2VK1
Crystal structure of the Saccharomyces cerevisiae pyruvate decarboxylase variant D28A in complex with its substrate
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
B | SCOP2B Superfamily | Thiamin diphosphate-binding fold (THDP-binding) | 8044266 | 3001790 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | DHS-like NAD/FAD-binding domain | 8044248 | 3001728 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | Thiamin diphosphate-binding fold (THDP-binding) | 8044267 | 3001790 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | DHS-like NAD/FAD-binding domain | 8044248 | 3001728 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | Thiamin diphosphate-binding fold (THDP-binding) | 8044266 | 3001790 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | Thiamin diphosphate-binding fold (THDP-binding) | 8044267 | 3001790 | SCOP2B (2022-06-29) |
C | SCOP2B Superfamily | DHS-like NAD/FAD-binding domain | 8044248 | 3001728 | SCOP2B (2022-06-29) |
C | SCOP2B Superfamily | Thiamin diphosphate-binding fold (THDP-binding) | 8044267 | 3001790 | SCOP2B (2022-06-29) |
C | SCOP2B Superfamily | Thiamin diphosphate-binding fold (THDP-binding) | 8044266 | 3001790 | SCOP2B (2022-06-29) |
D | SCOP2B Superfamily | Thiamin diphosphate-binding fold (THDP-binding) | 8044266 | 3001790 | SCOP2B (2022-06-29) |
D | SCOP2B Superfamily | DHS-like NAD/FAD-binding domain | 8044248 | 3001728 | SCOP2B (2022-06-29) |
D | SCOP2B Superfamily | Thiamin diphosphate-binding fold (THDP-binding) | 8044267 | 3001790 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
B | TPP_enzyme_M | e2vk1B1 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: DHS-like NAD/FAD-binding domain | F: TPP_enzyme_M | ECOD (1.6) |
B | TPP_enzyme_C | e2vk1B3 | A: a/b three-layered sandwiches | X: Thiamin diphosphate-binding fold (THDP-binding) (From Topology) | H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology) | T: Thiamin diphosphate-binding fold (THDP-binding) | F: TPP_enzyme_C | ECOD (1.6) |
B | TPP_enzyme_N | e2vk1B2 | A: a/b three-layered sandwiches | X: Thiamin diphosphate-binding fold (THDP-binding) (From Topology) | H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology) | T: Thiamin diphosphate-binding fold (THDP-binding) | F: TPP_enzyme_N | ECOD (1.6) |
A | TPP_enzyme_M | e2vk1A1 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: DHS-like NAD/FAD-binding domain | F: TPP_enzyme_M | ECOD (1.6) |
A | TPP_enzyme_C | e2vk1A3 | A: a/b three-layered sandwiches | X: Thiamin diphosphate-binding fold (THDP-binding) (From Topology) | H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology) | T: Thiamin diphosphate-binding fold (THDP-binding) | F: TPP_enzyme_C | ECOD (1.6) |
A | TPP_enzyme_N | e2vk1A2 | A: a/b three-layered sandwiches | X: Thiamin diphosphate-binding fold (THDP-binding) (From Topology) | H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology) | T: Thiamin diphosphate-binding fold (THDP-binding) | F: TPP_enzyme_N | ECOD (1.6) |
C | TPP_enzyme_M | e2vk1C1 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: DHS-like NAD/FAD-binding domain | F: TPP_enzyme_M | ECOD (1.6) |
C | TPP_enzyme_C | e2vk1C3 | A: a/b three-layered sandwiches | X: Thiamin diphosphate-binding fold (THDP-binding) (From Topology) | H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology) | T: Thiamin diphosphate-binding fold (THDP-binding) | F: TPP_enzyme_C | ECOD (1.6) |
C | TPP_enzyme_N | e2vk1C2 | A: a/b three-layered sandwiches | X: Thiamin diphosphate-binding fold (THDP-binding) (From Topology) | H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology) | T: Thiamin diphosphate-binding fold (THDP-binding) | F: TPP_enzyme_N | ECOD (1.6) |
D | TPP_enzyme_M | e2vk1D1 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: DHS-like NAD/FAD-binding domain | F: TPP_enzyme_M | ECOD (1.6) |
D | TPP_enzyme_C | e2vk1D3 | A: a/b three-layered sandwiches | X: Thiamin diphosphate-binding fold (THDP-binding) (From Topology) | H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology) | T: Thiamin diphosphate-binding fold (THDP-binding) | F: TPP_enzyme_C | ECOD (1.6) |
D | TPP_enzyme_N | e2vk1D2 | A: a/b three-layered sandwiches | X: Thiamin diphosphate-binding fold (THDP-binding) (From Topology) | H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology) | T: Thiamin diphosphate-binding fold (THDP-binding) | F: TPP_enzyme_N | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
B | 3.40.50.970 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domains | CATH (4.3.0) |
B | 3.40.50.1220 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | TPP-binding domain | CATH (4.3.0) |
A | 3.40.50.970 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domains | CATH (4.3.0) |
A | 3.40.50.1220 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | TPP-binding domain | CATH (4.3.0) |
C | 3.40.50.970 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domains | CATH (4.3.0) |
C | 3.40.50.1220 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | TPP-binding domain | CATH (4.3.0) |
D | 3.40.50.970 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domains | CATH (4.3.0) |
D | 3.40.50.1220 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | TPP-binding domain | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF00205 | Thiamine pyrophosphate enzyme, central domain (TPP_enzyme_M) | Thiamine pyrophosphate enzyme, central domain | The central domain of TPP enzymes contains a 2-fold Rossman fold. | Domain | |
PF02775 | Thiamine pyrophosphate enzyme, C-terminal TPP binding domain (TPP_enzyme_C) | Thiamine pyrophosphate enzyme, C-terminal TPP binding domain | - | Domain | |
PF02776 | Thiamine pyrophosphate enzyme, N-terminal TPP binding domain (TPP_enzyme_N) | Thiamine pyrophosphate enzyme, N-terminal TPP binding domain | - | Domain |