Annotations: 1HNS

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1hnsa_	All alpha proteins	H-NS histone-like proteins	H-NS histone-like proteins	H-NS histone-like proteins	H1 protein (H-NS)	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	H-NS histone-like proteins	8037682	3000427	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Histone_HNS	e1hnsA1	A: few secondary structure elements	X: H-NS histone-like proteins, C-terminal domain (From Topology)	H: H-NS histone-like proteins, C-terminal domain (From Topology)	T: H-NS histone-like proteins, C-terminal domain	F: Histone_HNS	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	4.10.430.10	Few Secondary Structures	Irregular	H-NS DNA Binding Protein	Histone-like protein H-NS, C-terminal domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00816	H-NS histone C-terminal domain (Histone_HNS)	H-NS histone C-terminal domain	This entry represents the C-terminal DNA binding domain of H-NS histone protein.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	H-NS	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding nucleic acid binding transcription regulatory region nucleic acid binding RNA binding structural molecule activity structural constituent of chromatin transcription regulator activity DNA-binding transcription repressor activity DNA-binding transcription factor activity DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding nucleic acid binding transcription regulatory region nucleic acid binding RNA binding structural molecule activity structural constituent of chromatin transcription regulator activity DNA-binding transcription repressor activity DNA-binding transcription factor activity bent DNA binding DNA secondary structure binding minor groove of adenine-thymine-rich DNA binding protein binding protein dimerization activity identical protein binding	regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of DNA-templated transcription regulation of biological process negative regulation of metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular component organization organelle organization bacterial nucleoid packaging chromosome organization cellular component organization or biogenesis regulation of protein metabolic process translation post-transcriptional regulation of gene expression regulation of translation protein metabolic process cell aggregation biofilm formation regulation of single-species biofilm formation on inanimate substrate biological process involved in intraspecies interaction between organisms single-species biofilm formation on inanimate substrate single-species biofilm formation aggregation of unicellular organisms submerged biofilm formation negative regulation of single-species biofilm formation negative regulation of single-species biofilm formation on inanimate substrate regulation of single-species biofilm formation single-species submerged biofilm formation	bacterial nucleoid protein-containing complex intracellular anatomical structure intracellular membraneless organelle nucleoid DNA bending complex H-NS complex intracellular organelle cellular anatomical structure organelle membraneless organelle cytoplasm cytosol membrane bacterial nucleoid protein-containing complex intracellular anatomical structure intracellular membraneless organelle nucleoid DNA bending complex H-NS complex intracellular organelle cellular anatomical structure organelle membraneless organelle cytoplasm cytosol membrane transcription regulator complex H-NS-Cnu complex transcription repressor complex H-NS-Hha complex protein-DNA complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR027444	DNA-binding protein H-NS-like, C-terminal domain	Domain
A	IPR037150	Histone-like protein H-NS, C-terminal domain superfamily	Homologous Superfamily
A	IPR001801	DNA-binding protein H-NS-like	Family
A	IPR027454	Histone-like protein H-NS, N-terminal	Homologous Superfamily
A	IPR054180	DNA-binding protein H-NS-like, N-terminal domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.