1L3H | pdb_00001l3h

NMR structure of P41icf, a potent inhibitor of human cathepsin L

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1l3ha_	Small proteins	Thyroglobulin type-1 domain	Thyroglobulin type-1 domain	Thyroglobulin type-1 domain	Class II MHC associated p41 invariant chain fragment	( ) [TaxId: ], (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Thyroglobulin type-1 domain	8038982	3000991	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Thyroglobulin_1	e1l3hA1	A: few secondary structure elements	X: Thyroglobulin type-1 domain (From Topology)	H: Thyroglobulin type-1 domain (From Topology)	T: Thyroglobulin type-1 domain	F: Thyroglobulin_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	4.10.800.10	Few Secondary Structures	Irregular	Invariant Chain	Chain I	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00086	Thyroglobulin type-1 repeat (Thyroglobulin_1)	Thyroglobulin type-1 repeat	Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation [2]. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	MHC CLASS II-ASSOCIATED P41 INVARIANT CHAIN FRAGMENT (P41icf)	amide binding amyloid-beta binding binding peptide binding protein-containing complex binding MHC protein complex binding MHC class II protein complex binding nitric-oxide synthase binding protein binding enzyme binding macrophage migration inhibitory factor binding cytokine binding identical protein binding signaling receptor binding amide binding amyloid-beta binding binding peptide binding protein-containing complex binding MHC protein complex binding MHC class II protein complex binding nitric-oxide synthase binding protein binding enzyme binding macrophage migration inhibitory factor binding cytokine binding identical protein binding signaling receptor binding MHC class II protein binding MHC protein binding MHC class II protein binding, via antigen binding groove molecular transducer activity transmembrane signaling receptor activity signaling receptor activity cytokine receptor activity immune receptor activity CD4 receptor binding protein folding chaperone	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity response to stimulus immune response immune system process B cell mediated immunity leukocyte mediated immunity immunoglobulin mediated immune response adaptive immune response immune effector process developmental process thymic T cell selection multicellular organismal process cellular developmental process adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity response to stimulus immune response immune system process B cell mediated immunity leukocyte mediated immunity immunoglobulin mediated immune response adaptive immune response immune effector process developmental process thymic T cell selection multicellular organismal process cellular developmental process hemopoiesis cell activation cell development mononuclear cell differentiation lymphocyte activation lymphocyte differentiation leukocyte activation T cell differentiation in thymus T cell activation cell differentiation negative thymic T cell selection anatomical structure development T cell differentiation cellular process negative T cell selection T cell selection leukocyte differentiation regulation of protein stability biological regulation regulation of biological quality protein stabilization antigen processing and presentation antigen processing and presentation of endogenous antigen cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein trimerization protein complex oligomerization protein-containing complex assembly cellular component organization or biogenesis regulation of biosynthetic process regulation of biological process regulation of cellular process positive regulation of biological process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process positive regulation of macromolecule biosynthetic process regulation of gene expression positive regulation of metabolic process biosynthetic process positive regulation of gene expression positive regulation of biosynthetic process regulation of macromolecule biosynthetic process metabolic process positive regulation of macromolecule metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular process regulation of B cell apoptotic process homeostatic process leukocyte apoptotic process negative regulation of biological process regulation of programmed cell death lymphocyte apoptotic process negative regulation of leukocyte apoptotic process negative regulation of mature B cell apoptotic process negative regulation of cellular process regulation of immune system process regulation of leukocyte apoptotic process regulation of lymphocyte apoptotic process mature B cell apoptotic process negative regulation of programmed cell death regulation of apoptotic process B cell apoptotic process cell death negative regulation of B cell apoptotic process B cell homeostasis negative regulation of apoptotic process multicellular organismal-level homeostasis leukocyte homeostasis homeostasis of number of cells regulation of mature B cell apoptotic process lymphocyte homeostasis apoptotic process programmed cell death negative regulation of lymphocyte apoptotic process regulation of leukocyte differentiation regulation of leukocyte activation regulation of cell activation regulation of cell differentiation regulation of cell development negative regulation of cell adhesion multicellular organism development negative regulation of T cell differentiation negative regulation of hemopoiesis negative regulation of leukocyte differentiation negative regulation of T cell activation negative regulation of leukocyte cell-cell adhesion negative regulation of cell-cell adhesion negative regulation of lymphocyte differentiation regulation of leukocyte cell-cell adhesion negative regulation of multicellular organismal process negative regulation of leukocyte activation regulation of developmental process negative regulation of lymphocyte activation leukocyte cell-cell adhesion regulation of T cell differentiation cell adhesion cell-cell adhesion regulation of multicellular organismal process negative regulation of cell differentiation regulation of cell-cell adhesion regulation of lymphocyte differentiation regulation of multicellular organismal development negative regulation of developmental process regulation of cell adhesion regulation of T cell activation negative regulation of cell activation negative regulation of cell development negative regulation of immune system process regulation of hemopoiesis regulation of lymphocyte activation cellular response to stimulus positive regulation of cell communication positive regulation of signal transduction signaling response to cytokine regulation of signal transduction positive regulation of response to cytokine stimulus cytokine-mediated signaling pathway cell communication positive regulation of response to stimulus cellular response to cytokine stimulus signal transduction regulation of signaling cell surface receptor signaling pathway regulation of cytokine-mediated signaling pathway response to peptide regulation of response to cytokine stimulus regulation of response to stimulus response to chemical regulation of cell communication positive regulation of cytokine-mediated signaling pathway positive regulation of signaling positive regulation of phosphorylation regulation of catalytic activity positive regulation of phosphate metabolic process regulation of transferase activity positive regulation of molecular function regulation of phosphate metabolic process phosphate-containing compound metabolic process phosphorus metabolic process positive regulation of transferase activity positive regulation of phosphorus metabolic process phosphorylation positive regulation of catalytic activity regulation of molecular function positive regulation of kinase activity regulation of kinase activity regulation of phosphorus metabolic process regulation of phosphorylation regulation of macrophage activation myeloid leukocyte activation macrophage activation chemokine (C-X-C motif) ligand 2 production regulation of chemokine (C-X-C motif) ligand 2 production cytokine production regulation of cytokine production positive regulation of chemokine (C-X-C motif) ligand 2 production regulation of chemokine production chemokine production positive regulation of chemokine production positive regulation of multicellular organismal process positive regulation of cytokine production prostaglandin metabolic process unsaturated fatty acid metabolic process oxoacid metabolic process regulation of lipid metabolic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process regulation of primary metabolic process regulation of small molecule metabolic process positive regulation of lipid metabolic process positive regulation of prostaglandin biosynthetic process small molecule metabolic process prostaglandin biosynthetic process primary metabolic process regulation of ketone metabolic process regulation of fatty acid metabolic process regulation of fatty acid biosynthetic process monocarboxylic acid metabolic process positive regulation of unsaturated fatty acid biosynthetic process regulation of prostaglandin biosynthetic process icosanoid metabolic process ketone metabolic process regulation of unsaturated fatty acid biosynthetic process lipid biosynthetic process positive regulation of fatty acid biosynthetic process prostanoid metabolic process icosanoid biosynthetic process prostanoid biosynthetic process positive regulation of fatty acid metabolic process fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process carboxylic acid metabolic process fatty acid biosynthetic process unsaturated fatty acid biosynthetic process positive regulation of lipid biosynthetic process regulation of lipid biosynthetic process positive regulation of small molecule metabolic process lipid metabolic process positive regulation of interleukin-8 production interleukin-8 production regulation of interleukin-8 production biological process involved in interspecies interaction between organisms response to other organism defense response response to type II interferon defense response to symbiont response to external stimulus response to biotic stimulus defense response to other organism response to stress innate immune response response to external biotic stimulus negative regulation of locomotion regulation of cell motility regulation of locomotion regulation of cell migration negative regulation of cell motility cell migration cell motility negative regulation of cell migration locomotion chaperone cofactor-dependent protein refolding chaperone-mediated protein folding protein maturation protein folding protein metabolic process 'de novo' protein folding 'de novo' post-translational protein folding myeloid leukocyte differentiation positive regulation of monocyte differentiation positive regulation of developmental process positive regulation of cell differentiation positive regulation of hemopoiesis monocyte differentiation positive regulation of immune system process regulation of monocyte differentiation regulation of myeloid cell differentiation positive regulation of cell development regulation of myeloid leukocyte differentiation positive regulation of myeloid leukocyte differentiation myeloid cell differentiation positive regulation of myeloid cell differentiation positive regulation of leukocyte differentiation regulation of immune effector process positive regulation of myeloid leukocyte cytokine production involved in immune response positive regulation of immune effector process myeloid leukocyte cytokine production cytokine production involved in immune response production of molecular mediator of immune response regulation of cytokine production involved in immune response regulation of macrophage cytokine production positive regulation of cytokine production involved in immune response positive regulation of production of molecular mediator of immune response regulation of production of molecular mediator of immune response positive regulation of macrophage cytokine production macrophage cytokine production positive regulation of viral life cycle positive regulation of viral process viral life cycle modulation by symbiont of entry into host biological process involved in interaction with host biological process involved in symbiotic interaction regulation of viral entry into host cell regulation of viral life cycle regulation of viral process symbiont entry into host cell viral process symbiont entry into host positive regulation of viral entry into host cell positive regulation by symbiont of entry into host regulation of biological process involved in symbiotic interaction positive regulation of cell population proliferation positive regulation of B cell proliferation leukocyte proliferation positive regulation of lymphocyte activation positive regulation of cell activation regulation of B cell proliferation lymphocyte proliferation regulation of B cell activation positive regulation of leukocyte activation positive regulation of mononuclear cell proliferation regulation of lymphocyte proliferation regulation of leukocyte proliferation cell population proliferation B cell activation positive regulation of lymphocyte proliferation B cell proliferation positive regulation of B cell activation regulation of cell population proliferation mononuclear cell proliferation positive regulation of leukocyte proliferation regulation of mononuclear cell proliferation cell activation involved in immune response T cell activation involved in immune response leukocyte activation involved in immune response lymphocyte activation involved in immune response macrophage migration inhibitory factor signaling pathway positive regulation of canonical NF-kappaB signal transduction intracellular signal transduction regulation of intracellular signal transduction intracellular signaling cassette positive regulation of intracellular signal transduction canonical NF-kappaB signal transduction regulation of canonical NF-kappaB signal transduction positive regulation of ERK1 and ERK2 cascade positive regulation of MAPK cascade regulation of MAPK cascade MAPK cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade interleukin-6 production positive regulation of interleukin-6 production regulation of interleukin-6 production fibroblast proliferation regulation of fibroblast proliferation positive regulation of fibroblast proliferation positive thymic T cell selection positive T cell selection negative regulation of signaling negative regulation of intracellular signal transduction regulation of cellular response to stress DNA damage response, signal transduction by p53 class mediator negative regulation of cell communication cellular response to stress regulation of response to stress regulation of signal transduction by p53 class mediator negative regulation of DNA damage response, signal transduction by p53 class mediator regulation of DNA damage response, signal transduction by p53 class mediator negative regulation of signal transduction by p53 class mediator negative regulation of response to stimulus signal transduction by p53 class mediator negative regulation of signal transduction DNA damage response signal transduction in response to DNA damage antigen processing and presentation of exogenous peptide antigen via MHC class II antigen processing and presentation of peptide or polysaccharide antigen via MHC class II antigen processing and presentation of peptide antigen via MHC class II antigen processing and presentation of exogenous peptide antigen antigen processing and presentation of peptide antigen antigen processing and presentation of exogenous antigen positive regulation of type 2 immune response type 2 immune response positive regulation of immune response regulation of type 2 immune response regulation of immune response positive regulation of locomotion positive regulation of chemotaxis positive regulation of cell migration positive regulation of neutrophil chemotaxis taxis chemotaxis regulation of leukocyte chemotaxis regulation of leukocyte migration positive regulation of leukocyte chemotaxis neutrophil migration granulocyte migration leukocyte migration positive regulation of granulocyte chemotaxis regulation of neutrophil chemotaxis regulation of neutrophil migration regulation of response to external stimulus neutrophil chemotaxis regulation of granulocyte chemotaxis positive regulation of response to external stimulus positive regulation of cell motility myeloid leukocyte migration cell chemotaxis positive regulation of leukocyte migration positive regulation of neutrophil migration regulation of chemotaxis cellular response to chemical stimulus granulocyte chemotaxis leukocyte chemotaxis host-mediated suppression of symbiont invasion host-mediated perturbation of symbiont process modulation of process of another organism protein localization cellular localization establishment of protein localization nitrogen compound transport transport intracellular transport establishment of localization localization protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization intracellular protein transport positive regulation of macrophage migration inhibitory factor signaling pathway regulation of macrophage migration inhibitory factor signaling pathway regulation of intrinsic apoptotic signaling pathway in response to DNA damage regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator negative regulation of apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway by p53 class mediator regulation of apoptotic signaling pathway regulation of intrinsic apoptotic signaling pathway intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator regulation of intrinsic apoptotic signaling pathway by p53 class mediator positive regulation of DNA-templated transcription RNA metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process positive regulation of nucleobase-containing compound metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of DNA-templated transcription regulation of localization regulation of peptide secretion regulation of transport secretion regulation of peptide transport negative regulation of transport negative regulation of peptide secretion regulation of secretion peptide transport peptide secretion negative regulation of secretion amide transport regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of protein modification process positive regulation of protein phosphorylation protein modification process protein phosphorylation regulation of protein metabolic process macromolecule modification regulation of dendritic cell antigen processing and presentation positive regulation of dendritic cell antigen processing and presentation positive regulation of antigen processing and presentation regulation of antigen processing and presentation dendritic cell antigen processing and presentation positive regulation of T cell differentiation positive regulation of T cell activation positive regulation of leukocyte cell-cell adhesion positive regulation of cell-cell adhesion positive regulation of cell adhesion positive regulation of lymphocyte differentiation	cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular organelle bounding membrane of organelle cytoplasmic vesicle vesicle membrane cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular organelle bounding membrane of organelle cytoplasmic vesicle vesicle membrane clathrin-coated vesicle endocytic vesicle membrane coated vesicle vesicle endocytic vesicle clathrin-coated vesicle membrane clathrin-coated endocytic vesicle membrane intracellular membrane-bounded organelle clathrin-coated endocytic vesicle cytoplasmic vesicle membrane coated vesicle membrane organelle cytoplasm organelle membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle vacuolar membrane lytic vacuole vacuole lytic vacuole membrane lysosomal membrane lysosome Golgi membrane Golgi apparatus endomembrane system transport vesicle transport vesicle membrane membrane-enclosed lumen vacuolar lumen lysosomal lumen intracellular organelle lumen organelle lumen MHC protein complex MHC class II protein complex protein-containing complex plasma membrane protein complex membrane protein complex macrophage migration inhibitory factor receptor complex receptor complex endosome late endosome multivesicular body organelle subcompartment lumenal side of endoplasmic reticulum membrane lumenal side of membrane endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum endoplasmic reticulum membrane NOS2-CD74 complex Golgi apparatus subcompartment trans-Golgi network membrane trans-Golgi network COPII-coated ER to Golgi transport vesicle ER to Golgi transport vesicle membrane nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR022339	MHC class II-associated invariant chain	Family
A	IPR000716	Thyroglobulin type-1	Domain
A	IPR043530	HLA class II histocompatibility antigen, gamma subunit	Family
A	IPR015386	MHC class II-associated invariant chain/CLIP, MHC II-interacting	Domain
A	IPR036613	MHC class II-associated invariant chain, trimerisation domain superfamily	Homologous Superfamily
A	IPR036857	Thyroglobulin type-1 superfamily	Homologous Superfamily
A	IPR011988	MHC class II-associated invariant chain, trimerisation	Domain
A	IPR052001	MHC Class II Gamma Chain/Thyroglobulin	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P04233	non-small cell lung carcinoma acute liver failure breast cancer breast carcinoma Liver Cirrhosis, Experimental malignant ependymoma osteosarcoma pilocytic astrocytoma Sjogren syndrome astrocytic tumor Down syndrome glioblastoma juvenile dermatomyositis lung cancer malignant glioma non-small cell lung carcinoma acute liver failure breast cancer breast carcinoma Liver Cirrhosis, Experimental malignant ependymoma osteosarcoma pilocytic astrocytoma Sjogren syndrome astrocytic tumor Down syndrome glioblastoma juvenile dermatomyositis lung cancer malignant glioma ovarian cancer psoriasis acute myeloid leukemia subependymal giant cell astrocytoma atypical teratoid rhabdoid tumor Duchenne muscular dystrophy interstitial cystitis limb-girdle muscular dystrophy lung carcinoma pancreatic ductal adenocarcinoma rheumatoid arthritis ulcerative colitis adrenal cortex carcinoma Becker muscular dystrophy Crohn disease esophageal adenocarcinoma invasive ductal breast carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.