2MC1 | pdb_00002mc1

Solution structure of the Vav1 SH2 domain complexed with a Syk-derived singly phosphorylated peptide

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	SH2 domain	8057885	3000197	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	SH2	e2mc1A1	A: a+b two layers	X: SH2 (From Topology)	H: SH2 (From Topology)	T: SH2	F: SH2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.505.10	Alpha Beta	2-Layer Sandwich	SHC Adaptor Protein	SH2 domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00017	SH2 domain (SH2)	SH2 domain		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Proto-oncogene vav	phosphoprotein binding phosphotyrosine residue binding protein binding binding protein phosphorylated amino acid binding enzyme regulator activity guanyl nucleotide binding GTP binding nucleotide binding hydrolase activity guanyl ribonucleotide binding GDP binding purine ribonucleotide binding ion binding phosphoprotein binding phosphotyrosine residue binding protein binding binding protein phosphorylated amino acid binding enzyme regulator activity guanyl nucleotide binding GTP binding nucleotide binding hydrolase activity guanyl ribonucleotide binding GDP binding purine ribonucleotide binding ion binding ribonucleoside triphosphate phosphatase activity anion binding molecular function regulator activity heterocyclic compound binding carbohydrate derivative binding hydrolase activity, acting on acid anhydrides catalytic activity ribonucleotide binding pyrophosphatase activity GTPase activity nucleoside-triphosphatase regulator activity GTPase regulator activity purine ribonucleoside triphosphate binding guanyl-nucleotide exchange factor activity nucleoside phosphate binding purine nucleotide binding hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides small molecule binding cation binding metal ion binding phosphorylation-dependent protein binding modification-dependent protein binding	regulation of immune effector process lymphocyte mediated immunity positive regulation of leukocyte mediated immunity positive regulation of response to biotic stimulus regulation of cellular process response to stimulus response to biotic stimulus positive regulation of leukocyte mediated cytotoxicity positive regulation of immune response positive regulation of natural killer cell mediated immunity leukocyte mediated immunity regulation of immune system process natural killer cell mediated immunity positive regulation of immune system process regulation of immune effector process lymphocyte mediated immunity positive regulation of leukocyte mediated immunity positive regulation of response to biotic stimulus regulation of cellular process response to stimulus response to biotic stimulus positive regulation of leukocyte mediated cytotoxicity positive regulation of immune response positive regulation of natural killer cell mediated immunity leukocyte mediated immunity regulation of immune system process natural killer cell mediated immunity positive regulation of immune system process regulation of biological process regulation of natural killer cell mediated immunity immune response response to other organism regulation of innate immune response response to external stimulus leukocyte mediated cytotoxicity immune effector process regulation of leukocyte mediated immunity regulation of response to stimulus defense response to other organism positive regulation of defense response natural killer cell mediated cytotoxicity regulation of immune response positive regulation of natural killer cell mediated cytotoxicity regulation of cell killing positive regulation of cell killing regulation of defense response regulation of response to biotic stimulus regulation of natural killer cell mediated cytotoxicity biological process involved in interspecies interaction between organisms regulation of response to external stimulus positive regulation of lymphocyte mediated immunity positive regulation of biological process positive regulation of response to stimulus positive regulation of response to external stimulus regulation of response to stress response to stress innate immune response positive regulation of immune effector process response to external biotic stimulus positive regulation of cellular process positive regulation of innate immune response defense response regulation of leukocyte mediated cytotoxicity biological regulation defense response to symbiont regulation of lymphocyte mediated immunity immune system process cellular process cell killing reactive oxygen species metabolic process metabolic process cellular component organization regulation of cellular component size cellular component organization or biogenesis regulation of biological quality regulation of cell size regulation of anatomical structure size cell chemotaxis cellular response to stimulus chemotaxis neutrophil chemotaxis neutrophil migration granulocyte migration leukocyte migration cellular response to chemical stimulus taxis granulocyte chemotaxis response to chemical myeloid leukocyte migration cell migration cell motility leukocyte chemotaxis locomotion integrin-mediated signaling pathway cell surface receptor signaling pathway signaling cell communication signal transduction positive regulation of cell communication regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of signal transduction regulation of signal transduction intracellular signal transduction regulation of intracellular signal transduction intracellular signaling cassette regulation of signaling positive regulation of intracellular signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of cell communication phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of signaling developmental process multicellular organismal process cellular developmental process hemopoiesis cell activation cell development mononuclear cell differentiation lymphocyte activation lymphocyte differentiation leukocyte activation T cell activation cell differentiation anatomical structure development T cell differentiation leukocyte differentiation regulation of body fluid levels wound healing hemostasis blood coagulation coagulation response to wounding platelet activation natural killer cell activation immune response-regulating cell surface receptor signaling pathway Fc receptor signaling pathway immune response-regulating signaling pathway Fc-epsilon receptor signaling pathway small GTPase-mediated signal transduction regulation of small GTPase mediated signal transduction cellular response to xenobiotic stimulus response to xenobiotic stimulus regulation of leukocyte activation regulation of cell activation positive regulation of leukocyte cell-cell adhesion leukocyte cell-cell adhesion positive regulation of cell-cell adhesion positive regulation of lymphocyte activation positive regulation of cell activation cell adhesion cell-cell adhesion positive regulation of leukocyte activation regulation of multicellular organismal process regulation of cell-cell adhesion positive regulation of T cell activation positive regulation of cell adhesion regulation of cell adhesion regulation of T cell activation lymphocyte costimulation regulation of leukocyte cell-cell adhesion positive regulation of multicellular organismal process T cell costimulation regulation of lymphocyte activation G protein-coupled receptor signaling pathway regulation of molecular function regulation of catalytic activity regulation of hydrolase activity regulation of GTPase activity cell surface receptor protein tyrosine kinase signaling pathway vascular endothelial growth factor receptor signaling pathway enzyme-linked receptor protein signaling pathway immune response-regulating cell surface receptor signaling pathway involved in phagocytosis import into cell transport Fc-gamma receptor signaling pathway involved in phagocytosis vesicle-mediated transport localization immune response-activating signaling pathway phagocytosis Fc-gamma receptor signaling pathway immune response-activating cell surface receptor signaling pathway Fc receptor mediated stimulatory signaling pathway establishment of localization endocytosis activation of immune response	cell-cell junction cellular anatomical structure anchoring junction cell junction intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane
B	Tyrosine-protein kinase SYK	protein binding binding signaling receptor binding Toll-like receptor binding protein tyrosine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups adenyl ribonucleotide binding nucleotide binding protein binding binding signaling receptor binding Toll-like receptor binding protein tyrosine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding non-membrane spanning protein tyrosine kinase activity scaffold protein binding kinase binding enzyme binding protein kinase binding protein serine/threonine kinase activity histone H2AXY142 kinase activity histone modifying activity histone kinase activity histone H2AX kinase activity histone H3Y41 kinase activity histone H3 kinase activity phosphoprotein binding phosphotyrosine residue binding protein phosphorylated amino acid binding phosphatase binding phospholipase binding cytokine receptor binding interleukin-15 receptor binding SH2 domain binding protein domain specific binding cell adhesion molecule binding protein-containing complex binding integrin binding	regulation of biological process regulation of cellular process reactive oxygen species metabolic process biological regulation positive regulation of biological process regulation of superoxide metabolic process positive regulation of reactive oxygen species metabolic process superoxide metabolic process positive regulation of metabolic process superoxide anion generation metabolic process cellular process positive regulation of superoxide anion generation regulation of superoxide anion generation regulation of biological process regulation of cellular process reactive oxygen species metabolic process biological regulation positive regulation of biological process regulation of superoxide metabolic process positive regulation of reactive oxygen species metabolic process superoxide metabolic process positive regulation of metabolic process superoxide anion generation metabolic process cellular process positive regulation of superoxide anion generation regulation of superoxide anion generation regulation of metabolic process regulation of reactive oxygen species metabolic process positive regulation of cellular process cellular response to stimulus positive regulation of cell communication positive regulation of signal transduction response to stimulus signaling regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette regulation of calcium-mediated signaling positive regulation of calcium-mediated signaling signal transduction regulation of signaling positive regulation of intracellular signal transduction regulation of response to stimulus calcium-mediated signaling regulation of cell communication positive regulation of signaling multicellular organismal process cell activation establishment of organelle localization regulation of immune effector process regulation of localization regulated exocytosis regulation of myeloid leukocyte mediated immunity cell activation involved in immune response leukocyte degranulation myeloid leukocyte activation myeloid leukocyte mediated immunity vesicle-mediated transport localization positive regulation of leukocyte degranulation positive regulation of regulated secretory pathway establishment of localization in cell leukocyte mediated immunity regulation of immune system process positive regulation of mast cell degranulation positive regulation of immune system process immune response vacuolar localization mast cell degranulation establishment of localization immune effector process regulation of secretion regulation of leukocyte mediated immunity exocytosis lysosome localization cellular localization transport positive regulation of secretion by cell positive regulation of exocytosis regulation of mast cell degranulation leukocyte activation regulation of regulated secretory pathway secretion by cell regulation of secretion by cell positive regulation of secretion organelle localization leukocyte activation involved in immune response mast cell activation positive regulation of immune effector process regulation of leukocyte degranulation mast cell mediated immunity secretion regulation of transport export from cell regulation of vesicle-mediated transport myeloid cell activation involved in immune response mast cell activation involved in immune response positive regulation of transport immune system process regulation of exocytosis neutrophil activation neutrophil activation involved in immune response regulation of immune response neutrophil mediated immunity regulation of neutrophil degranulation neutrophil degranulation granulocyte activation cell chemotaxis chemotaxis neutrophil chemotaxis response to external stimulus neutrophil migration granulocyte migration leukocyte migration cellular response to chemical stimulus taxis granulocyte chemotaxis response to chemical myeloid leukocyte migration cell migration cell motility leukocyte chemotaxis locomotion biological process involved in interspecies interaction between organisms response to other organism defense response response to biotic stimulus defense response to bacterium defense response to other organism response to stress response to bacterium response to external biotic stimulus positive regulation of interleukin-8 production positive regulation of macromolecule biosynthetic process positive regulation of biosynthetic process cytokine production regulation of cytokine production positive regulation of macromolecule metabolic process regulation of multicellular organismal process regulation of biosynthetic process interleukin-8 production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression positive regulation of multicellular organismal process regulation of macromolecule biosynthetic process macromolecule metabolic process positive regulation of cytokine production regulation of interleukin-8 production import into cell regulation of cellular component organization regulation of phagocytosis cellular component organization phagocytosis cellular component organization or biogenesis endocytosis regulation of endocytosis response to lectin cellular response to lectin interleukin-10 production regulation of interleukin-10 production positive regulation of interleukin-10 production cell adhesion cell-cell adhesion leukocyte cell-cell adhesion regulation of leukocyte differentiation regulation of leukocyte activation regulation of cell activation mononuclear cell differentiation regulation of cell differentiation positive regulation of B cell differentiation lymphocyte differentiation regulation of cell development positive regulation of developmental process positive regulation of cell activation multicellular organism development cell differentiation positive regulation of leukocyte activation anatomical structure development developmental process positive regulation of cell development leukocyte differentiation cellular developmental process regulation of developmental process cell development lymphocyte activation positive regulation of lymphocyte activation regulation of B cell differentiation B cell differentiation positive regulation of hemopoiesis positive regulation of cell differentiation regulation of B cell activation regulation of lymphocyte differentiation regulation of multicellular organismal development hemopoiesis B cell activation positive regulation of B cell activation regulation of hemopoiesis positive regulation of leukocyte differentiation positive regulation of lymphocyte differentiation regulation of lymphocyte activation positive regulation of type I interferon production type I interferon production regulation of type I interferon production blood vessel morphogenesis tube development vasculature development circulatory system development anatomical structure morphogenesis tube morphogenesis blood vessel development system development regulation of alpha-beta T cell activation positive regulation of T cell differentiation T cell activation alpha-beta T cell activation T cell differentiation positive regulation of T cell activation positive regulation of alpha-beta T cell activation regulation of leukocyte cell-cell adhesion positive regulation of alpha-beta T cell differentiation positive regulation of leukocyte cell-cell adhesion regulation of alpha-beta T cell differentiation positive regulation of cell-cell adhesion regulation of T cell differentiation alpha-beta T cell differentiation regulation of cell-cell adhesion positive regulation of cell adhesion regulation of cell adhesion regulation of T cell activation icosanoid metabolic process leukotriene metabolic process oxoacid metabolic process small molecule biosynthetic process leukotriene biosynthetic process carboxylic acid metabolic process organic acid metabolic process organic acid biosynthetic process carboxylic acid biosynthetic process icosanoid biosynthetic process small molecule metabolic process positive regulation of response to biotic stimulus immune response-regulating cell surface receptor signaling pathway pattern recognition receptor signaling pathway immune response-activating signaling pathway positive regulation of immune response innate immune response-activating signaling pathway immune response-activating cell surface receptor signaling pathway regulation of innate immune response positive regulation of defense response activation of innate immune response activation of immune response regulation of defense response regulation of response to biotic stimulus regulation of response to external stimulus innate immune response activating cell surface receptor signaling pathway positive regulation of response to external stimulus immune response-regulating signaling pathway regulation of response to stress innate immune response cell surface pattern recognition receptor signaling pathway positive regulation of innate immune response cell surface receptor signaling pathway defense response to symbiont collagen-activated tyrosine kinase receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway collagen-activated signaling pathway enzyme-linked receptor protein signaling pathway gamma-delta T cell activation gamma-delta T cell differentiation monoamine transport nitrogen compound transport serotonin secretion involved in inflammatory response organic hydroxy compound transport serotonin secretion by platelet signal release serotonin secretion serotonin production involved in inflammatory response production of molecular mediator involved in inflammatory response platelet degranulation cell-cell signaling serotonin transport exocytic process inflammatory response regulation of interleukin-12 production interleukin-12 production positive regulation of interleukin-12 production cell death apoptotic signaling pathway apoptotic process programmed cell death G protein-coupled receptor signaling pathway regulation of tumor necrosis factor production positive regulation of tumor necrosis factor superfamily cytokine production tumor necrosis factor superfamily cytokine production positive regulation of tumor necrosis factor production tumor necrosis factor production regulation of tumor necrosis factor superfamily cytokine production response to cytokine cytokine-mediated signaling pathway response to peptide cellular response to cytokine stimulus interleukin-3-mediated signaling pathway cellular response to nitrogen compound response to oxygen-containing compound response to nitrogen compound cellular response to amyloid-beta cellular response to oxygen-containing compound response to amyloid-beta lymph vessel development regulation of protein modification process positive regulation of phosphorylation regulation of protein phosphorylation positive regulation of protein metabolic process peptidyl-tyrosine modification positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein modification process regulation of phosphate metabolic process peptidyl-amino acid modification phosphate-containing compound metabolic process protein metabolic process protein modification process phosphorus metabolic process positive regulation of protein phosphorylation protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process regulation of peptidyl-tyrosine phosphorylation primary metabolic process macromolecule modification regulation of phosphorylation regulation of phosphorus metabolic process peptidyl-tyrosine phosphorylation adaptive immune response beta selection T cell selection receptor internalization receptor-mediated endocytosis positive regulation of cellular component organization protein-containing complex organization positive regulation of cellular component biogenesis regulation of cellular component biogenesis cellular component biogenesis positive regulation of protein-containing complex assembly regulation of protein-containing complex assembly cellular component assembly protein-containing complex assembly cellular response to molecule of fungal origin cellular response to biotic stimulus response to molecule of fungal origin response to fungus protein localization establishment of protein localization nucleocytoplasmic transport nuclear transport intracellular transport protein localization to nucleus import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization macromolecule localization protein localization to organelle protein import into nucleus intracellular protein transport macrophage activation involved in immune response macrophage activation positive regulation of myeloid leukocyte cytokine production involved in immune response mast cell cytokine production myeloid leukocyte cytokine production cytokine production involved in immune response production of molecular mediator of immune response regulation of cytokine production involved in immune response regulation of mast cell cytokine production positive regulation of cytokine production involved in immune response positive regulation of production of molecular mediator of immune response regulation of production of molecular mediator of immune response positive regulation of mast cell cytokine production cellular response to low-density lipoprotein particle stimulus response to endogenous stimulus response to lipoprotein particle cellular response to lipoprotein particle stimulus regulation of MAPK cascade MAPK cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade regulation of body fluid levels wound healing hemostasis blood coagulation regulation of platelet activation coagulation regulation of biological quality response to wounding platelet activation homeostatic process regulation of bone remodeling tissue homeostasis regulation of tissue remodeling regulation of bone resorption bone resorption multicellular organismal-level homeostasis tissue remodeling bone remodeling anatomical structure homeostasis positive regulation of bone resorption cellular response to tumor necrosis factor tumor necrosis factor-mediated signaling pathway regulation of tumor necrosis factor-mediated signaling pathway regulation of cytokine-mediated signaling pathway regulation of response to cytokine stimulus response to tumor necrosis factor B cell receptor signaling pathway antigen receptor-mediated signaling pathway regulation of gamma-delta T cell differentiation regulation of gamma-delta T cell activation positive regulation of gamma-delta T cell differentiation positive regulation of gamma-delta T cell activation angiogenesis anatomical structure formation involved in morphogenesis interleukin-6 production positive regulation of interleukin-6 production regulation of interleukin-6 production positive regulation of cell population proliferation positive regulation of alpha-beta T cell proliferation alpha-beta T cell proliferation lymphocyte proliferation regulation of leukocyte proliferation cell population proliferation positive regulation of lymphocyte proliferation positive regulation of T cell proliferation regulation of cell population proliferation mononuclear cell proliferation positive regulation of leukocyte proliferation leukocyte proliferation regulation of alpha-beta T cell proliferation positive regulation of mononuclear cell proliferation T cell proliferation regulation of lymphocyte proliferation regulation of T cell proliferation regulation of mononuclear cell proliferation regulation of receptor internalization positive regulation of endocytosis positive regulation of receptor-mediated endocytosis regulation of receptor-mediated endocytosis positive regulation of receptor internalization amyloid-beta clearance integrin-mediated signaling pathway stimulatory C-type lectin receptor signaling pathway regulation of monocyte chemotactic protein-1 production positive regulation of monocyte chemotactic protein-1 production monocyte chemotactic protein-1 production regulation of chemokine production chemokine production positive regulation of chemokine production regulation of lipid transport regulation of arachidonate secretion arachidonate secretion monocarboxylic acid transport fatty acid transport icosanoid transport regulation of icosanoid secretion icosanoid secretion long-chain fatty acid transport organic anion transport carboxylic acid transport arachidonate transport lipid localization lipid transport regulation of fatty acid transport organic acid transport regulation of lipid localization regulation of organic acid transport positive regulation of TORC1 signaling positive regulation of TOR signaling regulation of TORC1 signaling TOR signaling regulation of TOR signaling TORC1 signaling positive regulation of cell adhesion mediated by integrin regulation of cell adhesion mediated by integrin cell adhesion mediated by integrin adaptive thermogenesis regulation of cold-induced thermogenesis cold-induced thermogenesis temperature homeostasis positive regulation of cold-induced thermogenesis positive regulation of MAPK cascade granulocyte macrophage colony-stimulating factor production positive regulation of granulocyte macrophage colony-stimulating factor production regulation of granulocyte macrophage colony-stimulating factor production positive regulation of interleukin-3 production interleukin-3 production regulation of interleukin-3 production homotypic cell-cell adhesion regulation of homotypic cell-cell adhesion platelet aggregation regulation of platelet aggregation regulation of interleukin-4 production positive regulation of interleukin-4 production interleukin-4 production response to lipid cellular response to lipid	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle early phagosome intracellular vesicle phagocytic vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle organelle vesicle endocytic vesicle cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle early phagosome intracellular vesicle phagocytic vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle organelle vesicle endocytic vesicle protein-containing complex plasma membrane protein complex membrane plasma membrane membrane protein complex immunoglobulin complex receptor complex B cell receptor complex cell periphery plasma membrane signaling receptor complex T cell receptor complex nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR003096	Smooth muscle protein/calponin	Family
A	IPR001849	Pleckstrin homology domain	Domain
A	IPR036860	SH2 domain superfamily	Homologous Superfamily
A	IPR000980	SH2 domain	Domain
A	IPR000219	Dbl homology domain	Domain
A	IPR001715	Calponin homology domain	Domain
A	IPR036028	SH3-like domain superfamily	Homologous Superfamily
A	IPR035730	VAV1 protein, first SH3 domain	Domain
A	IPR011993	PH-like domain superfamily	Homologous Superfamily
A	IPR001331	Guanine-nucleotide dissociation stimulator, CDC24, conserved site	Conserved Site
A	IPR035729	VAV1 protein, second SH3 domain	Domain
A	IPR002219	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain	Domain
A	IPR001452	SH3 domain	Domain
A	IPR035879	VAV1, SH2 domain	Domain
A	IPR036872	CH domain superfamily	Homologous Superfamily
A	IPR022613	Calmodulin-regulated spectrin-associated protein-like, Calponin-homology domain	Domain
A	IPR037832	Vav, PH domain	Domain
A	IPR035899	Dbl homology (DH) domain superfamily	Homologous Superfamily
B	IPR020635	Tyrosine-protein kinase, catalytic domain	Domain
B	IPR000719	Protein kinase domain	Domain
B	IPR012234	Tyrosine-protein kinase, non-receptor SYK/ZAP-70	Family
B	IPR017441	Protein kinase, ATP binding site	Binding Site
B	IPR036860	SH2 domain superfamily	Homologous Superfamily
B	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	Domain
B	IPR008266	Tyrosine-protein kinase, active site	Active Site
B	IPR023420	Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domain superfamily	Homologous Superfamily
B	IPR035838	SYK/ZAP-70, N-terminal SH2 domain	Domain
B	IPR000980	SH2 domain	Domain
B	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
B	IPR050198	Non-receptor tyrosine kinases involved in cell signaling	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P15498	adult T-cell leukemia/lymphoma medulloblastoma childhood medulloblastoma Liver Cirrhosis, Experimental medullomyoblastoma with myogenic differentiation adult medulloblastoma melanotic medulloblastoma acute T cell leukemia interstitial cystitis osteosarcoma wet macular degeneration age-related macular degeneration cutaneous lupus erythematosus spina bifida cancer adult T-cell leukemia/lymphoma medulloblastoma childhood medulloblastoma Liver Cirrhosis, Experimental medullomyoblastoma with myogenic differentiation adult medulloblastoma melanotic medulloblastoma acute T cell leukemia interstitial cystitis osteosarcoma wet macular degeneration age-related macular degeneration cutaneous lupus erythematosus spina bifida cancer desmoplastic/nodular medulloblastoma lung adenocarcinoma subependymal giant cell astrocytoma