Annotations: 1ETH

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1etha1	All beta proteins	Lipase/lipooxygenase domain (PLAT/LH2 domain)	Lipase/lipooxygenase domain (PLAT/LH2 domain)	Colipase-binding domain	Pancreatic lipase, C-terminal domain	(Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)
A	d1etha2	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	Pancreatic lipase, N-terminal domain	Pancreatic lipase, N-terminal domain	(Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)
C	d1ethc1	All beta proteins	Lipase/lipooxygenase domain (PLAT/LH2 domain)	Lipase/lipooxygenase domain (PLAT/LH2 domain)	Colipase-binding domain	Pancreatic lipase, C-terminal domain	(Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)
C	d1ethc2	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	Pancreatic lipase, N-terminal domain	Pancreatic lipase, N-terminal domain	(Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)
B	d1ethb1	Small proteins	Knottins (small inhibitors, toxins, lectins)	Colipase-like	Colipase-like	(Pro)colipase	(Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)
D	d1ethd1	Small proteins	Knottins (small inhibitors, toxins, lectins)	Colipase-like	Colipase-like	(Pro)colipase	(Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Pancreatic lipase, N-terminal domain	8020253	4000743	SCOP2 (2022-06-29)
A	SCOP2 Family	Colipase-binding domain	8028699	4002394	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	alpha/beta-Hydrolases	8032633	3000102	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Lipase/lipooxygenase domain (PLAT/LH2 domain)	8041078	3001168	SCOP2 (2022-06-29)
C	SCOP2B Superfamily	alpha/beta-Hydrolases	8032633	3000102	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Lipase/lipooxygenase domain (PLAT/LH2 domain)	8041078	3001168	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Colipase-like	8038249	3000406	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Colipase-like	8038250	3000406	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Colipase-like	8038249	3000406	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Colipase-like	8038250	3000406	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PLAT	e1ethA1	A: beta sandwiches	X: jelly-roll	H: Lipase/lipooxygenase domain (PLAT/LH2 domain) (From Topology)	T: Lipase/lipooxygenase domain (PLAT/LH2 domain)	F: PLAT	ECOD (1.6)
A	Lipase	e1ethA2	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Lipase	ECOD (1.6)
C	PLAT	e1ethC1	A: beta sandwiches	X: jelly-roll	H: Lipase/lipooxygenase domain (PLAT/LH2 domain) (From Topology)	T: Lipase/lipooxygenase domain (PLAT/LH2 domain)	F: PLAT	ECOD (1.6)
C	Lipase	e1ethC2	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Lipase	ECOD (1.6)
B	Colipase	e1ethB1	A: few secondary structure elements	X: omega toxin-like	H: omega toxin-related	T: Colipase-like	F: Colipase	ECOD (1.6)
B	Colipase_C	e1ethB2	A: few secondary structure elements	X: omega toxin-like	H: omega toxin-related	T: Colipase-like	F: Colipase_C	ECOD (1.6)
D	Colipase	e1ethD1	A: few secondary structure elements	X: omega toxin-like	H: omega toxin-related	T: Colipase-like	F: Colipase	ECOD (1.6)
D	Colipase_C	e1ethD2	A: few secondary structure elements	X: omega toxin-like	H: omega toxin-related	T: Colipase-like	F: Colipase_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
A	2.60.60.20	Mainly Beta	Sandwich	Lipoxygenase-1	PLAT/LH2 domain	CATH (4.3.0)
C	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
C	2.60.60.20	Mainly Beta	Sandwich	Lipoxygenase-1	PLAT/LH2 domain	CATH (4.3.0)
B	2.10.80.10	Mainly Beta	Ribbon	Lipase, subunit A	Lipase, subunit A	CATH (4.3.0)
D	2.10.80.10	Mainly Beta	Ribbon	Lipase, subunit A	Lipase, subunit A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF00151	Lipase (Lipase)	Lipase		Domain
A, C	PF01477	PLAT/LH2 domain (PLAT)	PLAT/LH2 domain	This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain bind ...	This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase Pfam:PF01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.	Domain
B, D	PF02740	Colipase, C-terminal domain (Colipase_C)	Colipase, C-terminal domain	SCOP reports duplication of common fold with Colipase N-terminal domain.	Domain
B, D	PF01114	Colipase, N-terminal domain (Colipase)	Colipase, N-terminal domain	SCOP reports duplication of common fold with Colipase C-terminal domain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	TRIACYLGLYCEROL ACYL-HYDROLASE	all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity retinyl-palmitate esterase activity hydrolase activity, acting on ester bonds carboxylic ester hydrolase activity hydrolase activity catalytic activity triacylglycerol lipase activity lipase activity cation binding ion binding binding metal ion binding small molecule binding	lipid catabolic process catabolic process metabolic process cellular process primary metabolic process lipid metabolic process	cellular anatomical structure extracellular region extracellular space
B, D	COLIPASE	protein binding binding enzyme binding lipase binding enzyme regulator activity enzyme activator activity molecular function activator activity molecular function regulator activity catalytic activity	lipid catabolic process catabolic process metabolic process cellular process primary metabolic process lipid metabolic process biological process involved in interspecies interaction between organisms response to stimulus response to other organism response to bacterium response to external stimulus response to external biotic stimulus response to biotic stimulus response to nutrient levels lipid catabolic process catabolic process metabolic process cellular process primary metabolic process lipid metabolic process biological process involved in interspecies interaction between organisms response to stimulus response to other organism response to bacterium response to external stimulus response to external biotic stimulus response to biotic stimulus response to nutrient levels response to food response to chemical multicellular organismal process digestion	cellular anatomical structure extracellular region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR002331	Pancreatic lipase	Family
A, C	IPR033906	Lipase, N-terminal	Domain
A, C	IPR016272	Lipase, LIPH-type	Family
A, C	IPR000734	Triacylglycerol lipase family	Family
A, C	IPR036392	PLAT/LH2 domain superfamily	Homologous Superfamily
A, C	IPR029058	Alpha/Beta hydrolase fold	Homologous Superfamily
A, C	IPR001024	PLAT/LH2 domain	Domain
A, C	IPR013818	Lipase	Domain
B, D	IPR001981	Colipase	Family
B, D	IPR047576	Colipase, chordates	Family
B, D	IPR017913	Colipase, N-terminal	Domain
B, D	IPR017914	Colipase, C-terminal	Domain
B, D	IPR017915	Colipase, conserved site	Conserved Site

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
B, D	OPM	Monotopic/peripheral	Alpha/Beta monotopic/peripheral	Alpha/beta-hydrolases	Pancreatic lipase-related

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.