Annotations: 3J2W

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
Q [auth I]	SCOP2 Family	Viral capsid proteases-like	8071556	4002263	SCOP2 (2022-06-29)
Q [auth I]	SCOP2 Superfamily	Trypsin-like serine proteases	8071557	3000114	SCOP2 (2022-06-29)
R [auth J]	SCOP2B Superfamily	Trypsin-like serine proteases	8071557	3000114	SCOP2B (2022-06-29)
T [auth L]	SCOP2B Superfamily	Trypsin-like serine proteases	8071557	3000114	SCOP2B (2022-06-29)
S [auth K]	SCOP2B Superfamily	Trypsin-like serine proteases	8071557	3000114	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Alpha_E1_glycop_2nd	e3j2wA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Alpha_E1_glycop_2nd	ECOD (1.6)
A	Alpha_E1_glycop_1st	e3j2wA2	A: beta complex topology	X: Viral glycoprotein, central and dimerisation domains-like	H: Viral glycoprotein, central and dimerisation domains (From Topology)	T: Viral glycoprotein, central and dimerisation domains	F: Alpha_E1_glycop_1st	ECOD (1.6)
C [auth B]	Alpha_E1_glycop_2nd	e3j2wB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Alpha_E1_glycop_2nd	ECOD (1.6)
C [auth B]	Alpha_E1_glycop_1st	e3j2wB2	A: beta complex topology	X: Viral glycoprotein, central and dimerisation domains-like	H: Viral glycoprotein, central and dimerisation domains (From Topology)	T: Viral glycoprotein, central and dimerisation domains	F: Alpha_E1_glycop_1st	ECOD (1.6)
E [auth C]	Alpha_E1_glycop_2nd	e3j2wC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Alpha_E1_glycop_2nd	ECOD (1.6)
E [auth C]	Alpha_E1_glycop_1st	e3j2wC2	A: beta complex topology	X: Viral glycoprotein, central and dimerisation domains-like	H: Viral glycoprotein, central and dimerisation domains (From Topology)	T: Viral glycoprotein, central and dimerisation domains	F: Alpha_E1_glycop_1st	ECOD (1.6)
G [auth D]	Alpha_E1_glycop_2nd	e3j2wD1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Alpha_E1_glycop_2nd	ECOD (1.6)
G [auth D]	Alpha_E1_glycop_1st	e3j2wD2	A: beta complex topology	X: Viral glycoprotein, central and dimerisation domains-like	H: Viral glycoprotein, central and dimerisation domains (From Topology)	T: Viral glycoprotein, central and dimerisation domains	F: Alpha_E1_glycop_1st	ECOD (1.6)
B [auth M]	Alpha_E2_glycop_2nd	e3j2wM2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Alpha_E2_glycop_2nd	ECOD (1.6)
B [auth M]	Alpha_E2_glycop_1st	e3j2wM1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Alpha_E2_glycop_1st	ECOD (1.6)
B [auth M]	Alpha_E2_glycop_3rd	e3j2wM3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Alpha_E2_glycop_3rd	ECOD (1.6)
D [auth N]	Alpha_E2_glycop_2nd	e3j2wN3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Alpha_E2_glycop_2nd	ECOD (1.6)
D [auth N]	Alpha_E2_glycop_1st	e3j2wN2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Alpha_E2_glycop_1st	ECOD (1.6)
D [auth N]	Alpha_E2_glycop_3rd	e3j2wN1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Alpha_E2_glycop_3rd	ECOD (1.6)
F [auth O]	Alpha_E2_glycop_2nd	e3j2wO3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Alpha_E2_glycop_2nd	ECOD (1.6)
F [auth O]	Alpha_E2_glycop_1st	e3j2wO2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Alpha_E2_glycop_1st	ECOD (1.6)
F [auth O]	Alpha_E2_glycop_3rd	e3j2wO1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Alpha_E2_glycop_3rd	ECOD (1.6)
H [auth P]	Alpha_E2_glycop_2nd	e3j2wP3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Alpha_E2_glycop_2nd	ECOD (1.6)
H [auth P]	Alpha_E2_glycop_1st	e3j2wP2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Alpha_E2_glycop_1st	ECOD (1.6)
H [auth P]	Alpha_E2_glycop_3rd	e3j2wP1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Alpha_E2_glycop_3rd	ECOD (1.6)
I [auth E]	Alpha_E1_glycop_like	e3j2wE1	A: extended segments	X: Transmembrane helix of E1 envelope glycoprotein (From Topology)	H: Transmembrane helix of E1 envelope glycoprotein (From Topology)	T: Transmembrane helix of E1 envelope glycoprotein	F: Alpha_E1_glycop_like	ECOD (1.6)
K [auth F]	Alpha_E1_glycop_like	e3j2wF1	A: extended segments	X: Transmembrane helix of E1 envelope glycoprotein (From Topology)	H: Transmembrane helix of E1 envelope glycoprotein (From Topology)	T: Transmembrane helix of E1 envelope glycoprotein	F: Alpha_E1_glycop_like	ECOD (1.6)
M [auth G]	Alpha_E1_glycop_like	e3j2wG1	A: extended segments	X: Transmembrane helix of E1 envelope glycoprotein (From Topology)	H: Transmembrane helix of E1 envelope glycoprotein (From Topology)	T: Transmembrane helix of E1 envelope glycoprotein	F: Alpha_E1_glycop_like	ECOD (1.6)
O [auth H]	Alpha_E1_glycop_like	e3j2wH1	A: extended segments	X: Transmembrane helix of E1 envelope glycoprotein (From Topology)	H: Transmembrane helix of E1 envelope glycoprotein (From Topology)	T: Transmembrane helix of E1 envelope glycoprotein	F: Alpha_E1_glycop_like	ECOD (1.6)
Q [auth I]	Peptidase_S3	e3j2wI1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel	F: Peptidase_S3	ECOD (1.6)
R [auth J]	Peptidase_S3	e3j2wJ1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel	F: Peptidase_S3	ECOD (1.6)
T [auth L]	Peptidase_S3	e3j2wL1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel	F: Peptidase_S3	ECOD (1.6)
S [auth K]	Peptidase_S3	e3j2wK1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel	F: Peptidase_S3	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C [auth B], E [auth C], G [auth D]	PF01589	Alphavirus E1 glycoprotein (Alpha_E1_glycop)	Alphavirus E1 glycoprotein	-	Family
B [auth M], D [auth N], F [auth O]	PF00943	Alphavirus E2 glycoprotein (Alpha_E2_glycop)	Alphavirus E2 glycoprotein	-	Family
H [auth P]	PF00943	Alphavirus E2 glycoprotein (Alpha_E2_glycop)	Alphavirus E2 glycoprotein	-	Family
Q [auth I], R [auth J], S [auth K], T [auth L]	PF00944	Alphavirus core protein (Peptidase_S3)	Alphavirus core protein	Also known as coat protein C and capsid protein C. This makes the literature very confusing. Alphaviruses consist of a nucleoprotein core, a lipid membrane which envelopes the core, and glycoprotein spikes protruding from the lipid membrane.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C [auth B], E [auth C], G [auth D]	Glycoprotein E1	peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity structural molecule activity identical protein binding protein binding binding	viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell biological process involved in interspecies interaction between organisms symbiont entry into host cell symbiont entry into host viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction virion attachment to host cell adhesion of symbiont to host cell adhesion of symbiont to host proteolysis metabolic process viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell biological process involved in interspecies interaction between organisms symbiont entry into host cell symbiont entry into host viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction virion attachment to host cell adhesion of symbiont to host cell adhesion of symbiont to host proteolysis metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process	cellular anatomical structure membrane host cell plasma membrane host cellular component host cell part host cell membrane host intracellular part host cell cytoplasm host intracellular region virion component virion membrane viral capsid icosahedral viral capsid T=4 icosahedral viral capsid
B [auth M], D [auth N], F [auth O]	Glycoprotein E2	peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity structural molecule activity identical protein binding protein binding binding	viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell biological process involved in interspecies interaction between organisms symbiont entry into host cell symbiont entry into host viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction virion attachment to host cell adhesion of symbiont to host cell adhesion of symbiont to host proteolysis metabolic process viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell biological process involved in interspecies interaction between organisms symbiont entry into host cell symbiont entry into host viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction virion attachment to host cell adhesion of symbiont to host cell adhesion of symbiont to host proteolysis metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process	cellular anatomical structure membrane host cell plasma membrane host cellular component host cell part host cell membrane host intracellular part host cell cytoplasm host intracellular region virion component virion membrane viral capsid icosahedral viral capsid T=4 icosahedral viral capsid
H [auth P]	Glycoprotein E2	peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity structural molecule activity identical protein binding protein binding binding	viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell biological process involved in interspecies interaction between organisms symbiont entry into host cell symbiont entry into host viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction virion attachment to host cell adhesion of symbiont to host cell adhesion of symbiont to host proteolysis metabolic process viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell biological process involved in interspecies interaction between organisms symbiont entry into host cell symbiont entry into host viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction virion attachment to host cell adhesion of symbiont to host cell adhesion of symbiont to host proteolysis metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process	cellular anatomical structure membrane host cell plasma membrane host cellular component host cell part host cell membrane host intracellular part host cell cytoplasm host intracellular region virion component virion membrane viral capsid icosahedral viral capsid T=4 icosahedral viral capsid
I [auth E], K [auth F], M [auth G], O [auth H]	Glycoprotein E1	peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity RNA binding binding nucleic acid binding structural molecule activity	viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell biological process involved in interspecies interaction between organisms symbiont entry into host cell symbiont entry into host viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction symbiont-mediated suppression of host signal transduction pathway symbiont-mediated perturbation of host cellular process symbiont-mediated perturbation of host process symbiont-mediated suppression of host toll-like receptor signaling pathway symbiont-mediated perturbation of host signal transduction pathway viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell biological process involved in interspecies interaction between organisms symbiont entry into host cell symbiont entry into host viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction symbiont-mediated suppression of host signal transduction pathway symbiont-mediated perturbation of host cellular process symbiont-mediated perturbation of host process symbiont-mediated suppression of host toll-like receptor signaling pathway symbiont-mediated perturbation of host signal transduction pathway modulation of process of another organism virion attachment to host cell adhesion of symbiont to host cell adhesion of symbiont to host proteolysis metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process	cellular anatomical structure membrane host cell plasma membrane host cellular component host cell part host cell membrane host intracellular part host cell cytoplasm host intracellular region virion component virion membrane viral capsid icosahedral viral capsid T=4 icosahedral viral capsid cellular anatomical structure membrane host cell plasma membrane host cellular component host cell part host cell membrane host intracellular part host cell cytoplasm host intracellular region virion component virion membrane viral capsid icosahedral viral capsid T=4 icosahedral viral capsid host intracellular membrane-bounded organelle host cell nucleus host intracellular organelle
J [auth Q], L [auth R], N [auth S], P [auth T]	Glycoprotein E2	peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity RNA binding binding nucleic acid binding structural molecule activity	viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell biological process involved in interspecies interaction between organisms symbiont entry into host cell symbiont entry into host viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction symbiont-mediated suppression of host signal transduction pathway symbiont-mediated perturbation of host cellular process symbiont-mediated perturbation of host process symbiont-mediated suppression of host toll-like receptor signaling pathway symbiont-mediated perturbation of host signal transduction pathway viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell biological process involved in interspecies interaction between organisms symbiont entry into host cell symbiont entry into host viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction symbiont-mediated suppression of host signal transduction pathway symbiont-mediated perturbation of host cellular process symbiont-mediated perturbation of host process symbiont-mediated suppression of host toll-like receptor signaling pathway symbiont-mediated perturbation of host signal transduction pathway modulation of process of another organism virion attachment to host cell adhesion of symbiont to host cell adhesion of symbiont to host proteolysis metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process	cellular anatomical structure membrane host cell plasma membrane host cellular component host cell part host cell membrane host intracellular part host cell cytoplasm host intracellular region virion component virion membrane viral capsid icosahedral viral capsid T=4 icosahedral viral capsid cellular anatomical structure membrane host cell plasma membrane host cellular component host cell part host cell membrane host intracellular part host cell cytoplasm host intracellular region virion component virion membrane viral capsid icosahedral viral capsid T=4 icosahedral viral capsid host intracellular membrane-bounded organelle host cell nucleus host intracellular organelle
Q [auth I], R [auth J], S [auth K], T [auth L]	Capsid protein	peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity RNA binding binding nucleic acid binding structural molecule activity	viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell biological process involved in interspecies interaction between organisms symbiont entry into host cell symbiont entry into host viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction symbiont-mediated suppression of host signal transduction pathway symbiont-mediated perturbation of host cellular process symbiont-mediated perturbation of host process symbiont-mediated suppression of host toll-like receptor signaling pathway symbiont-mediated perturbation of host signal transduction pathway viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell biological process involved in interspecies interaction between organisms symbiont entry into host cell symbiont entry into host viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction symbiont-mediated suppression of host signal transduction pathway symbiont-mediated perturbation of host cellular process symbiont-mediated perturbation of host process symbiont-mediated suppression of host toll-like receptor signaling pathway symbiont-mediated perturbation of host signal transduction pathway modulation of process of another organism virion attachment to host cell adhesion of symbiont to host cell adhesion of symbiont to host proteolysis metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process	cellular anatomical structure membrane host cell plasma membrane host cellular component host cell part host cell membrane host intracellular part host cell cytoplasm host intracellular region virion component virion membrane viral capsid icosahedral viral capsid T=4 icosahedral viral capsid cellular anatomical structure membrane host cell plasma membrane host cellular component host cell part host cell membrane host intracellular part host cell cytoplasm host intracellular region virion component virion membrane viral capsid icosahedral viral capsid T=4 icosahedral viral capsid host intracellular membrane-bounded organelle host cell nucleus host intracellular organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C [auth B], E [auth C], G [auth D]	IPR002533	Alphavirus E3 spike glycoprotein	Domain
A, C [auth B], E [auth C], G [auth D]	IPR038055	Flaviviral glycoprotein E, dimerisation domain	Homologous Superfamily
A, C [auth B], E [auth C], G [auth D]	IPR014756	Immunoglobulin E-set	Homologous Superfamily
A, C [auth B], E [auth C], G [auth D]	IPR042304	Alphavirus E2 glycoprotein, domain A	Homologous Superfamily
A, C [auth B], E [auth C], G [auth D]	IPR036253	Flavivirus glycoprotein, central and dimerisation domain superfamily	Homologous Superfamily
A, C [auth B], E [auth C], G [auth D]	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
A, C [auth B], E [auth C], G [auth D]	IPR042305	Alphavirus E2 glycoprotein, domain B	Homologous Superfamily
A, C [auth B], E [auth C], G [auth D]	IPR042306	Alphavirus E2 glycoprotein, domain C	Homologous Superfamily
A, C [auth B], E [auth C], G [auth D]	IPR000936	Alphavirus E2 glycoprotein	Family
A, C [auth B], E [auth C], G [auth D]	IPR000930	Peptidase S3, togavirin	Domain
A, C [auth B], E [auth C], G [auth D]	IPR002548	Alphavirus E1 glycoprotein	Domain
A, C [auth B], E [auth C], G [auth D]	IPR000336	Flavivirus/Alphavirus glycoprotein, immunoglobulin-like domain superfamily	Homologous Superfamily
A, C [auth B], E [auth C], G [auth D]	IPR043504	Peptidase S1, PA clan, chymotrypsin-like fold	Homologous Superfamily
B [auth M], D [auth N], F [auth O]	IPR002533	Alphavirus E3 spike glycoprotein	Domain
B [auth M], D [auth N], F [auth O]	IPR038055	Flaviviral glycoprotein E, dimerisation domain	Homologous Superfamily
B [auth M], D [auth N], F [auth O]	IPR014756	Immunoglobulin E-set	Homologous Superfamily
B [auth M], D [auth N], F [auth O]	IPR042304	Alphavirus E2 glycoprotein, domain A	Homologous Superfamily
B [auth M], D [auth N], F [auth O]	IPR036253	Flavivirus glycoprotein, central and dimerisation domain superfamily	Homologous Superfamily
B [auth M], D [auth N], F [auth O]	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
B [auth M], D [auth N], F [auth O]	IPR042305	Alphavirus E2 glycoprotein, domain B	Homologous Superfamily
B [auth M], D [auth N], F [auth O]	IPR042306	Alphavirus E2 glycoprotein, domain C	Homologous Superfamily
B [auth M], D [auth N], F [auth O]	IPR000936	Alphavirus E2 glycoprotein	Family
B [auth M], D [auth N], F [auth O]	IPR000930	Peptidase S3, togavirin	Domain
B [auth M], D [auth N], F [auth O]	IPR002548	Alphavirus E1 glycoprotein	Domain
B [auth M], D [auth N], F [auth O]	IPR000336	Flavivirus/Alphavirus glycoprotein, immunoglobulin-like domain superfamily	Homologous Superfamily
B [auth M], D [auth N], F [auth O]	IPR043504	Peptidase S1, PA clan, chymotrypsin-like fold	Homologous Superfamily
H [auth P]	IPR002533	Alphavirus E3 spike glycoprotein	Domain
H [auth P]	IPR038055	Flaviviral glycoprotein E, dimerisation domain	Homologous Superfamily
H [auth P]	IPR014756	Immunoglobulin E-set	Homologous Superfamily
H [auth P]	IPR042304	Alphavirus E2 glycoprotein, domain A	Homologous Superfamily
H [auth P]	IPR036253	Flavivirus glycoprotein, central and dimerisation domain superfamily	Homologous Superfamily
H [auth P]	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
H [auth P]	IPR042305	Alphavirus E2 glycoprotein, domain B	Homologous Superfamily
H [auth P]	IPR042306	Alphavirus E2 glycoprotein, domain C	Homologous Superfamily
H [auth P]	IPR000936	Alphavirus E2 glycoprotein	Family
H [auth P]	IPR000930	Peptidase S3, togavirin	Domain
H [auth P]	IPR002548	Alphavirus E1 glycoprotein	Domain
H [auth P]	IPR000336	Flavivirus/Alphavirus glycoprotein, immunoglobulin-like domain superfamily	Homologous Superfamily
H [auth P]	IPR043504	Peptidase S1, PA clan, chymotrypsin-like fold	Homologous Superfamily
I [auth E], K [auth F], M [auth G], O [auth H]	IPR002533	Alphavirus E3 spike glycoprotein	Domain
I [auth E], K [auth F], M [auth G], O [auth H]	IPR038055	Flaviviral glycoprotein E, dimerisation domain	Homologous Superfamily
I [auth E], K [auth F], M [auth G], O [auth H]	IPR014756	Immunoglobulin E-set	Homologous Superfamily
I [auth E], K [auth F], M [auth G], O [auth H]	IPR042304	Alphavirus E2 glycoprotein, domain A	Homologous Superfamily
I [auth E], K [auth F], M [auth G], O [auth H]	IPR036253	Flavivirus glycoprotein, central and dimerisation domain superfamily	Homologous Superfamily
I [auth E], K [auth F], M [auth G], O [auth H]	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
I [auth E], K [auth F], M [auth G], O [auth H]	IPR042305	Alphavirus E2 glycoprotein, domain B	Homologous Superfamily
I [auth E], K [auth F], M [auth G], O [auth H]	IPR042306	Alphavirus E2 glycoprotein, domain C	Homologous Superfamily
I [auth E], K [auth F], M [auth G], O [auth H]	IPR000936	Alphavirus E2 glycoprotein	Family
I [auth E], K [auth F], M [auth G], O [auth H]	IPR000930	Peptidase S3, togavirin	Domain
I [auth E], K [auth F], M [auth G], O [auth H]	IPR002548	Alphavirus E1 glycoprotein	Domain
I [auth E], K [auth F], M [auth G], O [auth H]	IPR000336	Flavivirus/Alphavirus glycoprotein, immunoglobulin-like domain superfamily	Homologous Superfamily
I [auth E], K [auth F], M [auth G], O [auth H]	IPR043504	Peptidase S1, PA clan, chymotrypsin-like fold	Homologous Superfamily
J [auth Q], L [auth R], N [auth S], P [auth T]	IPR002533	Alphavirus E3 spike glycoprotein	Domain
J [auth Q], L [auth R], N [auth S], P [auth T]	IPR038055	Flaviviral glycoprotein E, dimerisation domain	Homologous Superfamily
J [auth Q], L [auth R], N [auth S], P [auth T]	IPR014756	Immunoglobulin E-set	Homologous Superfamily
J [auth Q], L [auth R], N [auth S], P [auth T]	IPR042304	Alphavirus E2 glycoprotein, domain A	Homologous Superfamily
J [auth Q], L [auth R], N [auth S], P [auth T]	IPR036253	Flavivirus glycoprotein, central and dimerisation domain superfamily	Homologous Superfamily
J [auth Q], L [auth R], N [auth S], P [auth T]	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
J [auth Q], L [auth R], N [auth S], P [auth T]	IPR042305	Alphavirus E2 glycoprotein, domain B	Homologous Superfamily
J [auth Q], L [auth R], N [auth S], P [auth T]	IPR042306	Alphavirus E2 glycoprotein, domain C	Homologous Superfamily
J [auth Q], L [auth R], N [auth S], P [auth T]	IPR000936	Alphavirus E2 glycoprotein	Family
J [auth Q], L [auth R], N [auth S], P [auth T]	IPR000930	Peptidase S3, togavirin	Domain
J [auth Q], L [auth R], N [auth S], P [auth T]	IPR002548	Alphavirus E1 glycoprotein	Domain
J [auth Q], L [auth R], N [auth S], P [auth T]	IPR000336	Flavivirus/Alphavirus glycoprotein, immunoglobulin-like domain superfamily	Homologous Superfamily
J [auth Q], L [auth R], N [auth S], P [auth T]	IPR043504	Peptidase S1, PA clan, chymotrypsin-like fold	Homologous Superfamily
Q [auth I], R [auth J], S [auth K], T [auth L]	IPR002533	Alphavirus E3 spike glycoprotein	Domain
Q [auth I], R [auth J], S [auth K], T [auth L]	IPR038055	Flaviviral glycoprotein E, dimerisation domain	Homologous Superfamily
Q [auth I], R [auth J], S [auth K], T [auth L]	IPR014756	Immunoglobulin E-set	Homologous Superfamily
Q [auth I], R [auth J], S [auth K], T [auth L]	IPR042304	Alphavirus E2 glycoprotein, domain A	Homologous Superfamily
Q [auth I], R [auth J], S [auth K], T [auth L]	IPR036253	Flavivirus glycoprotein, central and dimerisation domain superfamily	Homologous Superfamily
Q [auth I], R [auth J], S [auth K], T [auth L]	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
Q [auth I], R [auth J], S [auth K], T [auth L]	IPR042305	Alphavirus E2 glycoprotein, domain B	Homologous Superfamily
Q [auth I], R [auth J], S [auth K], T [auth L]	IPR042306	Alphavirus E2 glycoprotein, domain C	Homologous Superfamily
Q [auth I], R [auth J], S [auth K], T [auth L]	IPR000936	Alphavirus E2 glycoprotein	Family
Q [auth I], R [auth J], S [auth K], T [auth L]	IPR000930	Peptidase S3, togavirin	Domain
Q [auth I], R [auth J], S [auth K], T [auth L]	IPR002548	Alphavirus E1 glycoprotein	Domain
Q [auth I], R [auth J], S [auth K], T [auth L]	IPR000336	Flavivirus/Alphavirus glycoprotein, immunoglobulin-like domain superfamily	Homologous Superfamily
Q [auth I], R [auth J], S [auth K], T [auth L]	IPR043504	Peptidase S1, PA clan, chymotrypsin-like fold	Homologous Superfamily

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B [auth M], C [auth B], D [auth N], E [auth C] A, B [auth M], C [auth B], D [auth N], E [auth C], F [auth O], G [auth D], H [auth P], I [auth E], J [auth Q], K [auth F], L [auth R], M [auth G], N [auth S], O [auth H], P [auth T], Q [auth I], R [auth J], S [auth K], T [auth L]	OPM	Transmembrane	Bitopic proteins	Viral membrane fusion glycoprotein	Alphavirus E1 glycoprotein