2KSF | pdb_00002ksf

Backbone structure of the membrane domain of E. coli histidine kinase receptor KdpD, Center for Structures of Membrane Proteins (CSMP) target 4312C

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	DUF4118	e2ksfA1	A: alpha bundles	X: Four-helical up-and-down bundle	H: Histidine kinase receptor KdpD transmembrane domain (From Topology)	T: Histidine kinase receptor KdpD transmembrane domain	F: DUF4118	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.120.620	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	Backbone structure of the membrane domain of e. Coli histidine kinase receptor kdpd,	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF13493	Domain of unknown function (DUF4118) (DUF4118)	Domain of unknown function (DUF4118)	This domain is found in a wide variety of bacterial signalling proteins. It is likely to be a transmembrane domain involved in ligand sensing.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Sensor protein kdpD	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding transferase activity catalytic activity transferase activity, transferring phosphorus-containing groups identical protein binding protein binding protein homodimerization activity protein dimerization activity molecular sensor activity catalytic activity, acting on a protein kinase activity protein kinase activity phosphotransferase activity, nitrogenous group as acceptor phosphotransferase activity, alcohol group as acceptor protein histidine kinase activity phosphorelay sensor kinase activity molecular function regulator activity	cellular response to stimulus cellular response to metal ion cellular response to chemical stimulus response to stimulus response to metal ion response to potassium ion response to chemical cellular process cellular response to potassium ion regulation of biological process regulation of cellular process signaling biological regulation signal transduction cellular response to stimulus cellular response to metal ion cellular response to chemical stimulus response to stimulus response to metal ion response to potassium ion response to chemical cellular process cellular response to potassium ion regulation of biological process regulation of cellular process signaling biological regulation signal transduction cell communication	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane outer membrane-bounded periplasmic space cell envelope periplasmic space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR004358	Signal transduction histidine kinase-related protein, C-terminal	Domain
A	IPR003852	Signal transduction histidine kinase, osmosensitive K+ channel sensor, N-terminal	Domain
A	IPR036097	Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily	Homologous Superfamily
A	IPR025201	Sensor protein KdpD, transmembrane domain	Domain
A	IPR036890	Histidine kinase/HSP90-like ATPase superfamily	Homologous Superfamily
A	IPR003661	Signal transduction histidine kinase, dimerisation/phosphoacceptor domain	Domain
A	IPR003594	Histidine kinase/HSP90-like ATPase domain	Domain
A	IPR005467	Histidine kinase domain	Domain
A	IPR003018	GAF domain	Domain
A	IPR029016	GAF-like domain superfamily	Homologous Superfamily
A	IPR052023	Sensor histidine kinase KdpD	Family
A	IPR038318	KdpD, transmembrane domain superfamily	Homologous Superfamily
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A	OPM				Signal transduction histidine kinase

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Histidine Kinase Receptors	KdpD (397-502) Sensor protein membrane domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.