2L87 | pdb_00002l87

The 27-residue N-terminus CCR5-peptide in a ternary complex with HIV-1 gp120 and a CD4-mimic peptide

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	C-C chemokine receptor type 5	protein binding binding virus receptor activity exogenous protein binding molecular transducer activity coreceptor activity signaling receptor activity phosphoric ester hydrolase activity hydrolase activity, acting on ester bonds phosphoric diester hydrolase activity phospholipase C activity hydrolase activity phosphatidylinositol-4,5-bisphosphate phospholipase C activity catalytic activity protein binding binding virus receptor activity exogenous protein binding molecular transducer activity coreceptor activity signaling receptor activity phosphoric ester hydrolase activity hydrolase activity, acting on ester bonds phosphoric diester hydrolase activity phospholipase C activity hydrolase activity phosphatidylinositol-4,5-bisphosphate phospholipase C activity catalytic activity phospholipase activity lipase activity G protein-coupled chemoattractant receptor activity C-C chemokine receptor activity chemokine receptor activity G protein-coupled receptor activity transmembrane signaling receptor activity cytokine receptor activity immune receptor activity cytoskeletal protein binding actin binding C-C chemokine binding chemokine binding cytokine binding chemokine (C-C motif) ligand 5 binding identical protein binding	regulation of cellular process leukocyte apoptotic process negative regulation of biological process regulation of programmed cell death macrophage apoptotic process negative regulation of leukocyte apoptotic process negative regulation of cellular process myeloid cell apoptotic process regulation of leukocyte apoptotic process regulation of biological process negative regulation of programmed cell death regulation of apoptotic process biological regulation negative regulation of macrophage apoptotic process regulation of cellular process leukocyte apoptotic process negative regulation of biological process regulation of programmed cell death macrophage apoptotic process negative regulation of leukocyte apoptotic process negative regulation of cellular process myeloid cell apoptotic process regulation of leukocyte apoptotic process regulation of biological process negative regulation of programmed cell death regulation of apoptotic process biological regulation negative regulation of macrophage apoptotic process cell death negative regulation of apoptotic process regulation of macrophage apoptotic process inflammatory cell apoptotic process cellular process negative regulation of myeloid cell apoptotic process apoptotic process regulation of myeloid cell apoptotic process programmed cell death positive regulation of cytosolic calcium ion concentration regulation of biological quality response to stimulus immune response immune system process response to sterol response to lipid response to alcohol response to chemical response to oxygen-containing compound response to cholesterol signaling cell-cell signaling cell communication cellular response to stimulus biological process involved in interspecies interaction between organisms response to other organism cellular response to lipopolysaccharide response to external stimulus cellular response to molecule of bacterial origin response to lipopolysaccharide cellular response to oxygen-containing compound response to biotic stimulus cellular response to biotic stimulus cellular response to chemical stimulus response to bacterium cellular response to lipid response to external biotic stimulus response to molecule of bacterial origin intracellular signal transduction calcium-mediated signaling intracellular signaling cassette signal transduction MAPK cascade chemotaxis taxis locomotion cell chemotaxis dendritic cell chemotaxis leukocyte migration dendritic cell migration mononuclear cell migration cell migration cell motility leukocyte chemotaxis cell surface receptor signaling pathway defense response response to stress cellular defense response localization transport monoatomic ion transport monoatomic cation transport establishment of localization calcium ion transport metal ion transport inflammatory response G protein-coupled receptor signaling pathway regulation of localization cellular localization inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process monoatomic ion transmembrane transport sarcoplasmic reticulum calcium ion transport calcium ion homeostasis release of sequestered calcium ion into cytosol by sarcoplasmic reticulum negative regulation of sequestering of calcium ion maintenance of location in cell monoatomic cation transmembrane transport intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis regulation of sequestering of calcium ion intracellular monoatomic ion homeostasis release of sequestered calcium ion into cytosol by endoplasmic reticulum calcium ion transmembrane import into cytosol sequestering of calcium ion inorganic ion transmembrane transport inorganic cation transmembrane transport maintenance of location transmembrane transport release of sequestered calcium ion into cytosol cellular homeostasis chemical homeostasis calcium ion transmembrane transport	cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane intracellular anatomical structure cytoplasm membrane-bounded organelle endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane intracellular anatomical structure cytoplasm membrane-bounded organelle endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle vesicle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000276	G protein-coupled receptor, rhodopsin-like	Family
A	IPR017452	GPCR, rhodopsin-like, 7TM	Domain
A	IPR000355	Chemokine receptor family	Family
A	IPR050119	C-C chemokine receptor type 1-9-like	Family
A	IPR002240	CC chemokine receptor 5	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P51681	hepatitis C virus infection type 1 diabetes mellitus 22 nephritis West Nile fever inflammatory bowel disease Kidney Failure, Acute acquired metabolic disease psoriasis schizophrenia autoimmune disease tuberculosis celiac disease ulcerative colitis dermatitis, atopic glioblastoma hepatitis C virus infection type 1 diabetes mellitus 22 nephritis West Nile fever inflammatory bowel disease Kidney Failure, Acute acquired metabolic disease psoriasis schizophrenia autoimmune disease tuberculosis celiac disease ulcerative colitis dermatitis, atopic glioblastoma hepatocellular carcinoma interstitial cystitis lung cancer osteosarcoma acute kidney failure rheumatoid arthritis AIDS Sjogren syndrome cancer type 1 diabetes mellitus chronic obstructive pulmonary disease diabetes mellitus head and neck cancer IgA glomerulonephritis invasive ductal breast carcinoma malignant glioma pilocytic astrocytoma sarcoidosis atopic eczema subependymal giant cell astrocytoma cutaneous lupus erythematosus ductal breast carcinoma in situ West-Nile encephalitis

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A	TYS	Parent Component: TYR RESID: AA0172 PSI-MOD : O4'-sulfo-L-tyrosine MOD:00181

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.