Annotations: 1EZR

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C	d1ezrc_	Alpha and beta proteins (a/b)	Nucleoside hydrolase	Nucleoside hydrolase	Nucleoside hydrolase	Nucleoside hydrolase	(Leishmania major ) [TaxId: 5664 ],	SCOPe (2.08)
A	d1ezra_	Alpha and beta proteins (a/b)	Nucleoside hydrolase	Nucleoside hydrolase	Nucleoside hydrolase	Nucleoside hydrolase	(Leishmania major ) [TaxId: 5664 ],	SCOPe (2.08)
B	d1ezrb_	Alpha and beta proteins (a/b)	Nucleoside hydrolase	Nucleoside hydrolase	Nucleoside hydrolase	Nucleoside hydrolase	(Leishmania major ) [TaxId: 5664 ],	SCOPe (2.08)
D	d1ezrd_	Alpha and beta proteins (a/b)	Nucleoside hydrolase	Nucleoside hydrolase	Nucleoside hydrolase	Nucleoside hydrolase	(Leishmania major ) [TaxId: 5664 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C	SCOP2B Superfamily	Nucleoside hydrolase	8032663	3001240	SCOP2B (2022-06-29)
A	SCOP2 Family	Nucleoside hydrolase	8020283	4000751	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Nucleoside hydrolase	8032663	3001240	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Nucleoside hydrolase	8032663	3001240	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Nucleoside hydrolase	8032663	3001240	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C	IU_nuc_hydro	e1ezrC1	A: a/b three-layered sandwiches	X: Nucleoside hydrolase (From Topology)	H: Nucleoside hydrolase (From Topology)	T: Nucleoside hydrolase	F: IU_nuc_hydro	ECOD (1.6)
A	IU_nuc_hydro	e1ezrA1	A: a/b three-layered sandwiches	X: Nucleoside hydrolase (From Topology)	H: Nucleoside hydrolase (From Topology)	T: Nucleoside hydrolase	F: IU_nuc_hydro	ECOD (1.6)
B	IU_nuc_hydro	e1ezrB1	A: a/b three-layered sandwiches	X: Nucleoside hydrolase (From Topology)	H: Nucleoside hydrolase (From Topology)	T: Nucleoside hydrolase	F: IU_nuc_hydro	ECOD (1.6)
D	IU_nuc_hydro	e1ezrD1	A: a/b three-layered sandwiches	X: Nucleoside hydrolase (From Topology)	H: Nucleoside hydrolase (From Topology)	T: Nucleoside hydrolase	F: IU_nuc_hydro	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C	3.90.245.10	Alpha Beta	Alpha-Beta Complex	Inosine-uridine Nucleoside N-ribohydrolase	Chain A	CATH (4.3.0)
A	3.90.245.10	Alpha Beta	Alpha-Beta Complex	Inosine-uridine Nucleoside N-ribohydrolase	Chain A	CATH (4.3.0)
B	3.90.245.10	Alpha Beta	Alpha-Beta Complex	Inosine-uridine Nucleoside N-ribohydrolase	Chain A	CATH (4.3.0)
D	3.90.245.10	Alpha Beta	Alpha-Beta Complex	Inosine-uridine Nucleoside N-ribohydrolase	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF01156	Inosine-uridine preferring nucleoside hydrolase (IU_nuc_hydro)	Inosine-uridine preferring nucleoside hydrolase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	NUCLEOSIDE HYDROLASE	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding hydrolase activity, acting on glycosyl bonds purine nucleosidase activity hydrolase activity hydrolase activity, hydrolyzing N-glycosyl compounds catalytic activity inosine nucleosidase activity uridine nucleosidase activity ribosylpyrimidine nucleosidase activity	nucleoside phosphate metabolic process primary metabolic process nucleotide metabolic process nucleobase-containing compound metabolic process organophosphate metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process metabolic process cellular process small molecule metabolic process phosphorus metabolic process purine-containing compound salvage biosynthetic process purine-containing compound biosynthetic process nucleoside phosphate metabolic process primary metabolic process nucleotide metabolic process nucleobase-containing compound metabolic process organophosphate metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process metabolic process cellular process small molecule metabolic process phosphorus metabolic process purine-containing compound salvage biosynthetic process purine-containing compound biosynthetic process cellular metabolic compound salvage purine-containing compound metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR036452	Ribonucleoside hydrolase-like	Homologous Superfamily
A, B, C, D	IPR015910	Inosine/uridine-preferring nucleoside hydrolase, conserved site	Conserved Site
A, B, C, D	IPR023186	Inosine/uridine-preferring nucleoside hydrolase	Family
A, B, C, D	IPR001910	Inosine/uridine-preferring nucleoside hydrolase domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.