3GMW

Crystal Structure of Beta-Lactamse Inhibitory Protein-I (BLIP-I) in Complex with TEM-1 Beta-Lactamase

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
AMR Gene: CARD Annotation
AMR Gene Family: CARD Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d3gmwb_	Alpha and beta proteins (a+b)	BLIP-like	beta-lactamase-inhibitor protein, BLIP	automated matches	automated matches	Streptomyces hydrogenans (Streptomyces exfoliatus ) [TaxId: 1905 ],	SCOPe (2.08)
D	d3gmwd_	Alpha and beta proteins (a+b)	BLIP-like	beta-lactamase-inhibitor protein, BLIP	automated matches	automated matches	Streptomyces hydrogenans (Streptomyces exfoliatus ) [TaxId: 1905 ],	SCOPe (2.08)
A	d3gmwa_	Multi-domain proteins (alpha and beta)	beta-lactamase/transpeptidase-like	beta-lactamase/transpeptidase-like	beta-Lactamase/D-ala carboxypeptidase	automated matches	(Escherichia sp. Sflu5 ) [TaxId: 299586 ],	SCOPe (2.08)
C	d3gmwc_	Multi-domain proteins (alpha and beta)	beta-lactamase/transpeptidase-like	beta-lactamase/transpeptidase-like	beta-Lactamase/D-ala carboxypeptidase	automated matches	(Escherichia sp. Sflu5 ) [TaxId: 299586 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2 Family	BLIP-like	8080342	4001739	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	BLIP repeat-like	8092095	3000321	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	BLIP repeat-like	8080343	3000321	SCOP2 (2022-06-29)
D	SCOP2B Superfamily	BLIP repeat-like	8092095	3000321	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	BLIP repeat-like	8080343	3000321	SCOP2B (2022-06-29)
A	SCOP2 Family	beta-Lactamase/D-ala carboxypeptidase	8069828	4002685	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	beta-lactamase/transpeptidase-like	8069829	3001604	SCOP2 (2022-06-29)
C	SCOP2B Superfamily	beta-lactamase/transpeptidase-like	8069829	3001604	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	BLIP	e3gmwB1	A: a+b two layers	X: BLIP-like	H: beta-lactamase-inhibitor protein, BLIP (From Topology)	T: beta-lactamase-inhibitor protein, BLIP	F: BLIP	ECOD (1.6)
D	BLIP	e3gmwD1	A: a+b two layers	X: BLIP-like	H: beta-lactamase-inhibitor protein, BLIP (From Topology)	T: beta-lactamase-inhibitor protein, BLIP	F: BLIP	ECOD (1.6)
A	Peptidase_S11_1st_1	e3gmwA3	A: alpha complex topology	X: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)	H: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)	T: alpha-helical domain in beta-lactamase/transpeptidase-like proteins	F: Peptidase_S11_1st_1	ECOD (1.6)
A	Beta-lactamase2	e3gmwA4	A: a+b three layers	X: Profilin-like	H: a+b domain in beta-lactamase/transpeptidase-like proteins (From Topology)	T: a+b domain in beta-lactamase/transpeptidase-like proteins	F: Beta-lactamase2	ECOD (1.6)
C	Peptidase_S11_1st_1	e3gmwC3	A: alpha complex topology	X: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)	H: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)	T: alpha-helical domain in beta-lactamase/transpeptidase-like proteins	F: Peptidase_S11_1st_1	ECOD (1.6)
C	Beta-lactamase2	e3gmwC4	A: a+b three layers	X: Profilin-like	H: a+b domain in beta-lactamase/transpeptidase-like proteins (From Topology)	T: a+b domain in beta-lactamase/transpeptidase-like proteins	F: Beta-lactamase2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.10.450.730	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
D	3.10.450.730	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
A	3.40.710.10	Alpha Beta	3-Layer(aba) Sandwich	Beta-lactamase	DD-peptidase/beta-lactamase superfamily	CATH (4.3.0)
C	3.40.710.10	Alpha Beta	3-Layer(aba) Sandwich	Beta-lactamase	DD-peptidase/beta-lactamase superfamily	CATH (4.3.0)

AMR Gene: CARD Annotation CARD Database Homepage

Chains	Accession	Short Name	Description	Provenance Source (Version)
A, C	ARO:3001044	TEM-181	TEM-181 is a beta-lactamase.	CARD (3.3.0)

AMR Gene Family: CARD Annotation CARD Database Homepage

Chains	Accession	Gene Family	Drug Class	Resistance Machanism	Provenance Source (Version)
A, C	ARO:3000014	TEM beta-lactamase	monobactam, cephalosporin, penam, penem	antibiotic inactivation	CARD (3.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B, D	PF07467	Beta-lactamase inhibitor (BLIP) (BLIP)	Beta-lactamase inhibitor (BLIP)	-	Family
A, C	PF13354	Beta-lactamase enzyme family (Beta-lactamase2)	Beta-lactamase enzyme family	This is the catalytic domain of class A beta-lactamases [1]. It is closely related to Beta-lactamase, Pfam:PF00144, the serine beta-lactamase-like superfamily, which contains the distantly related Pfam:PF00905 and PF00768 D-alanyl-D-alanine carboxype ...	This is the catalytic domain of class A beta-lactamases [1]. It is closely related to Beta-lactamase, Pfam:PF00144, the serine beta-lactamase-like superfamily, which contains the distantly related Pfam:PF00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	Domain
A, C	PF00144	Beta-lactamase (Beta-lactamase)	Beta-lactamase	This family appears to be distantly related to Pfam:PF00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B, D	Beta-lactamase inhibitory protein BLIP-I	-	-	-
A, C	B-lactamase	beta-lactamase activity hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides catalytic activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	beta-lactam antibiotic metabolic process catabolic process lactam catabolic process antibiotic catabolic process lactam metabolic process amine metabolic process antibiotic metabolic process beta-lactam antibiotic catabolic process metabolic process cellular process small molecule metabolic process amide metabolic process response to stimulus response to chemical beta-lactam antibiotic metabolic process catabolic process lactam catabolic process antibiotic catabolic process lactam metabolic process amine metabolic process antibiotic metabolic process beta-lactam antibiotic catabolic process metabolic process cellular process small molecule metabolic process amide metabolic process response to stimulus response to chemical response to antibiotic	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B, D	IPR024221	Beta-lactamase-inhibitor protein BLIP domain superfamily	Homologous Superfamily
B, D	IPR009099	Beta-lactamase-inhibitor protein BLIP	Family
A, C	IPR045155	Beta-lactamase class A, catalytic domain	Domain
A, C	IPR012338	Beta-lactamase/transpeptidase-like	Homologous Superfamily
A, C	IPR000871	Beta-lactamase, class-A	Family
A, C	IPR023650	Beta-lactamase, class-A active site	Active Site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.