1TAZ

Catalytic Domain Of Human Phosphodiesterase 1B

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1taza_	All alpha proteins	HD-domain/PDEase-like	HD-domain/PDEase-like	PDEase	Catalytic domain of cyclic nucleotide phosphodiesterase 1b, PDE1B	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	PDEase-like	8027736	4001423	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	HD-domain/PDEase-like	8040115	3000943	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PDEase_I	e1tazA1	A: alpha complex topology	X: PDEase-like	H: HD-domain/PDEase-like (From Topology)	T: HD-domain/PDEase-like	F: PDEase_I	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.1300.10	Mainly Alpha	Orthogonal Bundle	Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00233	3'5'-cyclic nucleotide phosphodiesterase (PDEase_I)	3'5'-cyclic nucleotide phosphodiesterase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	phosphoric ester hydrolase activity hydrolase activity, acting on ester bonds phosphoric diester hydrolase activity 3',5'-cyclic-nucleotide phosphodiesterase activity hydrolase activity cyclic-nucleotide phosphodiesterase activity catalytic activity 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity 3',5'-cyclic-GMP phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity 3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity protein binding binding phosphoric ester hydrolase activity hydrolase activity, acting on ester bonds phosphoric diester hydrolase activity 3',5'-cyclic-nucleotide phosphodiesterase activity hydrolase activity cyclic-nucleotide phosphodiesterase activity catalytic activity 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity 3',5'-cyclic-GMP phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity 3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity protein binding binding calmodulin binding calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity cation binding ion binding metal ion binding small molecule binding	behavior multicellular organismal process locomotory behavior response to peptide response to stimulus response to chemical response to cytokine cellular response to cytokine stimulus response to macrophage colony-stimulating factor cellular response to macrophage colony-stimulating factor stimulus response to light stimulus system process learning learning or memory behavior multicellular organismal process locomotory behavior response to peptide response to stimulus response to chemical response to cytokine cellular response to cytokine stimulus response to macrophage colony-stimulating factor cellular response to macrophage colony-stimulating factor stimulus response to light stimulus system process learning learning or memory nervous system process visual learning visual behavior cognition associative learning response to radiation response to abiotic stimulus ammonium ion metabolic process serotonin metabolic process phenol-containing compound metabolic process organic hydroxy compound metabolic process indole-containing compound metabolic process metabolic process cellular process primary amino compound metabolic process response to granulocyte macrophage colony-stimulating factor cellular response to granulocyte macrophage colony-stimulating factor stimulus developmental process myeloid leukocyte differentiation cellular developmental process hemopoiesis cell development mononuclear cell differentiation myeloid cell differentiation cell differentiation anatomical structure development monocyte differentiation leukocyte differentiation response to amine response to nitrogen compound response to amphetamine cellular response to stimulus regulation of biological process regulation of cellular process signaling biological regulation intracellular signal transduction cell communication cAMP-mediated signaling intracellular signaling cassette signal transduction catecholamine catabolic process catabolic process catechol-containing compound catabolic process dopamine metabolic process catechol-containing compound metabolic process biogenic amine catabolic process phenol-containing compound catabolic process amine metabolic process dopamine catabolic process catecholamine metabolic process organic hydroxy compound catabolic process biogenic amine metabolic process amine catabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol somatodendritic compartment cell body neuronal cell body

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036971	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily	Homologous Superfamily
A	IPR023174	3'5'-cyclic nucleotide phosphodiesterase, conserved site	Conserved Site
A	IPR013706	3'5'-cyclic nucleotide phosphodiesterase N-terminal	Domain
A	IPR003607	HD/PDEase domain	Domain
A	IPR002073	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain	Domain
A	IPR023088	3'5'-cyclic nucleotide phosphodiesterase	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q01064	Adult Learning Disorders depressive disorder learning disability MALT lymphoma atrial fibrillation

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.