Annotations: 1N7E

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1n7ea_	All beta proteins	PDZ domain-like	PDZ domain-like	PDZ domain	Glutamate receptor-interacting protein 1, GRIP1	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	PDZ domain	8024317	4001790	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	PDZ domain-like	8036696	3000388	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PDZ	e1n7eA1	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PDZ	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00595	PDZ domain (PDZ)	PDZ domain	PDZ domains are found in diverse signaling proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	AMPA receptor interacting protein GRIP	protein binding binding signaling receptor binding PDZ domain binding protein domain specific binding ionotropic glutamate receptor binding glutamate receptor binding enzyme binding GTPase binding	multicellular organismal process cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis cellular component organization neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis dendrite development cell differentiation multicellular organismal process cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis cellular component organization neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis dendrite development cell differentiation anatomical structure development cellular component organization or biogenesis system development developmental process plasma membrane bounded cell projection organization dendrite arborization dendrite morphogenesis nervous system development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron projection arborization neuron development cellular process regulation of synaptic plasticity trans-synaptic signaling regulation of biological process regulation of signaling regulation of cellular process modulation of chemical synaptic transmission signaling biological regulation cell-cell signaling chemical synaptic transmission cell communication regulation of synaptic scaling synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of cell communication regulation of biological quality protein localization localization cellular localization cellular macromolecule localization macromolecule localization cellular response to endogenous stimulus cellular response to growth factor stimulus response to stimulus response to endogenous stimulus cellular response to nerve growth factor stimulus cellular response to brain-derived neurotrophic factor stimulus response to nerve growth factor response to growth factor positive regulation of protein localization to plasma membrane regulation of localization regulation of protein localization positive regulation of biological process regulation of protein localization to membrane positive regulation of cellular process positive regulation of protein localization to cell periphery protein localization to cell periphery protein localization to plasma membrane positive regulation of protein localization to membrane localization within membrane regulation of protein localization to cell periphery protein localization to membrane regulation of cellular localization positive regulation of protein localization regulation of protein localization to plasma membrane cellular response to stimulus response to ketone response to lipid response to alcohol response to oxygen-containing compound cellular response to oxygen-containing compound cellular response to chemical stimulus response to phorbol 13-acetate 12-myristate cellular response to alcohol response to chemical cellular response to phorbol 13-acetate 12-myristate cellular response to lipid cellular response to ketone transport establishment of localization vesicle-mediated transport vesicle-mediated transport in synapse head development forebrain development animal organ development brain development pallium development cerebral cortex development central nervous system development telencephalon development regulation of cellular component organization positive regulation of cellular component organization regulation of developmental process regulation of neuron projection arborization regulation of cell morphogenesis positive regulation of developmental process positive regulation of cell projection organization regulation of anatomical structure morphogenesis regulation of cell projection organization positive regulation of neuron projection arborization positive regulation of nervous system development regulation of cell differentiation regulation of neurogenesis regulation of cell development regulation of dendrite morphogenesis positive regulation of cell development positive regulation of cell morphogenesis regulation of dendrite development positive regulation of multicellular organismal process regulation of neuron projection development regulation of nervous system development positive regulation of cell differentiation positive regulation of neurogenesis regulation of multicellular organismal process regulation of multicellular organismal development positive regulation of dendrite morphogenesis regulation of plasma membrane bounded cell projection organization establishment of protein localization nitrogen compound transport protein localization to synapse neurotransmitter receptor transport to postsynaptic membrane establishment of protein localization to plasma membrane establishment of protein localization to postsynaptic membrane endocytic recycling neurotransmitter receptor transport to plasma membrane neurotransmitter receptor transport, endosome to plasma membrane establishment of localization in cell neurotransmitter receptor transport, endosome to postsynaptic membrane protein localization to postsynaptic membrane neurotransmitter receptor transport establishment of protein localization to membrane intracellular transport protein-containing complex localization endosomal transport vesicle-mediated transport to the plasma membrane endosome to plasma membrane protein transport regulation of postsynaptic membrane neurotransmitter receptor levels protein transport protein localization to postsynapse protein localization to cell junction receptor localization to synapse intracellular protein transport	cell periphery postsynapse cellular anatomical structure postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region synaptic membrane somatodendritic compartment cell body perikaryon neuronal cell body cell periphery postsynapse cellular anatomical structure postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region synaptic membrane somatodendritic compartment cell body perikaryon neuronal cell body presynapse presynaptic active zone axon neuron projection axon terminus plasma membrane bounded cell projection cell projection distal axon terminal bouton neuron projection terminus proximal dendrite dendrite dendritic tree neuron spine dendritic spine head dendritic spine presynaptic membrane synaptic cleft extracellular region membrane microdomain membrane raft protein-containing complex cell cortex intracellular anatomical structure exocyst cytoplasm vesicle tethering complex GABA-ergic synapse glutamatergic synapse membrane-bounded organelle organelle subcompartment intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum organelle membrane endoplasmic reticulum membrane endosome intracellular vesicle recycling endosome cytoplasmic vesicle vesicle spine synapse neuron to neuron synapse asymmetric synapse dendritic shaft postsynaptic density postsynaptic specialization perinuclear region of cytoplasm dendritic spine neck polymeric cytoskeletal fiber intracellular membraneless organelle cytoskeleton membraneless organelle supramolecular fiber microtubule supramolecular polymer supramolecular complex microtubule cytoskeleton

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR043545	Glutamate receptor-interacting protein 1/2	Family
A	IPR041489	PDZ domain 6	Domain
A	IPR036034	PDZ superfamily	Homologous Superfamily
A	IPR001478	PDZ domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.