1A4S

BETAINE ALDEHYDE DEHYDROGENASE FROM COD LIVER

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Structure Motif: Primary M-CSA Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1a4sa_	Alpha and beta proteins (a/b)	ALDH-like	ALDH-like	ALDH-like	Aldehyde reductase (dehydrogenase), ALDH	(Gadus morhua callarias ) [TaxId: 8053 ],	SCOPe (2.08)
B	d1a4sb_	Alpha and beta proteins (a/b)	ALDH-like	ALDH-like	ALDH-like	Aldehyde reductase (dehydrogenase), ALDH	(Gadus morhua callarias ) [TaxId: 8053 ],	SCOPe (2.08)
C	d1a4sc_	Alpha and beta proteins (a/b)	ALDH-like	ALDH-like	ALDH-like	Aldehyde reductase (dehydrogenase), ALDH	(Gadus morhua callarias ) [TaxId: 8053 ],	SCOPe (2.08)
D	d1a4sd_	Alpha and beta proteins (a/b)	ALDH-like	ALDH-like	ALDH-like	Aldehyde reductase (dehydrogenase), ALDH	(Gadus morhua callarias ) [TaxId: 8053 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	ALDH-like	8020648	4000806	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	ALDH-like	8033028	3001479	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	ALDH-like	8033028	3001479	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	ALDH-like	8033028	3001479	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	ALDH-like	8033028	3001479	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Aldedh_2nd	e1a4sA2	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_2nd	ECOD (1.6)
A	Aldedh_1st_1	e1a4sA1	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_1st_1	ECOD (1.6)
B	Aldedh_2nd	e1a4sB2	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_2nd	ECOD (1.6)
B	Aldedh_1st_1	e1a4sB1	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_1st_1	ECOD (1.6)
C	Aldedh_2nd	e1a4sC1	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_2nd	ECOD (1.6)
C	Aldedh_1st_1	e1a4sC2	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_1st_1	ECOD (1.6)
D	Aldedh_2nd	e1a4sD2	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_2nd	ECOD (1.6)
D	Aldedh_1st_1	e1a4sD1	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_1st_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.605.10	Alpha Beta	3-Layer(aba) Sandwich	Aldehyde Dehydrogenase	Chain A, domain 1	CATH (4.3.0)
A	3.40.309.10	Alpha Beta	3-Layer(aba) Sandwich	Aldehyde Dehydrogenase	Chain A, domain 2	CATH (4.3.0)
B	3.40.605.10	Alpha Beta	3-Layer(aba) Sandwich	Aldehyde Dehydrogenase	Chain A, domain 1	CATH (4.3.0)
B	3.40.309.10	Alpha Beta	3-Layer(aba) Sandwich	Aldehyde Dehydrogenase	Chain A, domain 2	CATH (4.3.0)
C	3.40.605.10	Alpha Beta	3-Layer(aba) Sandwich	Aldehyde Dehydrogenase	Chain A, domain 1	CATH (4.3.0)
C	3.40.309.10	Alpha Beta	3-Layer(aba) Sandwich	Aldehyde Dehydrogenase	Chain A, domain 2	CATH (4.3.0)
D	3.40.605.10	Alpha Beta	3-Layer(aba) Sandwich	Aldehyde Dehydrogenase	Chain A, domain 1	CATH (4.3.0)
D	3.40.309.10	Alpha Beta	3-Layer(aba) Sandwich	Aldehyde Dehydrogenase	Chain A, domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00171	Aldehyde dehydrogenase family (Aldedh)	Aldehyde dehydrogenase family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	BETAINE ALDEHYDE DEHYDROGENASE	oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors 4-trimethylammoniobutyraldehyde dehydrogenase activity catalytic activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor aldehyde dehydrogenase (NAD+) activity aminobutyraldehyde dehydrogenase (NAD+) activity aldehyde dehydrogenase [NAD(P)+] activity	carnitine metabolic process amino-acid betaine biosynthetic process biosynthetic process carnitine biosynthetic process modified amino acid biosynthetic process modified amino acid metabolic process metabolic process cellular process amino-acid betaine metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR015590	Aldehyde dehydrogenase domain	Domain
A, B, C, D	IPR016161	Aldehyde/histidinol dehydrogenase	Homologous Superfamily
A, B, C, D	IPR029510	Aldehyde dehydrogenase, glutamic acid active site	Conserved Site
A, B, C, D	IPR016162	Aldehyde dehydrogenase, N-terminal	Homologous Superfamily
A, B, C, D	IPR016163	Aldehyde dehydrogenase, C-terminal	Homologous Superfamily
A, B, C, D	IPR016160	Aldehyde dehydrogenase, cysteine active site	Conserved Site

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

Chains	Enzyme Name	Description	Catalytic Residues
A	betaine-aldehyde dehydrogenase M-CSA #100	Aldehyde dehydrogenases (ALDHs) catalyse the irreversible oxidation of a broad range of aldehydes to the corresponding acids. The substrates that ALDH work on include aliphatic and aromatic aldehydes, but also 2-enoic, 2-hydroxy, and 2-halogenated aldehydes. ALDHs are important components of cellular pathways that metabolise aldehydes and they have been ascribed important functions in cellular detoxification and defence systems.	Defined by 4 residues: ASN:A-166GLU:A-263CYS:A-297GLU:A-477 \| Explore in 3D: M-CSA Motif Definition Search M-CSA Motif EC: 1.2.1.8 (PDB Primary Data) Search M-CSA Motif + EC 1.2.1.8 EC: 1.2.1.47 (UniProt) Search M-CSA Motif + EC 1.2.1.47 EC: 1.2.1.3 (UniProt) Search M-CSA Motif + EC 1.2.1.3

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.