2VQT
Structural and biochemical evidence for a boat-like transition state in beta-mannosidases
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A | SCOP2B Superfamily | beta-Galactosidase/glucuronidase domain-like | 8055217 | 3002047 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | (Trans)glycosidases | 8034628 | 3000313 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | beta-Galactosidase/glucuronidase domain-like | 8055472 | 3002047 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | beta-Galactosidase/glucuronidase domain-like | 8055470 | 3002047 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | galactose-binding domain-like | 8034627 | 3000087 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | beta-Galactosidase/glucuronidase domain-like | 8055217 | 3002047 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | beta-Galactosidase/glucuronidase domain-like | 8055470 | 3002047 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | beta-Galactosidase/glucuronidase domain-like | 8055472 | 3002047 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | (Trans)glycosidases | 8034628 | 3000313 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | galactose-binding domain-like | 8034627 | 3000087 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | Glyco_hydro_2_N | e2vqtA1 | A: beta sandwiches | X: jelly-roll | H: Concanavalin A-like | T: Galactose-binding domain-like | F: Glyco_hydro_2_N | ECOD (1.6) |
A | Glyco_hydro_2 | e2vqtA2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: Glyco_hydro_2 | ECOD (1.6) |
A | EUF07702 | e2vqtA4 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: EUF07702 | ECOD (1.6) |
A | EUF07703 | e2vqtA3 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: EUF07703 | ECOD (1.6) |
A | Glyco_hydro_2_C | e2vqtA5 | A: a/b barrels | X: TIM beta/alpha-barrel | H: TIM barrels (From Topology) | T: TIM barrels | F: Glyco_hydro_2_C | ECOD (1.6) |
B | Glyco_hydro_2_N | e2vqtB1 | A: beta sandwiches | X: jelly-roll | H: Concanavalin A-like | T: Galactose-binding domain-like | F: Glyco_hydro_2_N | ECOD (1.6) |
B | Glyco_hydro_2 | e2vqtB2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: Glyco_hydro_2 | ECOD (1.6) |
B | EUF07702 | e2vqtB4 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: EUF07702 | ECOD (1.6) |
B | EUF07703 | e2vqtB3 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: EUF07703 | ECOD (1.6) |
B | Glyco_hydro_2_C | e2vqtB5 | A: a/b barrels | X: TIM beta/alpha-barrel | H: TIM barrels (From Topology) | T: TIM barrels | F: Glyco_hydro_2_C | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 2.60.120.260 | Mainly Beta | Sandwich | Jelly Rolls | Galactose-binding domain-like | CATH (4.3.0) |
A | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (4.3.0) |
A | 3.20.20.80 | Alpha Beta | Alpha-Beta Barrel | TIM Barrel | Glycosidases | CATH (4.3.0) |
B | 2.60.120.260 | Mainly Beta | Sandwich | Jelly Rolls | Galactose-binding domain-like | CATH (4.3.0) |
B | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (4.3.0) |
B | 3.20.20.80 | Alpha Beta | Alpha-Beta Barrel | TIM Barrel | Glycosidases | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF00703 | Glycosyl hydrolases family 2 (Glyco_hydro_2) | Glycosyl hydrolases family 2 | This family contains beta-galactosidase, beta-mannosidase and beta-glucuronidase activities. | Domain | |
PF17753 | Ig-fold domain (Ig_mannosidase) | Ig-fold domain | This Ig-like fold domain is found in mannosidase enzymes [1]. | Domain | |
PF17786 | Mannosidase Ig/CBM-like domain (Mannosidase_ig) | Mannosidase Ig/CBM-like domain | This domain corresponds to domain 4 in the structure of Bacteroides thetaiotaomicron beta-mannosidase, BtMan2A [1]. This domain has an Ig-like fold. | Domain | |
PF22666 | Glycosyl hydrolase 2 galactose-binding domain-like (Glyco_hydro_2_N2) | Glycosyl hydrolase 2 galactose-binding domain-like | This domain is found in a number of proteins belonging to glycosyl hydrolase 2 family [1-5]. | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR017853 | Glycoside hydrolase superfamily | Homologous Superfamily | |
IPR008979 | Galactose-binding-like domain superfamily | Homologous Superfamily | |
IPR006102 | Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich | Domain | |
IPR036156 | Beta-Galactosidase/glucuronidase domain superfamily | Homologous Superfamily | |
IPR050887 | Beta-mannosidase glycosyl hydrolases | Family | |
IPR041447 | Mannosidase Ig/CBM-like domain | Domain | |
IPR013783 | Immunoglobulin-like fold | Homologous Superfamily | |
IPR041625 | Beta-mannosidase, Ig-fold domain | Domain | |
IPR054593 | Beta-mannosidase-like, galactose-binding domain-like | Domain |