1Z9Q | pdb_00001z9q

Solution structure of SH3 domain of p40phox

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1z9qa_	All beta proteins	SH3-like barrel	SH3-domain	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	SH3-domain	8062117	3000153	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	SH3_1	e1z9qA1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: SH3_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.30.40	Mainly Beta	Roll	SH3 type barrels.	SH3 Domains	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00018	SH3 domain (SH3_1)	SH3 domain	SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organisation. First described in the Src cytoplasmic tyrosine kinase Swiss:P12931. The structure is a partly opened beta barrel.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Neutrophil cytosol factor 4	enzyme regulator activity molecular function activator activity oxidoreductase activity, acting on NAD(P)H oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor superoxide-generating NADPH oxidase activator activity oxidoreductase activity enzyme activator activity superoxide-generating NADPH oxidase activity superoxide-generating NAD(P)H oxidase activity molecular function regulator activity catalytic activity binding phospholipid binding lipid binding enzyme regulator activity molecular function activator activity oxidoreductase activity, acting on NAD(P)H oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor superoxide-generating NADPH oxidase activator activity oxidoreductase activity enzyme activator activity superoxide-generating NADPH oxidase activity superoxide-generating NAD(P)H oxidase activity molecular function regulator activity catalytic activity binding phospholipid binding lipid binding phosphatidylinositol-3-phosphate binding phosphatidylinositol phosphate binding phosphatidylinositol binding	superoxide metabolic process superoxide anion generation reactive oxygen species metabolic process metabolic process cellular process localization import into cell transport phagocytosis endocytosis establishment of localization vesicle-mediated transport respiratory burst	cellular anatomical structure membrane membrane-bounded organelle phagolysosome intracellular anatomical structure lytic vacuole intracellular vesicle vacuole phagocytic vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle organelle secondary lysosome cellular anatomical structure membrane membrane-bounded organelle phagolysosome intracellular anatomical structure lytic vacuole intracellular vesicle vacuole phagocytic vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle organelle secondary lysosome cytoplasm vesicle endocytic vesicle lysosome cytosol endosome membrane endosome endomembrane system cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane organelle membrane cell periphery plasma membrane protein-containing complex catalytic complex plasma membrane protein complex NADPH oxidase complex membrane protein complex oxidoreductase complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000919	Neutrophil cytosol factor P40	Family
A	IPR034912	Neutrophil cytosol factor 4, PX domain	Domain
A	IPR051228	NADPH Oxidase and PX Domain-Containing	Family
A	IPR001683	Phox homology	Domain
A	IPR000270	PB1 domain	Domain
A	IPR053793	PB1-like domain	Domain
A	IPR036871	PX domain superfamily	Homologous Superfamily
A	IPR001452	SH3 domain	Domain
A	IPR034853	Neutrophil cytosol factor P40, PB1 domain	Domain
A	IPR035541	Neutrophil cytosol factor P40, SH3 domain	Domain
A	IPR036028	SH3-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q15080	chronic granulomatous disease Crohn disease granulomatous disease, chronic, autosomal recessive, cytochrome b-positive, type 3 heart disease periodontitis Regional enteritis acute myeloid leukemia glioblastoma ileocolitis lung cancer non-small cell lung carcinoma phagocyte bactericidal dysfunction tuberculosis adrenal cortex carcinoma interstitial cystitis chronic granulomatous disease Crohn disease granulomatous disease, chronic, autosomal recessive, cytochrome b-positive, type 3 heart disease periodontitis Regional enteritis acute myeloid leukemia glioblastoma ileocolitis lung cancer non-small cell lung carcinoma phagocyte bactericidal dysfunction tuberculosis adrenal cortex carcinoma interstitial cystitis lung carcinoma osteosarcoma pilocytic astrocytoma ulcerative colitis allergic rhinitis Crohn's colitis cutaneous lupus erythematosus invasive ductal breast carcinoma malignant glioma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.