1FEX | pdb_00001fex

SOLUTION STRUCTURE OF MYB-DOMAIN OF HUMAN RAP1

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1fexa_	All alpha proteins	DNA/RNA-binding 3-helical bundle	Homeodomain-like	Myb/SANT domain	Rap1	( ) [TaxId: ], (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Myb/SANT domain	8002307	4000317	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Homeodomain-like	8057566	3000001	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Myb_DNA-bind_2	e1fexA1	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: Myb_DNA-bind_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.10.60	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Homeodomain-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF08914	Rap1 Myb domain (Myb_Rap1)	Rap1 Myb domain	This entry represents the Myb domain found in telomeric repeat-binding factor 2-interacting protein 1 (TERF2IP) from animals and DNA-binding proteins RAP1 from yeast. These proteins are involved in the regulation of telomere length, clustering and ha ...	This entry represents the Myb domain found in telomeric repeat-binding factor 2-interacting protein 1 (TERF2IP) from animals and DNA-binding proteins RAP1 from yeast. These proteins are involved in the regulation of telomere length, clustering and have a specific role in telomere position effect (TPE) [1,2]. This domain binds DNA in Saccharomyces cerevisiae [3], but not in animals and Schizosaccharomyces pombe where it may either interact with DNA via an adaptor protein or it may be only involved in protein-protein interactions [4,5].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	TRF2-INTERACTING TELOMERIC RAP1 PROTEIN	sequence-specific DNA binding DNA binding binding nucleic acid binding telomeric DNA binding G-rich strand telomeric DNA binding sequence-specific single stranded DNA binding single-stranded telomeric DNA binding single-stranded DNA binding phosphatase binding protein binding enzyme binding	cellular response to stimulus regulation of DNA recombination regulation of cellular process regulation of double-strand break repair response to stimulus regulation of cellular response to stress regulation of primary metabolic process nucleobase-containing compound metabolic process cellular response to stress response to stress regulation of response to stress recombinational repair regulation of nucleobase-containing compound metabolic process double-strand break repair via homologous recombination cellular response to stimulus regulation of DNA recombination regulation of cellular process regulation of double-strand break repair response to stimulus regulation of cellular response to stress regulation of primary metabolic process nucleobase-containing compound metabolic process cellular response to stress response to stress regulation of response to stress recombinational repair regulation of nucleobase-containing compound metabolic process double-strand break repair via homologous recombination DNA repair double-strand break repair regulation of biological process DNA recombination biological regulation primary metabolic process DNA metabolic process regulation of macromolecule metabolic process nucleic acid metabolic process regulation of DNA repair regulation of double-strand break repair via homologous recombination DNA damage response regulation of response to stimulus metabolic process cellular process macromolecule metabolic process regulation of metabolic process regulation of DNA metabolic process positive regulation of cell communication positive regulation of signal transduction positive regulation of canonical NF-kappaB signal transduction signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette signal transduction positive regulation of cellular process regulation of signaling positive regulation of intracellular signal transduction canonical NF-kappaB signal transduction regulation of cell communication regulation of canonical NF-kappaB signal transduction positive regulation of signaling telomere maintenance via telomerase telomere organization chromosome organization nucleobase-containing compound biosynthetic process macromolecule biosynthetic process RNA-templated DNA biosynthetic process telomere maintenance via telomere lengthening telomere maintenance cellular component organization nucleic acid biosynthetic process organelle organization biosynthetic process cellular component organization or biogenesis DNA biosynthetic process negative regulation of biological process regulation of DNA recombination at telomere negative regulation of DNA recombination at telomere negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of DNA recombination negative regulation of DNA metabolic process regulation of protein modification process regulation of protein phosphorylation negative regulation of phosphate metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of protein modification process protein metabolic process protein modification process phosphorus metabolic process negative regulation of protein metabolic process protein phosphorylation phosphorylation regulation of protein metabolic process negative regulation of protein phosphorylation macromolecule modification negative regulation of phosphorus metabolic process regulation of phosphorylation regulation of phosphorus metabolic process negative regulation of phosphorylation regulation of telomere maintenance regulation of cellular component organization regulation of chromosome organization regulation of organelle organization positive regulation of DNA-binding transcription factor activity positive regulation of NF-kappaB transcription factor activity RNA metabolic process RNA biosynthetic process positive regulation of molecular function DNA-templated transcription regulation of RNA metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process gene expression regulation of molecular function regulation of gene expression regulation of DNA-binding transcription factor activity regulation of macromolecule biosynthetic process regulation of DNA-templated transcription negative regulation of telomere maintenance negative regulation of chromosome organization negative regulation of cellular component organization negative regulation of organelle organization regulation of non-canonical NF-kappaB signal transduction non-canonical NF-kappaB signal transduction positive regulation of non-canonical NF-kappaB signal transduction protein localization localization cellular localization protein localization to chromosome protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to chromosome, telomeric region positive regulation of organelle organization positive regulation of cellular component organization positive regulation of metabolic process positive regulation of macromolecule metabolic process positive regulation of telomere maintenance positive regulation of nucleobase-containing compound metabolic process positive regulation of chromosome organization positive regulation of DNA metabolic process telomere maintenance in response to DNA damage protection from non-homologous end joining at telomere telomere capping	membrane-bounded organelle protein-containing complex intracellular anatomical structure protein-DNA complex nucleus intracellular membraneless organelle nuclear protein-containing complex chromosome intracellular membrane-bounded organelle chromosomal region intracellular organelle cellular anatomical structure organelle telomere cap complex membrane-bounded organelle protein-containing complex intracellular anatomical structure protein-DNA complex nucleus intracellular membraneless organelle nuclear protein-containing complex chromosome intracellular membrane-bounded organelle chromosomal region intracellular organelle cellular anatomical structure organelle telomere cap complex membraneless organelle chromosome, telomeric repeat region chromosome, telomeric region shelterin complex nuclear telomere cap complex cytoplasm membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen nuclear chromosome male germ cell nucleus germ cell nucleus nuclear body

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR038104	TRF2-interacting telomeric protein/Rap1, C-terminal domain superfamily	Homologous Superfamily
A	IPR001357	BRCT domain	Domain
A	IPR036420	BRCT domain superfamily	Homologous Superfamily
A	IPR009057	Homedomain-like superfamily	Homologous Superfamily
A	IPR039595	TE2IP/Rap1	Family
A	IPR021661	TRF2-interacting telomeric protein/Rap1, C-terminal	Domain
A	IPR015010	TERF2-interacting telomeric protein 1, Myb domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9NYB0	attention deficit hyperactivity disorder, inattentive type glioblastoma Pick disease dermatomyositis lung carcinoma subependymal giant cell astrocytoma familial melanoma ovarian cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.