1OA2 | pdb_00001oa2

Comparison of Family 12 Glycoside Hydrolases and Recruited Substitutions Important for Thermal Stability

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Protein Modification Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1oa2a_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	Xylanase/endoglucanase 11/12	Family 12 endo-1,4-beta-glucanase (cellulase) catalytic domain	(Trichoderma reesei ) [TaxId: 51453 ],	SCOPe (2.08)
B	d1oa2b_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	Xylanase/endoglucanase 11/12	Family 12 endo-1,4-beta-glucanase (cellulase) catalytic domain	(Trichoderma reesei ) [TaxId: 51453 ],	SCOPe (2.08)
C	d1oa2c_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	Xylanase/endoglucanase 11/12	Family 12 endo-1,4-beta-glucanase (cellulase) catalytic domain	(Trichoderma reesei ) [TaxId: 51453 ],	SCOPe (2.08)
D	d1oa2d_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	Xylanase/endoglucanase 11/12	Family 12 endo-1,4-beta-glucanase (cellulase) catalytic domain	(Trichoderma reesei ) [TaxId: 51453 ],	SCOPe (2.08)
E	d1oa2e_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	Xylanase/endoglucanase 11/12	Family 12 endo-1,4-beta-glucanase (cellulase) catalytic domain	(Trichoderma reesei ) [TaxId: 51453 ],	SCOPe (2.08)
F	d1oa2f_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	Xylanase/endoglucanase 11/12	Family 12 endo-1,4-beta-glucanase (cellulase) catalytic domain	(Trichoderma reesei ) [TaxId: 51453 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8033036	3000120	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8033036	3000120	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8033036	3000120	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8033036	3000120	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8033036	3000120	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8033036	3000120	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Glyco_hydro_12	e1oa2A1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Glyco_hydro_12	ECOD (1.6)
B	Glyco_hydro_12	e1oa2B1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Glyco_hydro_12	ECOD (1.6)
C	Glyco_hydro_12	e1oa2C1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Glyco_hydro_12	ECOD (1.6)
D	Glyco_hydro_12	e1oa2D1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Glyco_hydro_12	ECOD (1.6)
E	Glyco_hydro_12	e1oa2E1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Glyco_hydro_12	ECOD (1.6)
F	Glyco_hydro_12	e1oa2F1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Glyco_hydro_12	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.120.180	Mainly Beta	Sandwich	Jelly Rolls	Glycoside hydrolase family 11/12, catalytic domain	CATH (4.3.0)
B	2.60.120.180	Mainly Beta	Sandwich	Jelly Rolls	Glycoside hydrolase family 11/12, catalytic domain	CATH (4.3.0)
C	2.60.120.180	Mainly Beta	Sandwich	Jelly Rolls	Glycoside hydrolase family 11/12, catalytic domain	CATH (4.3.0)
D	2.60.120.180	Mainly Beta	Sandwich	Jelly Rolls	Glycoside hydrolase family 11/12, catalytic domain	CATH (4.3.0)
E	2.60.120.180	Mainly Beta	Sandwich	Jelly Rolls	Glycoside hydrolase family 11/12, catalytic domain	CATH (4.3.0)
F	2.60.120.180	Mainly Beta	Sandwich	Jelly Rolls	Glycoside hydrolase family 11/12, catalytic domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF01670	Glycosyl hydrolase family 12 (Glyco_hydro_12)	Glycosyl hydrolase family 12		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	ENDO-BETA-1,4-GLUCANASE	hydrolase activity, acting on glycosyl bonds cellulase activity hydrolase activity, hydrolyzing O-glycosyl compounds hydrolase activity catalytic activity	carbohydrate metabolic process polysaccharide metabolic process catabolic process polysaccharide catabolic process carbohydrate catabolic process metabolic process cellular process primary metabolic process macromolecule metabolic process macromolecule catabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR013319	Glycoside hydrolase family 11/12	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR002594	Glycoside hydrolase family 12	Family

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A, B, C, D, E A, B, C, D, E, F	PCA	Parent Component: GLN RESID: AA0031 PSI-MOD : 2-pyrrolidone-5-carboxylic acid (Gln) MOD:00040 , 2-pyrrolidone-5-carboxylic acid (Glu) MOD:00420

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.