Annotations: 3H2Z

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Mannitol_dh_C	e3h2zA3	A: alpha arrays	X: 6-phosphogluconate dehydrogenase C-terminal domain-like (From Topology)	H: 6-phosphogluconate dehydrogenase C-terminal domain-like (From Topology)	T: 6-phosphogluconate dehydrogenase C-terminal domain-like	F: Mannitol_dh_C	ECOD (1.6)
A	Mannitol_dh	e3h2zA4	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: Mannitol_dh	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)
A	1.10.1040.10	Mainly Alpha	Orthogonal Bundle	N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase	domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF08125	Mannitol dehydrogenase C-terminal domain (Mannitol_dh_C)	Mannitol dehydrogenase C-terminal domain		Domain
A	PF01232	Mannitol dehydrogenase Rossmann domain (Mannitol_dh)	Mannitol dehydrogenase Rossmann domain		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Mannitol-1-phosphate 5-dehydrogenase	mannitol-1-phosphate 5-dehydrogenase activity oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on CH-OH group of donors catalytic activity	carbohydrate metabolic process mannitol metabolic process hexitol metabolic process polyol metabolic process alcohol catabolic process catabolic process hexitol catabolic process polyol catabolic process carbohydrate catabolic process primary metabolic process alcohol metabolic process alditol catabolic process mannitol catabolic process alditol metabolic process carbohydrate metabolic process mannitol metabolic process hexitol metabolic process polyol metabolic process alcohol catabolic process catabolic process hexitol catabolic process polyol catabolic process carbohydrate catabolic process primary metabolic process alcohol metabolic process alditol catabolic process mannitol catabolic process alditol metabolic process metabolic process cellular process small molecule metabolic process small molecule catabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR023028	Mannitol-1-phosphate 5-dehydrogenase	Family
A	IPR036291	NAD(P)-binding domain superfamily	Homologous Superfamily
A	IPR000669	Mannitol dehydrogenase	Family
A	IPR013328	6-phosphogluconate dehydrogenase, domain 2	Homologous Superfamily
A	IPR023027	Mannitol dehydrogenase, conserved site	Conserved Site
A	IPR013118	Mannitol dehydrogenase, C-terminal	Domain
A	IPR013131	Mannitol dehydrogenase, N-terminal	Domain
A	IPR008927	6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.