2XFB | pdb_00002xfb

CHIKUNGUNYA E1 E2 ENVELOPE GLYCOPROTEINS FITTED IN SINDBIS VIRUS cryo- EM MAP

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Alpha_E1_glycop_2nd	e2xfbA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Alpha_E1_glycop_2nd	ECOD (1.6)
A	Alpha_E1_glycop_1st	e2xfbA2	A: beta complex topology	X: Viral glycoprotein, central and dimerisation domains-like	H: Viral glycoprotein, central and dimerisation domains (From Topology)	T: Viral glycoprotein, central and dimerisation domains	F: Alpha_E1_glycop_1st	ECOD (1.6)
C [auth D]	Alpha_E1_glycop_2nd	e2xfbD1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Alpha_E1_glycop_2nd	ECOD (1.6)
C [auth D]	Alpha_E1_glycop_1st	e2xfbD2	A: beta complex topology	X: Viral glycoprotein, central and dimerisation domains-like	H: Viral glycoprotein, central and dimerisation domains (From Topology)	T: Viral glycoprotein, central and dimerisation domains	F: Alpha_E1_glycop_1st	ECOD (1.6)
E [auth F]	Alpha_E1_glycop_2nd	e2xfbF1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Alpha_E1_glycop_2nd	ECOD (1.6)
E [auth F]	Alpha_E1_glycop_1st	e2xfbF2	A: beta complex topology	X: Viral glycoprotein, central and dimerisation domains-like	H: Viral glycoprotein, central and dimerisation domains (From Topology)	T: Viral glycoprotein, central and dimerisation domains	F: Alpha_E1_glycop_1st	ECOD (1.6)
G [auth H]	Alpha_E1_glycop_2nd	e2xfbH1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Alpha_E1_glycop_2nd	ECOD (1.6)
G [auth H]	Alpha_E1_glycop_1st	e2xfbH2	A: beta complex topology	X: Viral glycoprotein, central and dimerisation domains-like	H: Viral glycoprotein, central and dimerisation domains (From Topology)	T: Viral glycoprotein, central and dimerisation domains	F: Alpha_E1_glycop_1st	ECOD (1.6)
D [auth E]	Alpha_E2_glycop_2nd	e2xfbE2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Alpha_E2_glycop_2nd	ECOD (1.6)
D [auth E]	Alpha_E2_glycop_1st	e2xfbE1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Alpha_E2_glycop_1st	ECOD (1.6)
D [auth E]	Alpha_E2_glycop_3rd	e2xfbE3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Alpha_E2_glycop_3rd	ECOD (1.6)
B	Alpha_E2_glycop_2nd	e2xfbB2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Alpha_E2_glycop_2nd	ECOD (1.6)
B	Alpha_E2_glycop_1st	e2xfbB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Alpha_E2_glycop_1st	ECOD (1.6)
B	Alpha_E2_glycop_3rd	e2xfbB3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Alpha_E2_glycop_3rd	ECOD (1.6)
F [auth G]	Alpha_E2_glycop_2nd	e2xfbG2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Alpha_E2_glycop_2nd	ECOD (1.6)
F [auth G]	Alpha_E2_glycop_1st	e2xfbG1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Alpha_E2_glycop_1st	ECOD (1.6)
F [auth G]	Alpha_E2_glycop_3rd	e2xfbG3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Alpha_E2_glycop_3rd	ECOD (1.6)
H [auth I]	Alpha_E2_glycop_2nd	e2xfbI2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Alpha_E2_glycop_2nd	ECOD (1.6)
H [auth I]	Alpha_E2_glycop_1st	e2xfbI1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Alpha_E2_glycop_1st	ECOD (1.6)
H [auth I]	Alpha_E2_glycop_3rd	e2xfbI3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Alpha_E2_glycop_3rd	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C [auth D], E [auth F], G [auth H]	PF01589	Alphavirus E1 glycoprotein (Alpha_E1_glycop)	Alphavirus E1 glycoprotein	-	Family
B, D [auth E], F [auth G], H [auth I]	PF00943	Alphavirus E2 glycoprotein (Alpha_E2_glycop)	Alphavirus E2 glycoprotein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C [auth D], E [auth F], G [auth H]	E1 ENVELOPE GLYCOPROTEIN	peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity structural molecule activity identical protein binding protein binding binding	viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell biological process involved in interspecies interaction between organisms symbiont entry into host cell symbiont entry into host viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction virion attachment to host cell adhesion of symbiont to host cell adhesion of symbiont to host proteolysis metabolic process viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell biological process involved in interspecies interaction between organisms symbiont entry into host cell symbiont entry into host viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction virion attachment to host cell adhesion of symbiont to host cell adhesion of symbiont to host proteolysis metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process	cellular anatomical structure membrane host cell plasma membrane host cellular component host cell part host cell membrane host intracellular part host cell cytoplasm host intracellular region virion component virion membrane viral capsid icosahedral viral capsid T=4 icosahedral viral capsid
B, D [auth E], F [auth G], H [auth I]	E2 ENVELOPE GLYCOPROTEIN	peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity structural molecule activity identical protein binding protein binding binding	viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell biological process involved in interspecies interaction between organisms symbiont entry into host cell symbiont entry into host viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction virion attachment to host cell adhesion of symbiont to host cell adhesion of symbiont to host proteolysis metabolic process viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell biological process involved in interspecies interaction between organisms symbiont entry into host cell symbiont entry into host viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction virion attachment to host cell adhesion of symbiont to host cell adhesion of symbiont to host proteolysis metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process	cellular anatomical structure membrane host cell plasma membrane host cellular component host cell part host cell membrane host intracellular part host cell cytoplasm host intracellular region virion component virion membrane viral capsid icosahedral viral capsid T=4 icosahedral viral capsid

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C [auth D], E [auth F], G [auth H]	IPR002533	Alphavirus E3 spike glycoprotein	Domain
A, C [auth D], E [auth F], G [auth H]	IPR038055	Flaviviral glycoprotein E, dimerisation domain	Homologous Superfamily
A, C [auth D], E [auth F], G [auth H]	IPR014756	Immunoglobulin E-set	Homologous Superfamily
A, C [auth D], E [auth F], G [auth H]	IPR042304	Alphavirus E2 glycoprotein, domain A	Homologous Superfamily
A, C [auth D], E [auth F], G [auth H]	IPR036253	Flavivirus glycoprotein, central and dimerisation domain superfamily	Homologous Superfamily
A, C [auth D], E [auth F], G [auth H]	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
A, C [auth D], E [auth F], G [auth H]	IPR042305	Alphavirus E2 glycoprotein, domain B	Homologous Superfamily
A, C [auth D], E [auth F], G [auth H]	IPR042306	Alphavirus E2 glycoprotein, domain C	Homologous Superfamily
A, C [auth D], E [auth F], G [auth H]	IPR000936	Alphavirus E2 glycoprotein	Family
A, C [auth D], E [auth F], G [auth H]	IPR000930	Peptidase S3, togavirin	Domain
A, C [auth D], E [auth F], G [auth H]	IPR002548	Alphavirus E1 glycoprotein	Domain
A, C [auth D], E [auth F], G [auth H]	IPR000336	Flavivirus/Alphavirus glycoprotein, immunoglobulin-like domain superfamily	Homologous Superfamily
A, C [auth D], E [auth F], G [auth H]	IPR043504	Peptidase S1, PA clan, chymotrypsin-like fold	Homologous Superfamily
B, D [auth E], F [auth G], H [auth I]	IPR002533	Alphavirus E3 spike glycoprotein	Domain
B, D [auth E], F [auth G], H [auth I]	IPR038055	Flaviviral glycoprotein E, dimerisation domain	Homologous Superfamily
B, D [auth E], F [auth G], H [auth I]	IPR014756	Immunoglobulin E-set	Homologous Superfamily
B, D [auth E], F [auth G], H [auth I]	IPR042304	Alphavirus E2 glycoprotein, domain A	Homologous Superfamily
B, D [auth E], F [auth G], H [auth I]	IPR036253	Flavivirus glycoprotein, central and dimerisation domain superfamily	Homologous Superfamily
B, D [auth E], F [auth G], H [auth I]	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
B, D [auth E], F [auth G], H [auth I]	IPR042305	Alphavirus E2 glycoprotein, domain B	Homologous Superfamily
B, D [auth E], F [auth G], H [auth I]	IPR042306	Alphavirus E2 glycoprotein, domain C	Homologous Superfamily
B, D [auth E], F [auth G], H [auth I]	IPR000936	Alphavirus E2 glycoprotein	Family
B, D [auth E], F [auth G], H [auth I]	IPR000930	Peptidase S3, togavirin	Domain
B, D [auth E], F [auth G], H [auth I]	IPR002548	Alphavirus E1 glycoprotein	Domain
B, D [auth E], F [auth G], H [auth I]	IPR000336	Flavivirus/Alphavirus glycoprotein, immunoglobulin-like domain superfamily	Homologous Superfamily
B, D [auth E], F [auth G], H [auth I]	IPR043504	Peptidase S1, PA clan, chymotrypsin-like fold	Homologous Superfamily