Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
BSCOP2B SuperfamilyHeme-dependent peroxidases 8038257 3000844 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyHeme-dependent peroxidases 8038257 3000844 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyHeme-dependent peroxidases 8038257 3000844 SCOP2B (2022-06-29)
ASCOP2 FamilyCCP-like 8025878 4001128 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyHeme-dependent peroxidases 8038257 3000844 SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
Bperoxidasee1apxB1 A: alpha complex topologyX: Heme-dependent peroxidases (From Topology)H: Heme-dependent peroxidases (From Topology)T: Heme-dependent peroxidasesF: peroxidaseECOD (1.6)
Cperoxidasee1apxC1 A: alpha complex topologyX: Heme-dependent peroxidases (From Topology)H: Heme-dependent peroxidases (From Topology)T: Heme-dependent peroxidasesF: peroxidaseECOD (1.6)
Dperoxidasee1apxD1 A: alpha complex topologyX: Heme-dependent peroxidases (From Topology)H: Heme-dependent peroxidases (From Topology)T: Heme-dependent peroxidasesF: peroxidaseECOD (1.6)
Aperoxidasee1apxA1 A: alpha complex topologyX: Heme-dependent peroxidases (From Topology)H: Heme-dependent peroxidases (From Topology)T: Heme-dependent peroxidasesF: peroxidaseECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
B1.10.520.10 Mainly Alpha Orthogonal Bundle Peroxidase domain 1CATH (4.3.0)
B1.10.420.10 Mainly Alpha Orthogonal Bundle Peroxidase domain 2CATH (4.3.0)
C1.10.520.10 Mainly Alpha Orthogonal Bundle Peroxidase domain 1CATH (4.3.0)
C1.10.420.10 Mainly Alpha Orthogonal Bundle Peroxidase domain 2CATH (4.3.0)
D1.10.520.10 Mainly Alpha Orthogonal Bundle Peroxidase domain 1CATH (4.3.0)
D1.10.420.10 Mainly Alpha Orthogonal Bundle Peroxidase domain 2CATH (4.3.0)
A1.10.520.10 Mainly Alpha Orthogonal Bundle Peroxidase domain 1CATH (4.3.0)
A1.10.420.10 Mainly Alpha Orthogonal Bundle Peroxidase domain 2CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D
PF00141Peroxidase (peroxidase)Peroxidase- Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

ChainsEnzyme NameDescriptionCatalytic Residues
L-ascorbate peroxidase  M-CSA #399

L-ascorbate peroxidase (AP) is a heme peroxidase. This group of enzyme catalyse the reduction of hydrogen peroxide (H2O2) to water and the concurrent oxidisation of a range of substrates, in this case ascorbic acid.

Ascorbic acid is a strong antioxidant that is effective in scavenging superoxide (O2-'), hydroxyl (OH') radicals and singlet oxygen. It can also remove H2O2 in the following reaction.

AP is the main enzyme responsible for hydrogen peroxide removal in the chloroplasts and cytosol of higher plants.

Defined by 5 residues: ARG:A-37 [auth A-38]HIS:A-41 [auth A-42]HIS:A-162 [auth A-163]TRP:A-178 [auth A-179]ASP:A-207 [auth A-208]
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