Annotations: 1G6Z

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1g6za1	All beta proteins	SH3-like barrel	Chromo domain-like	Chromo domain	Histone methyltransferase clr4, chromo domain	fission yeast (Schizosaccharomyces pombe ) [TaxId: 4896 ],	SCOPe (2.08)
A	d1g6za2	Artifacts	Tags	Tags	Tags	N-terminal Tags	fission yeast (Schizosaccharomyces pombe ) [TaxId: 4896 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Chromo domain	8020249	4000375	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Chromo domain-like	8032629	3000161	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Chromo	e1g6zA1	A: beta barrels	X: SH3	H: Chromo domain-like (From Topology)	T: Chromo domain-like	F: Chromo	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.40.50.40	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00385	Chromo (CHRromatin Organisation MOdifier) domain (Chromo)	Chromo (CHRromatin Organisation MOdifier) domain		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	CLR4 PROTEIN	protein-lysine N-methyltransferase activity histone H3 methyltransferase activity catalytic activity, acting on a protein transferase activity, transferring one-carbon groups histone H3K9 methyltransferase activity transferase activity histone H3K9 trimethyltransferase activity S-adenosylmethionine-dependent methyltransferase activity histone methyltransferase activity lysine N-methyltransferase activity protein methyltransferase activity histone modifying activity N-methyltransferase activity methyltransferase activity catalytic activity protein-lysine N-methyltransferase activity histone H3 methyltransferase activity catalytic activity, acting on a protein transferase activity, transferring one-carbon groups histone H3K9 methyltransferase activity transferase activity histone H3K9 trimethyltransferase activity S-adenosylmethionine-dependent methyltransferase activity histone methyltransferase activity lysine N-methyltransferase activity protein methyltransferase activity histone modifying activity N-methyltransferase activity methyltransferase activity catalytic activity histone H3K9 monomethyltransferase activity ubiquitin-modified protein reader activity ubiquitin-modified histone reader activity histone reader activity chromatin-protein adaptor activity protein-macromolecule adaptor activity ubiquitin-like protein reader activity molecular adaptor activity RNA binding binding nucleic acid binding single-stranded RNA binding protein binding ubiquitin binding ubiquitin-like protein binding histone H3K9me2 methyltransferase activity DNA binding double-stranded DNA binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding single-stranded DNA binding	positive regulation of organelle organization regulation of cellular process negative regulation of biological process cellular component biogenesis chromatin organization regulation of heterochromatin formation regulation of biological process regulation of chromatin organization negative regulation of metabolic process regulation of chromosome organization regulation of organelle organization positive regulation of chromosome organization regulation of gene expression negative regulation of gene expression positive regulation of organelle organization regulation of cellular process negative regulation of biological process cellular component biogenesis chromatin organization regulation of heterochromatin formation regulation of biological process regulation of chromatin organization negative regulation of metabolic process regulation of chromosome organization regulation of organelle organization positive regulation of chromosome organization regulation of gene expression negative regulation of gene expression constitutive heterochromatin formation biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process regulation of cellular component organization positive regulation of cellular component organization positive regulation of biological process cellular component organization positive regulation of heterochromatin formation regulation of pericentric heterochromatin formation negative regulation of cellular process chromatin remodeling positive regulation of chromatin organization cellular component organization or biogenesis positive regulation of cellular process negative regulation of macromolecule metabolic process regulation of biosynthetic process positive regulation of pericentric heterochromatin formation heterochromatin formation positive regulation of cellular component biogenesis epigenetic regulation of gene expression biological regulation chromosome organization regulation of macromolecule metabolic process gene expression regulation of cellular component biogenesis macromolecule biosynthetic process pericentric heterochromatin formation organelle organization negative regulation of biosynthetic process cellular process siRNA-independent facultative heterochromatin formation facultative heterochromatin formation methylation nuclear polyadenylation-dependent antisense transcript catabolic process nuclear RNA surveillance catabolic process RNA metabolic process antisense RNA transcript catabolic process primary metabolic process nucleic acid metabolic process macromolecule catabolic process nucleobase-containing compound catabolic process nucleobase-containing compound metabolic process nucleic acid catabolic process antisense RNA metabolic process RNA surveillance RNA catabolic process silent mating-type cassette heterochromatin formation siRNA-mediated heterochromatin formation siRNA-mediated pericentric heterochromatin formation regulatory ncRNA-mediated gene silencing regulatory ncRNA-mediated heterochromatin formation subtelomeric heterochromatin formation co-transcriptional gene silencing by RNA interference machinery	intracellular anatomical structure chromosome, subtelomeric region intracellular membraneless organelle chromatin chromosome heterochromatin chromosomal region intracellular organelle cellular anatomical structure organelle membraneless organelle chromosome, telomeric region subtelomeric heterochromatin mating-type region heterochromatin intracellular anatomical structure chromosome, subtelomeric region intracellular membraneless organelle chromatin chromosome heterochromatin chromosomal region intracellular organelle cellular anatomical structure organelle membraneless organelle chromosome, telomeric region subtelomeric heterochromatin mating-type region heterochromatin membrane-bounded organelle protein-containing complex ubiquitin ligase complex nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen CLRC complex cullin-RING ubiquitin ligase complex nucleoplasm methyltransferase complex histone methyltransferase complex catalytic complex Cul4-RING E3 ubiquitin ligase complex intracellular membrane-bounded organelle nuclear ubiquitin ligase complex organelle lumen intracellular protein-containing complex nuclear lumen cytoplasm pericentric heterochromatin chromosome, centromeric region microtubule organizing center cytoskeleton spindle pole body microtubule cytoskeleton

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR007728	Pre-SET domain	Domain
A	IPR046341	SET domain superfamily	Homologous Superfamily
A	IPR023780	Chromo domain	Domain
A	IPR050973	Histone-lysine N-methyltransferase, H3 Lys-9 specific	Family
A	IPR001214	SET domain	Domain
A	IPR016197	Chromo-like domain superfamily	Homologous Superfamily
A	IPR023779	Chromo domain, conserved site	Conserved Site
A	IPR011381	Histone-lysine N-methyltransferase SUV39H1/2-like	Family
A	IPR003616	Post-SET domain	Domain
A	IPR000953	Chromo/chromo shadow domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.