Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Bd2vk1b2 Alpha and beta proteins (a/b) DHS-like NAD/FAD-binding domain DHS-like NAD/FAD-binding domain automated matches automated matches YEAST (Saccharomyces cerevisiae ) [TaxId: 4932 ], SCOPe (2.08)
Bd2vk1b1 Alpha and beta proteins (a/b) Thiamin diphosphate-binding fold (THDP-binding) Thiamin diphosphate-binding fold (THDP-binding) automated matches automated matches YEAST (Saccharomyces cerevisiae ) [TaxId: 4932 ], SCOPe (2.08)
Ad2vk1a2 Alpha and beta proteins (a/b) DHS-like NAD/FAD-binding domain DHS-like NAD/FAD-binding domain automated matches automated matches YEAST (Saccharomyces cerevisiae ) [TaxId: 4932 ], SCOPe (2.08)
Ad2vk1a1 Alpha and beta proteins (a/b) Thiamin diphosphate-binding fold (THDP-binding) Thiamin diphosphate-binding fold (THDP-binding) automated matches automated matches YEAST (Saccharomyces cerevisiae ) [TaxId: 4932 ], SCOPe (2.08)
Cd2vk1c2 Alpha and beta proteins (a/b) DHS-like NAD/FAD-binding domain DHS-like NAD/FAD-binding domain automated matches automated matches YEAST (Saccharomyces cerevisiae ) [TaxId: 4932 ], SCOPe (2.08)
Cd2vk1c1 Alpha and beta proteins (a/b) Thiamin diphosphate-binding fold (THDP-binding) Thiamin diphosphate-binding fold (THDP-binding) automated matches automated matches YEAST (Saccharomyces cerevisiae ) [TaxId: 4932 ], SCOPe (2.08)
Dd2vk1d2 Alpha and beta proteins (a/b) DHS-like NAD/FAD-binding domain DHS-like NAD/FAD-binding domain automated matches automated matches YEAST (Saccharomyces cerevisiae ) [TaxId: 4932 ], SCOPe (2.08)
Dd2vk1d1 Alpha and beta proteins (a/b) Thiamin diphosphate-binding fold (THDP-binding) Thiamin diphosphate-binding fold (THDP-binding) automated matches automated matches YEAST (Saccharomyces cerevisiae ) [TaxId: 4932 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
BSCOP2B SuperfamilyThiamin diphosphate-binding fold (THDP-binding) 8044266 3001790 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyDHS-like NAD/FAD-binding domain 8044248 3001728 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyThiamin diphosphate-binding fold (THDP-binding) 8044267 3001790 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyDHS-like NAD/FAD-binding domain 8044248 3001728 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyThiamin diphosphate-binding fold (THDP-binding) 8044266 3001790 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyThiamin diphosphate-binding fold (THDP-binding) 8044267 3001790 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyDHS-like NAD/FAD-binding domain 8044248 3001728 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyThiamin diphosphate-binding fold (THDP-binding) 8044267 3001790 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyThiamin diphosphate-binding fold (THDP-binding) 8044266 3001790 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyThiamin diphosphate-binding fold (THDP-binding) 8044266 3001790 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyDHS-like NAD/FAD-binding domain 8044248 3001728 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyThiamin diphosphate-binding fold (THDP-binding) 8044267 3001790 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
BTPP_enzyme_Me2vk1B1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: DHS-like NAD/FAD-binding domainF: TPP_enzyme_MECOD (1.6)
BTPP_enzyme_Ce2vk1B3 A: a/b three-layered sandwichesX: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)T: Thiamin diphosphate-binding fold (THDP-binding)F: TPP_enzyme_CECOD (1.6)
BTPP_enzyme_Ne2vk1B2 A: a/b three-layered sandwichesX: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)T: Thiamin diphosphate-binding fold (THDP-binding)F: TPP_enzyme_NECOD (1.6)
ATPP_enzyme_Me2vk1A1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: DHS-like NAD/FAD-binding domainF: TPP_enzyme_MECOD (1.6)
ATPP_enzyme_Ce2vk1A3 A: a/b three-layered sandwichesX: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)T: Thiamin diphosphate-binding fold (THDP-binding)F: TPP_enzyme_CECOD (1.6)
ATPP_enzyme_Ne2vk1A2 A: a/b three-layered sandwichesX: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)T: Thiamin diphosphate-binding fold (THDP-binding)F: TPP_enzyme_NECOD (1.6)
CTPP_enzyme_Me2vk1C1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: DHS-like NAD/FAD-binding domainF: TPP_enzyme_MECOD (1.6)
CTPP_enzyme_Ce2vk1C3 A: a/b three-layered sandwichesX: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)T: Thiamin diphosphate-binding fold (THDP-binding)F: TPP_enzyme_CECOD (1.6)
CTPP_enzyme_Ne2vk1C2 A: a/b three-layered sandwichesX: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)T: Thiamin diphosphate-binding fold (THDP-binding)F: TPP_enzyme_NECOD (1.6)
DTPP_enzyme_Me2vk1D1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: DHS-like NAD/FAD-binding domainF: TPP_enzyme_MECOD (1.6)
DTPP_enzyme_Ce2vk1D3 A: a/b three-layered sandwichesX: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)T: Thiamin diphosphate-binding fold (THDP-binding)F: TPP_enzyme_CECOD (1.6)
DTPP_enzyme_Ne2vk1D2 A: a/b three-layered sandwichesX: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)T: Thiamin diphosphate-binding fold (THDP-binding)F: TPP_enzyme_NECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D
PF00205Thiamine pyrophosphate enzyme, central domain (TPP_enzyme_M)Thiamine pyrophosphate enzyme, central domainThe central domain of TPP enzymes contains a 2-fold Rossman fold.Domain
A, B, C, D
PF02775Thiamine pyrophosphate enzyme, C-terminal TPP binding domain (TPP_enzyme_C)Thiamine pyrophosphate enzyme, C-terminal TPP binding domain- Domain
A, B, C, D
PF02776Thiamine pyrophosphate enzyme, N-terminal TPP binding domain (TPP_enzyme_N)Thiamine pyrophosphate enzyme, N-terminal TPP binding domain- Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C, D
PYRUVATE DECARBOXYLASE ISOZYME 1