  ​I​​L​​G​​R​​D​​P​​K​​P​​L​​P​776  ​P​​P​​M​​K​​L​​N​​K​​E​​M​​V​786  ​E​​G​​M​​G​​G​​T​​Q​​S​​E​​Q​796  ​Y​​Q​​E​​F​​R​​K​​Q​​C​​Y​​T​806  ​A​​F​​L​​H​​L​​R​​R​​Y​​S​​N​816  ​L​​I​​L​​N​​L​​F​​S​​L​​M​​V​826  ​D​​A​​N​​I​​P​​D​​I​​A​​L​​E​836  ​P​​D​​K​​T​​V​​K​​K​​V​​Q​​D​846  ​K​​F​​R​​L​​D​​L​​S​​D​​E​​E​856  ​A​​V​​H​​Y​​M​​Q​​S​​L​​I​​D​866  ​E​​S​​V​​H​​A​​L​​F​​A​​A​​V​     ​V​​E​​Q​​I​​H​
Type
Asm Id
Dynamic Bonds

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