1FJK | pdb_00001fjk

NMR Solution Structure of Phospholamban (C41F)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1fjka_	Peptides	Phospholamban fragments	Phospholamban fragments	Phospholamban fragments	Phospholamban fragments	(Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.5.290	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Phospholamban	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF04272	Phospholamban (Phospholamban)	Phospholamban	The regulation of calcium levels across the membrane of the sarcoplasmic reticulum involves the interplay of many membrane proteins. Phospholamban is a 52 residue integral membrane protein that is involved in reversibly inhibiting the Ca(2+) pump and ...	The regulation of calcium levels across the membrane of the sarcoplasmic reticulum involves the interplay of many membrane proteins. Phospholamban is a 52 residue integral membrane protein that is involved in reversibly inhibiting the Ca(2+) pump and regulating the flow of Ca ions across the sarcoplasmic reticulum membrane during muscle contraction and relaxation [1]. Phospholamban is thought to form a pentamer in the membrane [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	CARDIAC PHOSPHOLAMBAN	molecular function inhibitor activity molecular function regulator activity ATPase inhibitor activity ATPase regulator activity ATP-dependent activity identical protein binding protein binding binding protein homodimerization activity protein dimerization activity	heart process multicellular organismal process system process regulation of actin filament-based process regulation of cellular process regulation of heart contraction regulation of system process cardiac muscle contraction striated muscle contraction circulatory system process actin filament-based process regulation of multicellular organismal process blood circulation cardiac muscle cell contraction heart process multicellular organismal process system process regulation of actin filament-based process regulation of cellular process regulation of heart contraction regulation of system process cardiac muscle contraction striated muscle contraction circulatory system process actin filament-based process regulation of multicellular organismal process blood circulation cardiac muscle cell contraction regulation of biological process biological regulation regulation of cardiac muscle contraction actin filament-based movement muscle contraction muscle system process regulation of muscle system process regulation of blood circulation regulation of striated muscle contraction regulation of actin filament-based movement regulation of muscle contraction regulation of cardiac muscle cell contraction cellular process actin-mediated cell contraction heart contraction regulation of calcium ion import regulation of calcium ion transport regulation of localization transport regulation of transport regulation of monoatomic ion transport establishment of localization calcium ion transport metal ion transport localization monoatomic ion transport calcium ion import monoatomic cation transport regulation of metal ion transport cellular response to stimulus adenylate cyclase-activating adrenergic receptor signaling pathway adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process response to stimulus signaling adenylate cyclase-activating G protein-coupled receptor signaling pathway cell communication adrenergic receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway signal transduction G protein-coupled receptor signaling pathway involved in heart process inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process calcium ion homeostasis cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis response to light stimulus learning learning or memory nervous system process visual learning visual behavior cognition associative learning behavior response to radiation response to abiotic stimulus regulation of relaxation of muscle relaxation of muscle regulation of the force of heart contraction by cardiac conduction cardiac conduction regulation of biological quality regulation of the force of heart contraction circadian sleep/wake cycle, sleep rhythmic process circadian sleep/wake cycle circadian behavior rhythmic behavior circadian rhythm sleep circadian sleep/wake cycle process negative regulation of biological process sarcoplasmic reticulum calcium ion transport release of sequestered calcium ion into cytosol by sarcoplasmic reticulum intracellular signal transduction intracellular signaling cassette release of sequestered calcium ion into cytosol by endoplasmic reticulum regulation of release of sequestered calcium ion into cytosol inorganic ion transmembrane transport inorganic cation transmembrane transport maintenance of location transmembrane transport release of sequestered calcium ion into cytosol regulation of transmembrane transport calcium-mediated signaling cellular localization monoatomic ion transmembrane transport regulation of monoatomic ion transmembrane transport negative regulation of sequestering of calcium ion regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion maintenance of location in cell regulation of calcium ion transmembrane transport monoatomic cation transmembrane transport negative regulation of cellular process regulation of sequestering of calcium ion calcium ion transmembrane import into cytosol regulation of cardiac muscle contraction by calcium ion signaling sequestering of calcium ion regulation of monoatomic cation transmembrane transport calcium ion transmembrane transport regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum locomotory behavior locomotor rhythm developmental process heart development cardiac muscle tissue development animal organ development tissue development striated muscle tissue development circulatory system development multicellular organism development anatomical structure development muscle tissue development system development negative regulation of calcium ion import into sarcoplasmic reticulum negative regulation of monoatomic ion transport negative regulation of transport establishment of localization in cell regulation of intracellular transport negative regulation of intracellular transport intracellular transport negative regulation of calcium ion transport regulation of cellular localization regulation of calcium ion import into sarcoplasmic reticulum calcium ion import into sarcoplasmic reticulum negative regulation of heart rate negative regulation of blood circulation negative regulation of heart contraction negative regulation of multicellular organismal process regulation of heart rate spermatid development spermatid differentiation sexual reproduction cellular developmental process spermatogenesis cellular component assembly involved in morphogenesis reproductive process cell development cellular process involved in reproduction in multicellular organism developmental process involved in reproduction gamete generation cellular component organization cellular component biogenesis vesicle organization cellular anatomical entity morphogenesis cellular component assembly cell differentiation cellular component organization or biogenesis endomembrane system organization organelle assembly secretory granule organization multicellular organismal reproductive process male gamete generation anatomical structure morphogenesis organelle organization anatomical structure formation involved in morphogenesis germ cell development acrosome assembly regulation of calcium ion transmembrane transporter activity negative regulation of ATP-dependent activity regulation of ATP-dependent activity negative regulation of ion transmembrane transporter activity negative regulation of calcium ion transmembrane transporter activity negative regulation of cation transmembrane transport regulation of molecular function negative regulation of calcium ion transmembrane transport regulation of transmembrane transporter activity negative regulation of transmembrane transport regulation of transporter activity negative regulation of monoatomic ion transmembrane transport regulation of monoatomic ion transmembrane transporter activity negative regulation of transporter activity negative regulation of molecular function regulation of ATPase-coupled calcium transmembrane transporter activity negative regulation of ATPase-coupled calcium transmembrane transporter activity cell surface receptor signaling pathway Notch signaling pathway muscle cell cellular homeostasis	cellular anatomical structure membrane ATPase dependent transmembrane transport complex cation-transporting ATPase complex protein-containing complex transmembrane transporter complex membrane protein complex transporter complex calcium ion-transporting ATPase complex membrane-bounded organelle intracellular anatomical structure organelle subcompartment intracellular membrane-bounded organelle endomembrane system cellular anatomical structure membrane ATPase dependent transmembrane transport complex cation-transporting ATPase complex protein-containing complex transmembrane transporter complex membrane protein complex transporter complex calcium ion-transporting ATPase complex membrane-bounded organelle intracellular anatomical structure organelle subcompartment intracellular membrane-bounded organelle endomembrane system sarcoplasm endoplasmic reticulum subcompartment intracellular organelle bounding membrane of organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum sarcoplasmic reticulum sarcoplasmic reticulum membrane cytoplasm organelle membrane endoplasmic reticulum membrane mitochondrial membrane mitochondrion organelle envelope mitochondrial envelope

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR005984	Phospholamban	Family

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A	OPM	Transmembrane	Bitopic proteins	Single-helix ATPase regulators	Calcium ATPase regulators

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	P-type ATPase	Phospholamban homopentamer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.