Annotations: 2DL1

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	MIT	e2dl1A1	A: alpha bundles	X: Spectrin repeat-like	H: MIT domain (From Topology)	T: MIT domain	F: MIT	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.58.80	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Spartin	binding lipid binding ubiquitin protein ligase binding protein binding ubiquitin-like protein ligase binding enzyme binding	developmental process connective tissue development adipose tissue development animal organ development anatomical structure development tissue development cellular response to stimulus cellular response to BMP stimulus regulation of biological process cell surface receptor protein serine/threonine kinase signaling pathway regulation of cellular process cellular response to growth factor stimulus cell surface receptor signaling pathway response to stimulus developmental process connective tissue development adipose tissue development animal organ development anatomical structure development tissue development cellular response to stimulus cellular response to BMP stimulus regulation of biological process cell surface receptor protein serine/threonine kinase signaling pathway regulation of cellular process cellular response to growth factor stimulus cell surface receptor signaling pathway response to stimulus signaling response to endogenous stimulus biological regulation cell communication cellular response to endogenous stimulus response to BMP cellular process transforming growth factor beta receptor superfamily signaling pathway signal transduction response to growth factor BMP signaling pathway enzyme-linked receptor protein signaling pathway cell division regulation of mitochondrial membrane potential regulation of biological quality regulation of membrane potential localization transport macromolecule localization lipid localization lipid transport establishment of localization membrane organization cytoskeleton-dependent cytokinesis mitotic cytokinetic process mitotic cytokinesis cytokinesis mitotic cell cycle cellular component organization mitotic cell cycle process midbody abscission cytokinetic process cellular component organization or biogenesis cell cycle cell cycle process multicellular organismal process regulation of growth axonogenesis regulation of cellular component size cell projection organization developmental growth negative regulation of biological process regulation of cell differentiation regulation of neurogenesis neuron projection development regulation of cell development multicellular organism development collateral sprouting in absence of injury cell projection morphogenesis neuron differentiation negative regulation of growth neuron projection morphogenesis cell differentiation system development negative regulation of cellular component organization regulation of collateral sprouting in absence of injury regulation of cell projection organization negative regulation of cell growth nervous system development developmental growth involved in morphogenesis generation of neurons negative regulation of axonogenesis negative regulation of developmental growth negative regulation of multicellular organismal process regulation of neuron projection development regulation of collateral sprouting regulation of cellular component organization cellular developmental process regulation of developmental process plasma membrane bounded cell projection morphogenesis cell development cell growth cell morphogenesis regulation of nervous system development neurogenesis negative regulation of neurogenesis regulation of extent of cell growth regulation of axonogenesis negative regulation of collateral sprouting in absence of injury negative regulation of cellular process negative regulation of nervous system development regulation of multicellular organismal process negative regulation of cell differentiation negative regulation of cell projection organization regulation of anatomical structure morphogenesis regulation of cell size regulation of multicellular organismal development collateral sprouting regulation of developmental growth plasma membrane bounded cell projection organization developmental cell growth negative regulation of developmental process growth axon development regulation of cell growth cell morphogenesis involved in neuron differentiation negative regulation of neuron projection development anatomical structure morphogenesis negative regulation of cell development neuron development negative regulation of collateral sprouting regulation of plasma membrane bounded cell projection organization regulation of anatomical structure size negative regulation of signaling regulation of transmembrane receptor protein serine/threonine kinase signaling pathway regulation of signal transduction negative regulation of cellular response to growth factor stimulus negative regulation of BMP signaling pathway negative regulation of cell communication regulation of signaling regulation of BMP signaling pathway negative regulation of response to stimulus regulation of cellular response to growth factor stimulus negative regulation of signal transduction regulation of response to stimulus regulation of cell communication negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway system process nervous system process neuromuscular process lipid catabolic process catabolic process metabolic process primary metabolic process lipid metabolic process organelle organization lipid droplet organization lipophagy macroautophagy autophagy process utilizing autophagic mechanism	midbody cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane membrane-bounded organelle intracellular organelle organelle intracellular membrane-bounded organelle lipid droplet membraneless organelle midbody cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane membrane-bounded organelle intracellular organelle organelle intracellular membrane-bounded organelle lipid droplet membraneless organelle intracellular membraneless organelle synapse cell junction mitochondrial membrane mitochondrion organelle outer membrane organelle envelope bounding membrane of organelle mitochondrial envelope mitochondrial outer membrane outer membrane organelle membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR009686	Senescence/spartin-associated, C-terminal	Domain
A	IPR007330	MIT domain	Domain
A	IPR036181	MIT domain superfamily	Homologous Superfamily
A	IPR045036	Spartin-like	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q8N0X7	Troyer syndrome esophageal adenocarcinoma hereditary spastic paraplegia paraplegia Spastic Paraplegia, Hereditary ulcerative colitis adrenal cortex carcinoma Crohn disease leukodystrophy malignant ependymoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia strabismus breast cancer ductal breast carcinoma in situ Troyer syndrome esophageal adenocarcinoma hereditary spastic paraplegia paraplegia Spastic Paraplegia, Hereditary ulcerative colitis adrenal cortex carcinoma Crohn disease leukodystrophy malignant ependymoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia strabismus breast cancer ductal breast carcinoma in situ intellectual disability lung cancer neurodegenerative disease pancreatic intraductal papillary-mucinous carcinoma Charcot-Marie-Tooth disease invasive ductal breast carcinoma lung carcinoma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.