Annotations: 1BMF


Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Dd1bmfd1 All alpha proteins Left-handed superhelix C-terminal domain of alpha and beta (or A/B) subunits of rotary ATPases C-terminal domain of alpha and beta subunits of F1 ATP synthase F1 ATP synthase beta subunit, domain 3 (Bos taurus ) [TaxId: 9913 ], SCOPe (2.08)
Dd1bmfd2 All beta proteins Domain of alpha and beta subunits of F1 ATP synthase-like N-terminal domain of alpha and beta (or A/B) subunits of rotary ATPases N-terminal domain of alpha and beta subunits of F1 ATP synthase F1 ATP synthase beta subunit, domain 1 (Bos taurus ) [TaxId: 9913 ], SCOPe (2.08)
Dd1bmfd3 Alpha and beta proteins (a/b) P-loop containing nucleoside triphosphate hydrolases P-loop containing nucleoside triphosphate hydrolases RecA protein-like (ATPase-domain) Central domain of beta subunit of F1 ATP synthase (Bos taurus ) [TaxId: 9913 ], SCOPe (2.08)
Ed1bmfe1 All alpha proteins Left-handed superhelix C-terminal domain of alpha and beta (or A/B) subunits of rotary ATPases C-terminal domain of alpha and beta subunits of F1 ATP synthase F1 ATP synthase beta subunit, domain 3 (Bos taurus ) [TaxId: 9913 ], SCOPe (2.08)
Ed1bmfe2 All beta proteins Domain of alpha and beta subunits of F1 ATP synthase-like N-terminal domain of alpha and beta (or A/B) subunits of rotary ATPases N-terminal domain of alpha and beta subunits of F1 ATP synthase F1 ATP synthase beta subunit, domain 1 (Bos taurus ) [TaxId: 9913 ], SCOPe (2.08)
Ed1bmfe3 Alpha and beta proteins (a/b) P-loop containing nucleoside triphosphate hydrolases P-loop containing nucleoside triphosphate hydrolases RecA protein-like (ATPase-domain) Central domain of beta subunit of F1 ATP synthase (Bos taurus ) [TaxId: 9913 ], SCOPe (2.08)
Fd1bmff1 All alpha proteins Left-handed superhelix C-terminal domain of alpha and beta (or A/B) subunits of rotary ATPases C-terminal domain of alpha and beta subunits of F1 ATP synthase F1 ATP synthase beta subunit, domain 3 (Bos taurus ) [TaxId: 9913 ], SCOPe (2.08)
Fd1bmff2 All beta proteins Domain of alpha and beta subunits of F1 ATP synthase-like N-terminal domain of alpha and beta (or A/B) subunits of rotary ATPases N-terminal domain of alpha and beta subunits of F1 ATP synthase F1 ATP synthase beta subunit, domain 1 (Bos taurus ) [TaxId: 9913 ], SCOPe (2.08)
Fd1bmff3 Alpha and beta proteins (a/b) P-loop containing nucleoside triphosphate hydrolases P-loop containing nucleoside triphosphate hydrolases RecA protein-like (ATPase-domain) Central domain of beta subunit of F1 ATP synthase (Bos taurus ) [TaxId: 9913 ], SCOPe (2.08)
Ad1bmfa1 All alpha proteins Left-handed superhelix C-terminal domain of alpha and beta (or A/B) subunits of rotary ATPases C-terminal domain of alpha and beta subunits of F1 ATP synthase F1 ATP synthase alpha subunit, domain 3 (Bos taurus ) [TaxId: 9913 ], SCOPe (2.08)
Ad1bmfa2 All beta proteins Domain of alpha and beta subunits of F1 ATP synthase-like N-terminal domain of alpha and beta (or A/B) subunits of rotary ATPases N-terminal domain of alpha and beta subunits of F1 ATP synthase F1 ATP synthase alpha subunit, domain 1 (Bos taurus ) [TaxId: 9913 ], SCOPe (2.08)
Ad1bmfa3 Alpha and beta proteins (a/b) P-loop containing nucleoside triphosphate hydrolases P-loop containing nucleoside triphosphate hydrolases RecA protein-like (ATPase-domain) Central domain of alpha subunit of F1 ATP synthase (Bos taurus ) [TaxId: 9913 ], SCOPe (2.08)
Bd1bmfb1 All alpha proteins Left-handed superhelix C-terminal domain of alpha and beta (or A/B) subunits of rotary ATPases C-terminal domain of alpha and beta subunits of F1 ATP synthase F1 ATP synthase alpha subunit, domain 3 (Bos taurus ) [TaxId: 9913 ], SCOPe (2.08)
Bd1bmfb2 All beta proteins Domain of alpha and beta subunits of F1 ATP synthase-like N-terminal domain of alpha and beta (or A/B) subunits of rotary ATPases N-terminal domain of alpha and beta subunits of F1 ATP synthase F1 ATP synthase alpha subunit, domain 1 (Bos taurus ) [TaxId: 9913 ], SCOPe (2.08)
Bd1bmfb3 Alpha and beta proteins (a/b) P-loop containing nucleoside triphosphate hydrolases P-loop containing nucleoside triphosphate hydrolases RecA protein-like (ATPase-domain) Central domain of alpha subunit of F1 ATP synthase (Bos taurus ) [TaxId: 9913 ], SCOPe (2.08)
Cd1bmfc1 All alpha proteins Left-handed superhelix C-terminal domain of alpha and beta (or A/B) subunits of rotary ATPases C-terminal domain of alpha and beta subunits of F1 ATP synthase F1 ATP synthase alpha subunit, domain 3 (Bos taurus ) [TaxId: 9913 ], SCOPe (2.08)
Cd1bmfc2 All beta proteins Domain of alpha and beta subunits of F1 ATP synthase-like N-terminal domain of alpha and beta (or A/B) subunits of rotary ATPases N-terminal domain of alpha and beta subunits of F1 ATP synthase F1 ATP synthase alpha subunit, domain 1 (Bos taurus ) [TaxId: 9913 ], SCOPe (2.08)
Cd1bmfc3 Alpha and beta proteins (a/b) P-loop containing nucleoside triphosphate hydrolases P-loop containing nucleoside triphosphate hydrolases RecA protein-like (ATPase-domain) Central domain of alpha subunit of F1 ATP synthase (Bos taurus ) [TaxId: 9913 ], SCOPe (2.08)
Gd1bmfg_ Alpha and beta proteins (a/b) Pyruvate kinase C-terminal domain-like ATP synthase (F1-ATPase), gamma subunit ATP synthase (F1-ATPase), gamma subunit F1 ATP synthase gamma subunit (Bos taurus ) [TaxId: 9913 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
DSCOP2B SuperfamilyRecA-like P-loop NTPases 8018253 3002019 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyATP synthase alpha/beta C-terminal domain-like 8056904 3000684 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyATP synthase alpha/beta N-terminal domain-like 8018258 3001034 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyATP synthase alpha/beta N-terminal domain-like 8018258 3001034 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyRecA-like P-loop NTPases 8018253 3002019 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyATP synthase alpha/beta C-terminal domain-like 8056904 3000684 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyATP synthase alpha/beta N-terminal domain-like 8018258 3001034 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyATP synthase alpha/beta C-terminal domain-like 8056904 3000684 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyRecA-like P-loop NTPases 8018253 3002019 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyRecA-like P-loop NTPases 8018243 3002019 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyATP synthase alpha/beta C-terminal domain-like 8056868 3000684 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyATP synthase alpha/beta N-terminal domain-like 8018248 3001034 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyATP synthase alpha/beta N-terminal domain-like 8018248 3001034 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyRecA-like P-loop NTPases 8018243 3002019 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyATP synthase alpha/beta C-terminal domain-like 8056868 3000684 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyATP synthase alpha/beta N-terminal domain-like 8018248 3001034 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyRecA-like P-loop NTPases 8018243 3002019 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyATP synthase alpha/beta C-terminal domain-like 8056868 3000684 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
DATP-synt_ab_Ne1bmfD1 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: Alanine racemase-CF: ATP-synt_ab_NECOD (1.6)
DATP-synt_ab_Ce1bmfD3 A: alpha superhelicesX: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)H: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)T: C-terminal domain of alpha and beta subunits of F1 ATP synthaseF: ATP-synt_ab_CECOD (1.6)
DATP-synt_abe1bmfD2 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: ATP-synt_abECOD (1.6)
EATP-synt_ab_Ne1bmfE1 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: Alanine racemase-CF: ATP-synt_ab_NECOD (1.6)
EATP-synt_ab_Ce1bmfE3 A: alpha superhelicesX: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)H: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)T: C-terminal domain of alpha and beta subunits of F1 ATP synthaseF: ATP-synt_ab_CECOD (1.6)
EATP-synt_abe1bmfE2 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: ATP-synt_abECOD (1.6)
FATP-synt_ab_Ne1bmfF1 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: Alanine racemase-CF: ATP-synt_ab_NECOD (1.6)
FATP-synt_ab_Ce1bmfF3 A: alpha superhelicesX: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)H: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)T: C-terminal domain of alpha and beta subunits of F1 ATP synthaseF: ATP-synt_ab_CECOD (1.6)
FATP-synt_abe1bmfF2 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: ATP-synt_abECOD (1.6)
AATP-synt_ab_Ne1bmfA1 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: Alanine racemase-CF: ATP-synt_ab_NECOD (1.6)
AATP-synt_ab_Ce1bmfA2 A: alpha superhelicesX: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)H: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)T: C-terminal domain of alpha and beta subunits of F1 ATP synthaseF: ATP-synt_ab_CECOD (1.6)
AATP-synt_abe1bmfA3 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: ATP-synt_abECOD (1.6)
BATP-synt_ab_Ne1bmfB1 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: Alanine racemase-CF: ATP-synt_ab_NECOD (1.6)
BATP-synt_ab_Ce1bmfB2 A: alpha superhelicesX: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)H: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)T: C-terminal domain of alpha and beta subunits of F1 ATP synthaseF: ATP-synt_ab_CECOD (1.6)
BATP-synt_abe1bmfB3 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: ATP-synt_abECOD (1.6)
CATP-synt_ab_Ne1bmfC1 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: Alanine racemase-CF: ATP-synt_ab_NECOD (1.6)
CATP-synt_ab_Ce1bmfC2 A: alpha superhelicesX: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)H: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)T: C-terminal domain of alpha and beta subunits of F1 ATP synthaseF: ATP-synt_ab_CECOD (1.6)
CATP-synt_abe1bmfC3 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: ATP-synt_abECOD (1.6)
GATP-synte1bmfG1 A: a/b three-layered sandwichesX: ATP synthase (F1-ATPase), gamma subunit (From Topology)H: ATP synthase (F1-ATPase), gamma subunit (From Topology)T: ATP synthase (F1-ATPase), gamma subunitF: ATP-syntECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
D2.40.10.170 Mainly Beta Beta Barrel Thrombin, subunit H CATH (4.3.0)
D3.40.50.300 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold P-loop containing nucleotide triphosphate hydrolasesCATH (4.3.0)
D1.10.1140.10 Mainly Alpha Orthogonal Bundle Bovine Mitochondrial F1-ATPase, ATP Synthase Beta Chain Chain D, domain3CATH (4.3.0)
E2.40.10.170 Mainly Beta Beta Barrel Thrombin, subunit H CATH (4.3.0)
E3.40.50.300 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold P-loop containing nucleotide triphosphate hydrolasesCATH (4.3.0)
E1.10.1140.10 Mainly Alpha Orthogonal Bundle Bovine Mitochondrial F1-ATPase, ATP Synthase Beta Chain Chain D, domain3CATH (4.3.0)
F2.40.10.170 Mainly Beta Beta Barrel Thrombin, subunit H CATH (4.3.0)
F3.40.50.300 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold P-loop containing nucleotide triphosphate hydrolasesCATH (4.3.0)
F1.10.1140.10 Mainly Alpha Orthogonal Bundle Bovine Mitochondrial F1-ATPase, ATP Synthase Beta Chain Chain D, domain3CATH (4.3.0)
A2.40.30.20 Mainly Beta Beta Barrel Elongation Factor Tu (Ef-tu) domain 3CATH (4.3.0)
A3.40.50.300 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold P-loop containing nucleotide triphosphate hydrolasesCATH (4.3.0)
A1.20.150.20 Mainly Alpha Up-down Bundle Lysin ATP synthase alpha/beta chain, C-terminal domainCATH (4.3.0)
B2.40.30.20 Mainly Beta Beta Barrel Elongation Factor Tu (Ef-tu) domain 3CATH (4.3.0)
B3.40.50.300 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold P-loop containing nucleotide triphosphate hydrolasesCATH (4.3.0)
B1.20.150.20 Mainly Alpha Up-down Bundle Lysin ATP synthase alpha/beta chain, C-terminal domainCATH (4.3.0)
C2.40.30.20 Mainly Beta Beta Barrel Elongation Factor Tu (Ef-tu) domain 3CATH (4.3.0)
C3.40.50.300 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold P-loop containing nucleotide triphosphate hydrolasesCATH (4.3.0)
C1.20.150.20 Mainly Alpha Up-down Bundle Lysin ATP synthase alpha/beta chain, C-terminal domainCATH (4.3.0)
G1.10.287.80 Mainly Alpha Orthogonal Bundle Helix Hairpins ATP synthase, gamma subunit, helix hairpin domainCATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
D, E, F
PF00006ATP synthase alpha/beta family, nucleotide-binding domain (ATP-synt_ab)ATP synthase alpha/beta family, nucleotide-binding domainThis entry includes the ATP synthase alpha and beta subunits, the ATP synthase associated with flagella and the termination factor Rho.Domain
D, E, F
PF22919C-terminal domain of V and A type ATP synthase (ATP-synt_VA_C)C-terminal domain of V and A type ATP synthaseThis entry represents a small alpha helical domain found at the C-terminus of a variety of ATP synthases.Domain
D, E, F
PF02874ATP synthase alpha/beta family, beta-barrel domain (ATP-synt_ab_N)ATP synthase alpha/beta family, beta-barrel domainThis family includes the ATP synthase alpha and beta subunits the ATP synthase associated with flagella.Domain
A, B, C
PF00006ATP synthase alpha/beta family, nucleotide-binding domain (ATP-synt_ab)ATP synthase alpha/beta family, nucleotide-binding domainThis entry includes the ATP synthase alpha and beta subunits, the ATP synthase associated with flagella and the termination factor Rho.Domain
A, B, C
PF00306ATP synthase alpha/beta chain, C terminal domain (ATP-synt_ab_C)ATP synthase alpha/beta chain, C terminal domain- Domain
A, B, C
PF02874ATP synthase alpha/beta family, beta-barrel domain (ATP-synt_ab_N)ATP synthase alpha/beta family, beta-barrel domainThis family includes the ATP synthase alpha and beta subunits the ATP synthase associated with flagella.Domain
PF00231ATP synthase (ATP-synt)ATP synthase- Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
D, E, F
BOVINE MITOCHONDRIAL F1-ATPASE
A, B, C
BOVINE MITOCHONDRIAL F1-ATPASE
BOVINE MITOCHONDRIAL F1-ATPASE

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
D, E, F
IPR004100ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domainDomain
D, E, F
IPR024034ATPase, F1/V1 complex, beta/alpha subunit, C-terminalHomologous Superfamily
D, E, F
IPR036121ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamilyHomologous Superfamily
D, E, F
IPR020003ATPase, alpha/beta subunit, nucleotide-binding domain, active siteActive Site
D, E, F
IPR050053ATPase alpha/beta chainsFamily
D, E, F
IPR000194ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domainDomain
D, E, F
IPR055190ATP synthase A/B type, C-terminal domainDomain
D, E, F
IPR003593AAA+ ATPase domainDomain
D, E, F
IPR005722ATP synthase, F1 complex, beta subunitFamily
D, E, F
IPR027417P-loop containing nucleoside triphosphate hydrolaseHomologous Superfamily
A, B, C
IPR038376ATP synthase, alpha subunit, C-terminal domain superfamilyHomologous Superfamily
A, B, C
IPR004100ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domainDomain
A, B, C
IPR033732ATP synthase, F1 complex, alpha subunit nucleotide-binding domainDomain
A, B, C
IPR036121ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamilyHomologous Superfamily
A, B, C
IPR023366ATP synthase subunit alpha, N-terminal domain-like superfamilyHomologous Superfamily
A, B, C
IPR000793ATP synthase, alpha subunit, C-terminalDomain
A, B, C
IPR020003ATPase, alpha/beta subunit, nucleotide-binding domain, active siteActive Site
A, B, C
IPR000194ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domainDomain
A, B, C
IPR005294ATP synthase, F1 complex, alpha subunitFamily
A, B, C
IPR027417P-loop containing nucleoside triphosphate hydrolaseHomologous Superfamily
IPR023632ATP synthase, F1 complex, gamma subunit conserved siteConserved Site
IPR000131ATP synthase, F1 complex, gamma subunitFamily
IPR035968ATP synthase, F1 complex, gamma subunit superfamilyHomologous Superfamily

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

ChainsResource LinkGroupSubgroupProtein
A, B, C, D, E
mpstrucTRANSMEMBRANE PROTEINS: ALPHA-HELICALF-type ATPaseATP synthase (F1c10)

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

ChainsEnzyme NameDescriptionCatalytic Residues
C, D
H+-transporting two-sector ATPase (F-type, mitochondrial)  M-CSA #178

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1, containing the extramembraneous catalytic core, and F0, containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. Subunits alpha and beta form the catalytic core in F1.

F-type-ATPase utilises the proton motive force generated by photosynthesis and oxidative phosphorylation to synthesise ATP. It also catalyses the hydrolysis of ATP. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Rotation of the central stalk against the surrounding alpha3beta3 subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

Defined by 4 residues: ARG:C-373LYS:D-166 [auth D-162]GLU:D-192 [auth D-188]ARG:D-193 [auth D-189]
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