Annotations: 1G0Y

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A [auth R]	d1g0yr1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	I set domains	Type-1 interleukin-1 receptor	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B [auth I]	d1g0yi_	Designed proteins	IL-1 receptor type 1 antagonist peptide AF10847	IL-1 receptor type 1 antagonist peptide AF10847	IL-1 receptor type 1 antagonist peptide AF10847	IL-1 receptor type 1 antagonist peptide AF10847	( ) [TaxId: ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth R]	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8055560	3000071	SCOP2B (2022-06-29)
A [auth R]	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054779	3000071	SCOP2B (2022-06-29)
A [auth R]	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8055562	3000071	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth R]	I-set_4	e1g0yR2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: I-set_4	ECOD (1.6)
A [auth R]	I-set_5	e1g0yR1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: I-set_5	ECOD (1.6)
A [auth R]	I-set	e1g0yR3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: I-set	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth R]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth R]	PF13895	Immunoglobulin domain (Ig_2)	Immunoglobulin domain	This domain contains immunoglobulin-like domains.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth R]	INTERLEUKIN-1 RECEPTOR, TYPE I	hydrolase activity, acting on glycosyl bonds NAD+ nucleosidase activity, cyclic ADP-ribose generating hydrolase activity hydrolase activity, hydrolyzing N-glycosyl compounds catalytic activity protein binding binding signaling receptor binding platelet-derived growth factor receptor binding growth factor receptor binding enzyme binding protease binding interleukin-1 binding growth factor binding hydrolase activity, acting on glycosyl bonds NAD+ nucleosidase activity, cyclic ADP-ribose generating hydrolase activity hydrolase activity, hydrolyzing N-glycosyl compounds catalytic activity protein binding binding signaling receptor binding platelet-derived growth factor receptor binding growth factor receptor binding enzyme binding protease binding interleukin-1 binding growth factor binding cytokine binding interleukin-1, type I, activating receptor activity molecular transducer activity transmembrane signaling receptor activity signaling receptor activity cytokine receptor activity immune receptor activity interleukin-1 receptor activity NAD+ nucleosidase activity	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains multicellular organismal process regulation of immune effector process lymphocyte mediated immunity T cell mediated immunity positive regulation of leukocyte mediated immunity regulation of cellular process response to stimulus T cell cytokine production positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of immune response T-helper 1 cell cytokine production cytokine production adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains multicellular organismal process regulation of immune effector process lymphocyte mediated immunity T cell mediated immunity positive regulation of leukocyte mediated immunity regulation of cellular process response to stimulus T cell cytokine production positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of immune response T-helper 1 cell cytokine production cytokine production leukocyte mediated immunity regulation of immune system process positive regulation of macromolecule metabolic process positive regulation of adaptive immune response positive regulation of T cell cytokine production positive regulation of immune system process regulation of T cell mediated immunity regulation of biological process regulation of cytokine production involved in immune response immune response regulation of adaptive immune response T-helper 1 type immune response regulation of T-helper 1 type immune response immune effector process regulation of gene expression regulation of leukocyte mediated immunity biosynthetic process regulation of response to stimulus positive regulation of production of molecular mediator of immune response positive regulation of multicellular organismal process regulation of immune response metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of production of molecular mediator of immune response positive regulation of cytokine production regulation of metabolic process positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of lymphocyte mediated immunity positive regulation of T-helper 1 cell cytokine production positive regulation of biological process regulation of T-helper 1 cell cytokine production positive regulation of response to stimulus regulation of T cell cytokine production CD4-positive, alpha-beta T cell cytokine production regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of biosynthetic process regulation of cytokine production positive regulation of immune effector process regulation of multicellular organismal process cytokine production involved in immune response positive regulation of cellular process production of molecular mediator of immune response regulation of biosynthetic process positive regulation of T-helper 1 type immune response biological regulation regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process adaptive immune response regulation of lymphocyte mediated immunity positive regulation of gene expression immune system process positive regulation of T cell mediated immunity positive regulation of cytokine production involved in immune response cellular process positive regulation of locomotion regulation of cell motility regulation of neutrophil extravasation positive regulation of cell migration positive regulation of cell motility myeloid leukocyte migration cellular extravasation regulation of cell migration cell migration cell motility locomotion neutrophil extravasation regulation of leukocyte migration positive regulation of leukocyte migration positive regulation of neutrophil migration neutrophil migration granulocyte migration leukocyte migration positive regulation of neutrophil extravasation regulation of locomotion regulation of neutrophil migration positive regulation of cellular extravasation regulation of cellular extravasation response to peptide response to chemical response to cytokine response to interleukin-1 cellular response to stimulus positive regulation of cell communication positive regulation of signal transduction signaling regulation of signal transduction positive regulation of response to cytokine stimulus cytokine-mediated signaling pathway cell communication cellular response to cytokine stimulus signal transduction regulation of interleukin-1-mediated signaling pathway regulation of signaling cell surface receptor signaling pathway regulation of cytokine-mediated signaling pathway cellular response to interleukin-1 regulation of response to cytokine stimulus interleukin-1-mediated signaling pathway positive regulation of interleukin-1-mediated signaling pathway regulation of cell communication positive regulation of cytokine-mediated signaling pathway positive regulation of signaling regulation of defense response regulation of response to external stimulus defense response regulation of inflammatory response response to external stimulus response to stress regulation of response to stress inflammatory response regulation of type II interferon production type II interferon production positive regulation of type II interferon production	cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane extracellular region
B [auth I]	ANTAGONIST PEPTIDE AF10847	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth R]	IPR000157	Toll/interleukin-1 receptor homology (TIR) domain	Domain
A [auth R]	IPR004074	Interleukin-1 receptor type I/II	Family
A [auth R]	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A [auth R]	IPR003599	Immunoglobulin domain subtype	Domain
A [auth R]	IPR041416	IL-1Ra-like, immunoglobulin domain	Domain
A [auth R]	IPR004076	Interleukin-1 receptor type 1	Family
A [auth R]	IPR015621	Interleukin-1 receptor family	Family
A [auth R]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A [auth R]	IPR035897	Toll/interleukin-1 receptor homology (TIR) domain superfamily	Homologous Superfamily
A [auth R]	IPR007110	Immunoglobulin-like domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth R]	Pharos: P14778	endometriosis allergic disease ulcerative colitis pneumonia dermatomyositis psoriasis subependymal giant cell astrocytoma Gaucher disease interstitial cystitis adenoma Lobar Pneumonia malignant ependymoma asthma MALT lymphoma oligodendroglioma endometriosis allergic disease ulcerative colitis pneumonia dermatomyositis psoriasis subependymal giant cell astrocytoma Gaucher disease interstitial cystitis adenoma Lobar Pneumonia malignant ependymoma asthma MALT lymphoma oligodendroglioma breast cancer pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma cystic fibrosis pneumonitis rheumatoid arthritis Duchenne muscular dystrophy tuberculosis juvenile dermatomyositis adrenal cortex carcinoma lung cancer ankylosing spondylitis malignant mesothelioma autoimmune disease medulloblastoma brain injury ovarian cancer pancreatic intraductal papillary-mucinous neoplasm Crohn disease pituitary cancer primary biliary cholangitis skin disease large cell medulloblastoma lung carcinoma arthritic joint disease malignant pancreatic neoplasm myopathy pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.