1LXF | pdb_00001lxf

Structure of the Regulatory N-domain of Human Cardiac Troponin C in Complex with Human Cardiac Troponin-I(147-163) and Bepridil

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A [auth C]	d1lxfc_	All alpha proteins	EF Hand-like	EF-hand	Calmodulin-like	Troponin C	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B [auth I]	d1lxfi_	Peptides	Troponin I fragments	Troponin I fragments	Troponin I fragments	Troponin I fragments	( ) [TaxId: ], (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth C]	EF-hand_7_5	e1lxfC1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_5	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth C]	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth C]	PF13833	EF-hand domain pair (EF-hand_8)	EF-hand domain pair		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth C]	TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES	cytoskeletal protein binding protein binding binding troponin T binding cation binding ion binding calcium ion binding metal ion binding small molecule binding actin binding protein-containing complex binding actin filament binding identical protein binding protein homodimerization activity cytoskeletal protein binding protein binding binding troponin T binding cation binding ion binding calcium ion binding metal ion binding small molecule binding actin binding protein-containing complex binding actin filament binding identical protein binding protein homodimerization activity protein dimerization activity calcium-dependent protein binding troponin I binding	multicellular organismal process system process nervous system process neuromuscular process skeletal muscle contraction muscle contraction respiratory gaseous exchange by respiratory system muscle system process striated muscle contraction multicellular organismal movement musculoskeletal movement diaphragm contraction respiratory system process involuntary skeletal muscle contraction multicellular organismal process system process nervous system process neuromuscular process skeletal muscle contraction muscle contraction respiratory gaseous exchange by respiratory system muscle system process striated muscle contraction multicellular organismal movement musculoskeletal movement diaphragm contraction respiratory system process involuntary skeletal muscle contraction regulation of biological process regulation of muscle contraction regulation of system process biological regulation regulation of multicellular organismal process regulation of muscle system process regulation of muscle adaptation striated muscle adaptation response to stimulus transition between fast and slow fiber regulation of skeletal muscle adaptation muscle adaptation regulation of response to stimulus skeletal muscle adaptation heart process circulatory system process cardiac muscle contraction heart contraction blood circulation response to metal ion response to chemical regulation of ATP-dependent activity regulation of molecular function ventricular cardiac muscle tissue morphogenesis heart morphogenesis striated muscle tissue development muscle structure development multicellular organism development ventricular cardiac muscle tissue development anatomical structure development cardiac chamber development animal organ morphogenesis muscle tissue development muscle organ development system development developmental process heart development cardiac chamber morphogenesis cardiac muscle tissue development animal organ development tissue development muscle tissue morphogenesis circulatory system development anatomical structure morphogenesis tissue morphogenesis cardiac ventricle morphogenesis cardiac muscle tissue morphogenesis cardiac ventricle development muscle organ morphogenesis regulation of localization cellular localization regulation of cellular process regulation of actin filament-based process transport muscle filament sliding localization establishment of localization in cell actin filament-based process regulation of biological quality regulation of intracellular transport actin-myosin filament sliding regulation of transport regulation of muscle filament sliding speed intracellular transport actin filament-based movement establishment of localization regulation of cellular localization regulation of actin filament-based movement cellular process regulation of muscle filament sliding actin-mediated cell contraction	striated muscle thin filament protein-containing complex intracellular anatomical structure myofilament intracellular membraneless organelle actin cytoskeleton sarcomere intracellular organelle cellular anatomical structure troponin complex cytoskeleton organelle membraneless organelle contractile muscle fiber striated muscle thin filament protein-containing complex intracellular anatomical structure myofilament intracellular membraneless organelle actin cytoskeleton sarcomere intracellular organelle cellular anatomical structure troponin complex cytoskeleton organelle membraneless organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex cytosol cardiac Troponin complex
B [auth I]	Troponin I, cardiac muscle	protein binding binding protein domain specific binding cytoskeletal protein binding actin binding protein-containing complex binding actin filament binding troponin C binding troponin T binding kinase binding enzyme binding protein kinase binding monoatomic cation transmembrane transporter activity channel regulator activity protein binding binding protein domain specific binding cytoskeletal protein binding actin binding protein-containing complex binding actin filament binding troponin C binding troponin T binding kinase binding enzyme binding protein kinase binding monoatomic cation transmembrane transporter activity channel regulator activity monoatomic ion channel activity molecular function inhibitor activity passive transmembrane transporter activity transporter inhibitor activity calcium channel inhibitor activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity molecular function regulator activity transporter activity channel inhibitor activity calcium channel activity ion channel inhibitor activity ion channel regulator activity calcium channel regulator activity monoatomic cation channel activity calcium ion transmembrane transporter activity channel activity monoatomic ion transmembrane transporter activity metal ion transmembrane transporter activity transporter regulator activity transmembrane transporter activity calcium-dependent protein binding	developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development negative regulation of ATP-dependent activity regulation of ATP-dependent activity regulation of molecular function biological regulation negative regulation of molecular function multicellular organismal movement developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development negative regulation of ATP-dependent activity regulation of ATP-dependent activity regulation of molecular function biological regulation negative regulation of molecular function multicellular organismal movement musculoskeletal movement system process nervous system process neuromuscular process skeletal muscle contraction muscle contraction muscle system process striated muscle contraction inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process calcium ion homeostasis cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis regulation of biological process regulation of system process regulation of muscle system process smooth muscle contraction regulation of smooth muscle contraction regulation of muscle contraction regulation of multicellular organismal process heart process circulatory system process heart contraction blood circulation cellular developmental process blood vessel morphogenesis tube development vasculogenesis vasculature development anatomical structure morphogenesis tube morphogenesis cell differentiation cellular process blood vessel development regulation of systemic arterial blood pressure by ischemic conditions regulation of blood pressure regulation of systemic arterial blood pressure regulation of biological quality nervous system process involved in regulation of systemic arterial blood pressure cardiac muscle contraction ventricular cardiac muscle tissue morphogenesis heart morphogenesis striated muscle tissue development muscle structure development ventricular cardiac muscle tissue development cardiac chamber development animal organ morphogenesis muscle tissue development muscle organ development cardiac chamber morphogenesis cardiac muscle tissue development tissue development muscle tissue morphogenesis tissue morphogenesis cardiac ventricle morphogenesis cardiac muscle tissue morphogenesis cardiac ventricle development muscle organ morphogenesis cellular response to stimulus regulation of cellular process response to stimulus signaling regulation of heart contraction intracellular signal transduction cell communication intracellular signaling cassette signal transduction regulation of cardiac muscle contraction by calcium ion signaling regulation of cardiac muscle contraction regulation of blood circulation regulation of striated muscle contraction calcium-mediated signaling	striated muscle thin filament protein-containing complex intracellular anatomical structure myofilament intracellular membraneless organelle actin cytoskeleton sarcomere intracellular organelle cellular anatomical structure troponin complex cytoskeleton organelle membraneless organelle contractile muscle fiber striated muscle thin filament protein-containing complex intracellular anatomical structure myofilament intracellular membraneless organelle actin cytoskeleton sarcomere intracellular organelle cellular anatomical structure troponin complex cytoskeleton organelle membraneless organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex cytosol cardiac myofibril cardiac Troponin complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth C]	IPR050230	Calmodulin/Myosin light chain/Troponin C-like	Family
A [auth C]	IPR018247	EF-Hand 1, calcium-binding site	Binding Site
A [auth C]	IPR002048	EF-hand domain	Domain
A [auth C]	IPR011992	EF-hand domain pair	Homologous Superfamily
B [auth I]	IPR001978	Troponin	Family
B [auth I]	IPR050875	Troponin I	Family
B [auth I]	IPR038077	Troponin domain superfamily	Homologous Superfamily
B [auth I]	IPR021666	Troponin I residues 1-32	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth C]	Pharos: P63316	dilated cardiomyopathy 1Z hypertrophic cardiomyopathy 13 dilated cardiomyopathy cardiomyopathy pituitary cancer congestive heart failure endometriosis Hodgkins lymphoma interstitial cystitis lung carcinoma mood disorder psoriasis Charcot-Marie-Tooth disease familial dilated cardiomyopathy hypertrophic cardiomyopathy dilated cardiomyopathy 1Z hypertrophic cardiomyopathy 13 dilated cardiomyopathy cardiomyopathy pituitary cancer congestive heart failure endometriosis Hodgkins lymphoma interstitial cystitis lung carcinoma mood disorder psoriasis Charcot-Marie-Tooth disease familial dilated cardiomyopathy hypertrophic cardiomyopathy lung adenocarcinoma malignant colon neoplasm non-small cell lung carcinoma Conduction disorder of the heart familial isolated dilated cardiomyopathy lung cancer malignant mesothelioma
B [auth I]	Pharos: P19429	dilated cardiomyopathy cardiomyopathy hypertrophic cardiomyopathy 7 cardiomyopathy, familial restrictive, 1 restrictive cardiomyopathy dilated cardiomyopathy 1FF dilated cardiomyopathy 2A hypertrophic cardiomyopathy heart disease acute coronary syndrome myocardial infarction medulloblastoma Obstructive asymmetric septal hypertrophy systemic lupus erythematosus Charcot-Marie-Tooth disease dilated cardiomyopathy cardiomyopathy hypertrophic cardiomyopathy 7 cardiomyopathy, familial restrictive, 1 restrictive cardiomyopathy dilated cardiomyopathy 1FF dilated cardiomyopathy 2A hypertrophic cardiomyopathy heart disease acute coronary syndrome myocardial infarction medulloblastoma Obstructive asymmetric septal hypertrophy systemic lupus erythematosus Charcot-Marie-Tooth disease familial hypertrophic cardiomyopathy hypertensive disorder dilated cardiomyopathy 1A facioscapulohumeral muscular dystrophy familial isolated dilated cardiomyopathy left ventricular noncompaction coronary artery disease familial dilated cardiomyopathy

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.