1FD4

HUMAN BETA-DEFENSIN 2

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d1fd4b_	Small proteins	Defensin-like	Defensin-like	Defensin	Beta-defensin, BD	( ) [TaxId: ], (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d1fd4c_	Small proteins	Defensin-like	Defensin-like	Defensin	Beta-defensin, BD	( ) [TaxId: ], (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d1fd4d_	Small proteins	Defensin-like	Defensin-like	Defensin	Beta-defensin, BD	( ) [TaxId: ], (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d1fd4e_	Small proteins	Defensin-like	Defensin-like	Defensin	Beta-defensin, BD	( ) [TaxId: ], (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F	d1fd4f_	Small proteins	Defensin-like	Defensin-like	Defensin	Beta-defensin, BD	( ) [TaxId: ], (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
G	d1fd4g_	Small proteins	Defensin-like	Defensin-like	Defensin	Beta-defensin, BD	( ) [TaxId: ], (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
H	d1fd4h_	Small proteins	Defensin-like	Defensin-like	Defensin	Beta-defensin, BD	( ) [TaxId: ], (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
I	d1fd4i_	Small proteins	Defensin-like	Defensin-like	Defensin	Beta-defensin, BD	( ) [TaxId: ], (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
J	d1fd4j_	Small proteins	Defensin-like	Defensin-like	Defensin	Beta-defensin, BD	( ) [TaxId: ], (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
K	d1fd4k_	Small proteins	Defensin-like	Defensin-like	Defensin	Beta-defensin, BD	( ) [TaxId: ], (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
L	d1fd4l_	Small proteins	Defensin-like	Defensin-like	Defensin	Beta-defensin, BD	( ) [TaxId: ], (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
M	d1fd4m_	Small proteins	Defensin-like	Defensin-like	Defensin	Beta-defensin, BD	( ) [TaxId: ], (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
N	d1fd4n_	Small proteins	Defensin-like	Defensin-like	Defensin	Beta-defensin, BD	( ) [TaxId: ], (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
P	d1fd4p_	Small proteins	Defensin-like	Defensin-like	Defensin	Beta-defensin, BD	( ) [TaxId: ], (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1fd4a_	Small proteins	Defensin-like	Defensin-like	Defensin	Beta-defensin, BD	( ) [TaxId: ], (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
O	d1fd4o_	Small proteins	Defensin-like	Defensin-like	Defensin	Beta-defensin, BD	( ) [TaxId: ], (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Defensin-like	8038596	3000681	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Defensin-like	8038596	3000681	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Defensin-like	8038596	3000681	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Defensin-like	8038596	3000681	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Defensin-like	8038596	3000681	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Defensin-like	8038596	3000681	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Defensin-like	8038596	3000681	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Defensin-like	8038596	3000681	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Defensin-like	8038596	3000681	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	Defensin-like	8038596	3000681	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	Defensin-like	8038596	3000681	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	Defensin-like	8038596	3000681	SCOP2B (2022-06-29)
N	SCOP2B Superfamily	Defensin-like	8038596	3000681	SCOP2B (2022-06-29)
P	SCOP2B Superfamily	Defensin-like	8038596	3000681	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Defensin-like	8038596	3000681	SCOP2B (2022-06-29)
O	SCOP2B Superfamily	Defensin-like	8038596	3000681	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Defensin_beta	e1fd4B1	A: few secondary structure elements	X: Defensin-like	H: Defensin-related	T: Defensin-related	F: Defensin_beta	ECOD (1.6)
C	Defensin_beta	e1fd4C1	A: few secondary structure elements	X: Defensin-like	H: Defensin-related	T: Defensin-related	F: Defensin_beta	ECOD (1.6)
D	Defensin_beta	e1fd4D1	A: few secondary structure elements	X: Defensin-like	H: Defensin-related	T: Defensin-related	F: Defensin_beta	ECOD (1.6)
E	Defensin_beta	e1fd4E1	A: few secondary structure elements	X: Defensin-like	H: Defensin-related	T: Defensin-related	F: Defensin_beta	ECOD (1.6)
F	Defensin_beta	e1fd4F1	A: few secondary structure elements	X: Defensin-like	H: Defensin-related	T: Defensin-related	F: Defensin_beta	ECOD (1.6)
G	Defensin_beta	e1fd4G1	A: few secondary structure elements	X: Defensin-like	H: Defensin-related	T: Defensin-related	F: Defensin_beta	ECOD (1.6)
H	Defensin_beta	e1fd4H1	A: few secondary structure elements	X: Defensin-like	H: Defensin-related	T: Defensin-related	F: Defensin_beta	ECOD (1.6)
I	Defensin_beta	e1fd4I1	A: few secondary structure elements	X: Defensin-like	H: Defensin-related	T: Defensin-related	F: Defensin_beta	ECOD (1.6)
J	Defensin_beta	e1fd4J1	A: few secondary structure elements	X: Defensin-like	H: Defensin-related	T: Defensin-related	F: Defensin_beta	ECOD (1.6)
K	Defensin_beta	e1fd4K1	A: few secondary structure elements	X: Defensin-like	H: Defensin-related	T: Defensin-related	F: Defensin_beta	ECOD (1.6)
L	Defensin_beta	e1fd4L1	A: few secondary structure elements	X: Defensin-like	H: Defensin-related	T: Defensin-related	F: Defensin_beta	ECOD (1.6)
M	Defensin_beta	e1fd4M1	A: few secondary structure elements	X: Defensin-like	H: Defensin-related	T: Defensin-related	F: Defensin_beta	ECOD (1.6)
N	Defensin_beta	e1fd4N1	A: few secondary structure elements	X: Defensin-like	H: Defensin-related	T: Defensin-related	F: Defensin_beta	ECOD (1.6)
P	Defensin_beta	e1fd4P1	A: few secondary structure elements	X: Defensin-like	H: Defensin-related	T: Defensin-related	F: Defensin_beta	ECOD (1.6)
A	Defensin_beta	e1fd4A1	A: few secondary structure elements	X: Defensin-like	H: Defensin-related	T: Defensin-related	F: Defensin_beta	ECOD (1.6)
O	Defensin_beta	e1fd4O1	A: few secondary structure elements	X: Defensin-like	H: Defensin-related	T: Defensin-related	F: Defensin_beta	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.10.360.10	Alpha Beta	Roll	Antimicrobial Peptide, Beta-defensin 2	Chain A	CATH (4.3.0)
C	3.10.360.10	Alpha Beta	Roll	Antimicrobial Peptide, Beta-defensin 2	Chain A	CATH (4.3.0)
D	3.10.360.10	Alpha Beta	Roll	Antimicrobial Peptide, Beta-defensin 2	Chain A	CATH (4.3.0)
E	3.10.360.10	Alpha Beta	Roll	Antimicrobial Peptide, Beta-defensin 2	Chain A	CATH (4.3.0)
F	3.10.360.10	Alpha Beta	Roll	Antimicrobial Peptide, Beta-defensin 2	Chain A	CATH (4.3.0)
G	3.10.360.10	Alpha Beta	Roll	Antimicrobial Peptide, Beta-defensin 2	Chain A	CATH (4.3.0)
H	3.10.360.10	Alpha Beta	Roll	Antimicrobial Peptide, Beta-defensin 2	Chain A	CATH (4.3.0)
I	3.10.360.10	Alpha Beta	Roll	Antimicrobial Peptide, Beta-defensin 2	Chain A	CATH (4.3.0)
J	3.10.360.10	Alpha Beta	Roll	Antimicrobial Peptide, Beta-defensin 2	Chain A	CATH (4.3.0)
K	3.10.360.10	Alpha Beta	Roll	Antimicrobial Peptide, Beta-defensin 2	Chain A	CATH (4.3.0)
L	3.10.360.10	Alpha Beta	Roll	Antimicrobial Peptide, Beta-defensin 2	Chain A	CATH (4.3.0)
M	3.10.360.10	Alpha Beta	Roll	Antimicrobial Peptide, Beta-defensin 2	Chain A	CATH (4.3.0)
N	3.10.360.10	Alpha Beta	Roll	Antimicrobial Peptide, Beta-defensin 2	Chain A	CATH (4.3.0)
P	3.10.360.10	Alpha Beta	Roll	Antimicrobial Peptide, Beta-defensin 2	Chain A	CATH (4.3.0)
A	3.10.360.10	Alpha Beta	Roll	Antimicrobial Peptide, Beta-defensin 2	Chain A	CATH (4.3.0)
O	3.10.360.10	Alpha Beta	Roll	Antimicrobial Peptide, Beta-defensin 2	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P	PF00711	Beta defensin (Defensin_beta)	Beta defensin	The beta defensins are antimicrobial peptides implicated in the resistance of epithelial surfaces to microbial colonisation [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P	BETA-DEFENSIN 2	binding ion binding phosphatidylinositol-4,5-bisphosphate binding anion binding phosphatidylinositol bisphosphate binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding small molecule binding protein binding molecular function activator activity signaling receptor binding molecular function regulator activity binding ion binding phosphatidylinositol-4,5-bisphosphate binding anion binding phosphatidylinositol bisphosphate binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding small molecule binding protein binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity receptor ligand activity chemoattractant activity signaling receptor activator activity CCR chemokine receptor binding cytokine receptor binding G protein-coupled receptor binding chemokine receptor binding CCR6 chemokine receptor binding	chemotaxis response to stimulus taxis response to chemical response to external stimulus locomotion biological process involved in interspecies interaction between organisms antifungal innate immune response immune response response to other organism defense response defense response to symbiont response to biotic stimulus defense response to fungus chemotaxis response to stimulus taxis response to chemical response to external stimulus locomotion biological process involved in interspecies interaction between organisms antifungal innate immune response immune response response to other organism defense response defense response to symbiont response to biotic stimulus defense response to fungus immune system process defense response to other organism response to stress innate immune response response to external biotic stimulus response to fungus cell chemotaxis cellular response to stimulus cellular response to chemical stimulus cell migration cellular process cell motility humoral immune response antimicrobial humoral response antimicrobial humoral immune response mediated by antimicrobial peptide disruption of cell in another organism disruption of anatomical structure in another organism killing of cells of another organism cell killing defense response to Gram-negative bacterium defense response to bacterium response to bacterium regulation of biological process regulation of cellular process signaling biological regulation G protein-coupled receptor signaling pathway signal transduction cell communication defense response to Gram-positive bacterium	membrane-bounded organelle intracellular anatomical structure Golgi apparatus membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen Golgi lumen intracellular organelle cellular anatomical structure organelle lumen organelle cytoplasm extracellular region membrane-bounded organelle intracellular anatomical structure Golgi apparatus membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen Golgi lumen intracellular organelle cellular anatomical structure organelle lumen organelle cytoplasm extracellular region extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P	IPR001855	Beta-defensin-like domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P	IPR006080	Beta/alpha-defensin, C-terminal	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P	Pharos: O15263	psoriasis streptococcal pneumonia

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.