3MTH

X-RAY CRYSTALLOGRAPHIC STUDIES ON HEXAMERIC INSULINS IN THE PRESENCE OF HELIX-STABILIZING AGENTS, THIOCYANATE, METHYLPARABEN AND PHENOL

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d3mth.1	Small proteins	Insulin-like	Insulin-like	Insulin-like	Insulin	(Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)
D	d3mth.2	Small proteins	Insulin-like	Insulin-like	Insulin-like	Insulin	(Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)
A	d3mth.1	Small proteins	Insulin-like	Insulin-like	Insulin-like	Insulin	(Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)
C	d3mth.2	Small proteins	Insulin-like	Insulin-like	Insulin-like	Insulin	(Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Insulin-like	8038097	3000307	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Insulin-like	8038097	3000307	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Insulin-like	8038097	3000307	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Insulin-like	8038097	3000307	SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B, D	PF00049	Insulin/IGF/Relaxin family (Insulin)	Insulin/IGF/Relaxin family	Superfamily includes insulins; relaxins; insulin-like growth factor; and bombyxin. All are secreted regulatory hormones. Disulfide rich, all-alpha fold. Alignment includes B chain, linker (which is processed out of the final product), and A chain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B, D	METHYLPARABEN INSULIN	hormone activity protein binding binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity identical protein binding insulin-like growth factor receptor binding	biosynthetic process lipoprotein biosynthetic process lipoprotein metabolic process metabolic process cellular process primary metabolic process macromolecule metabolic process protein metabolic process macromolecule biosynthetic process lipid biosynthetic process lipid metabolic process lactate biosynthetic process monocarboxylic acid biosynthetic process small molecule biosynthetic process biosynthetic process lipoprotein biosynthetic process lipoprotein metabolic process metabolic process cellular process primary metabolic process macromolecule metabolic process protein metabolic process macromolecule biosynthetic process lipid biosynthetic process lipid metabolic process lactate biosynthetic process monocarboxylic acid biosynthetic process small molecule biosynthetic process oxoacid metabolic process organic hydroxy compound metabolic process carboxylic acid metabolic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process lactate metabolic process organic hydroxy compound biosynthetic process small molecule metabolic process monocarboxylic acid metabolic process regulation of cellular process positive regulation of DNA replication positive regulation of biological process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of cellular process positive regulation of nucleobase-containing compound metabolic process regulation of biological process biological regulation DNA metabolic process regulation of macromolecule metabolic process nucleic acid metabolic process DNA replication positive regulation of DNA metabolic process regulation of metabolic process regulation of DNA metabolic process regulation of DNA replication ketone metabolic process regulation of lipid metabolic process positive regulation of fatty acid biosynthetic process regulation of small molecule metabolic process positive regulation of biosynthetic process positive regulation of lipid metabolic process positive regulation of fatty acid metabolic process regulation of biosynthetic process fatty acid metabolic process fatty acid biosynthetic process regulation of ketone metabolic process positive regulation of lipid biosynthetic process regulation of fatty acid metabolic process regulation of fatty acid biosynthetic process regulation of lipid biosynthetic process positive regulation of small molecule metabolic process monosaccharide metabolic process carbohydrate metabolic process hexose metabolic process positive regulation of glucose metabolic process positive regulation of carbohydrate metabolic process regulation of carbohydrate metabolic process regulation of glucose metabolic process glucose metabolic process carbohydrate derivative biosynthetic process glycoprotein biosynthetic process carbohydrate derivative metabolic process glycoprotein metabolic process regulation of catalytic activity positive regulation of catalytic activity positive regulation of lipoprotein lipase activity regulation of lipoprotein lipase activity positive regulation of lipase activity positive regulation of triglyceride lipase activity regulation of molecular function positive regulation of molecular function positive regulation of hydrolase activity regulation of hydrolase activity regulation of lipase activity cellular response to nitrogen compound cellular response to stimulus positive regulation of cell communication positive regulation of signal transduction response to stimulus signaling response to peptide hormone regulation of signal transduction insulin receptor signaling pathway regulation of cellular response to insulin stimulus cell surface receptor protein tyrosine kinase signaling pathway cell communication positive regulation of response to stimulus cellular response to endogenous stimulus response to hormone signal transduction enzyme-linked receptor protein signaling pathway cellular response to hormone stimulus positive regulation of cellular response to insulin stimulus regulation of signaling cell surface receptor signaling pathway response to endogenous stimulus regulation of insulin receptor signaling pathway positive regulation of insulin receptor signaling pathway response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to chemical stimulus regulation of response to stimulus response to chemical response to insulin regulation of cell communication cellular response to insulin stimulus positive regulation of signaling protein localization regulation of localization establishment of protein localization cellular localization nitrogen compound transport regulation of protein localization transport positive regulation of establishment of protein localization positive regulation of secretion by cell protein localization to extracellular region positive regulation of protein transport localization regulation of secretion by cell secretion by cell positive regulation of secretion cellular macromolecule localization regulation of transport secretion regulation of establishment of protein localization establishment of protein localization to extracellular region export from cell regulation of protein transport protein secretion establishment of localization positive regulation of protein secretion regulation of protein secretion regulation of secretion positive regulation of transport protein transport regulation of cellular localization macromolecule localization positive regulation of protein localization positive regulation of locomotion regulation of cell motility positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration cell motility locomotion negative regulation of small molecule metabolic process negative regulation of biological process gluconeogenesis negative regulation of gluconeogenesis negative regulation of cellular process negative regulation of carbohydrate metabolic process negative regulation of metabolic process carbohydrate biosynthetic process monosaccharide biosynthetic process hexose biosynthetic process negative regulation of biosynthetic process regulation of gluconeogenesis regulation of carbohydrate biosynthetic process response to acid chemical response to L-arginine response to amino acid chemical homeostasis homeostatic process glucose homeostasis carbohydrate homeostasis positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of phosphate metabolic process positive regulation of protein modification process regulation of phosphate metabolic process phosphate-containing compound metabolic process positive regulation of protein phosphorylation phosphorus metabolic process protein modification process protein phosphorylation positive regulation of phosphorus metabolic process protein autophosphorylation phosphorylation regulation of protein metabolic process regulation of protein autophosphorylation macromolecule modification regulation of phosphorus metabolic process regulation of phosphorylation positive regulation of protein autophosphorylation	cellular anatomical structure extracellular region extracellular space
A, C	METHYLPARABEN INSULIN	hormone activity protein binding binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity identical protein binding insulin-like growth factor receptor binding	biosynthetic process lipoprotein biosynthetic process lipoprotein metabolic process metabolic process cellular process primary metabolic process macromolecule metabolic process protein metabolic process macromolecule biosynthetic process lipid biosynthetic process lipid metabolic process lactate biosynthetic process monocarboxylic acid biosynthetic process small molecule biosynthetic process biosynthetic process lipoprotein biosynthetic process lipoprotein metabolic process metabolic process cellular process primary metabolic process macromolecule metabolic process protein metabolic process macromolecule biosynthetic process lipid biosynthetic process lipid metabolic process lactate biosynthetic process monocarboxylic acid biosynthetic process small molecule biosynthetic process oxoacid metabolic process organic hydroxy compound metabolic process carboxylic acid metabolic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process lactate metabolic process organic hydroxy compound biosynthetic process small molecule metabolic process monocarboxylic acid metabolic process regulation of cellular process positive regulation of DNA replication positive regulation of biological process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of cellular process positive regulation of nucleobase-containing compound metabolic process regulation of biological process biological regulation DNA metabolic process regulation of macromolecule metabolic process nucleic acid metabolic process DNA replication positive regulation of DNA metabolic process regulation of metabolic process regulation of DNA metabolic process regulation of DNA replication ketone metabolic process regulation of lipid metabolic process positive regulation of fatty acid biosynthetic process regulation of small molecule metabolic process positive regulation of biosynthetic process positive regulation of lipid metabolic process positive regulation of fatty acid metabolic process regulation of biosynthetic process fatty acid metabolic process fatty acid biosynthetic process regulation of ketone metabolic process positive regulation of lipid biosynthetic process regulation of fatty acid metabolic process regulation of fatty acid biosynthetic process regulation of lipid biosynthetic process positive regulation of small molecule metabolic process monosaccharide metabolic process carbohydrate metabolic process hexose metabolic process positive regulation of glucose metabolic process positive regulation of carbohydrate metabolic process regulation of carbohydrate metabolic process regulation of glucose metabolic process glucose metabolic process carbohydrate derivative biosynthetic process glycoprotein biosynthetic process carbohydrate derivative metabolic process glycoprotein metabolic process regulation of catalytic activity positive regulation of catalytic activity positive regulation of lipoprotein lipase activity regulation of lipoprotein lipase activity positive regulation of lipase activity positive regulation of triglyceride lipase activity regulation of molecular function positive regulation of molecular function positive regulation of hydrolase activity regulation of hydrolase activity regulation of lipase activity cellular response to nitrogen compound cellular response to stimulus positive regulation of cell communication positive regulation of signal transduction response to stimulus signaling response to peptide hormone regulation of signal transduction insulin receptor signaling pathway regulation of cellular response to insulin stimulus cell surface receptor protein tyrosine kinase signaling pathway cell communication positive regulation of response to stimulus cellular response to endogenous stimulus response to hormone signal transduction enzyme-linked receptor protein signaling pathway cellular response to hormone stimulus positive regulation of cellular response to insulin stimulus regulation of signaling cell surface receptor signaling pathway response to endogenous stimulus regulation of insulin receptor signaling pathway positive regulation of insulin receptor signaling pathway response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to chemical stimulus regulation of response to stimulus response to chemical response to insulin regulation of cell communication cellular response to insulin stimulus positive regulation of signaling protein localization regulation of localization establishment of protein localization cellular localization nitrogen compound transport regulation of protein localization transport positive regulation of establishment of protein localization positive regulation of secretion by cell protein localization to extracellular region positive regulation of protein transport localization regulation of secretion by cell secretion by cell positive regulation of secretion cellular macromolecule localization regulation of transport secretion regulation of establishment of protein localization establishment of protein localization to extracellular region export from cell regulation of protein transport protein secretion establishment of localization positive regulation of protein secretion regulation of protein secretion regulation of secretion positive regulation of transport protein transport regulation of cellular localization macromolecule localization positive regulation of protein localization positive regulation of locomotion regulation of cell motility positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration cell motility locomotion negative regulation of small molecule metabolic process negative regulation of biological process gluconeogenesis negative regulation of gluconeogenesis negative regulation of cellular process negative regulation of carbohydrate metabolic process negative regulation of metabolic process carbohydrate biosynthetic process monosaccharide biosynthetic process hexose biosynthetic process negative regulation of biosynthetic process regulation of gluconeogenesis regulation of carbohydrate biosynthetic process response to acid chemical response to L-arginine response to amino acid chemical homeostasis homeostatic process glucose homeostasis carbohydrate homeostasis positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of phosphate metabolic process positive regulation of protein modification process regulation of phosphate metabolic process phosphate-containing compound metabolic process positive regulation of protein phosphorylation phosphorus metabolic process protein modification process protein phosphorylation positive regulation of phosphorus metabolic process protein autophosphorylation phosphorylation regulation of protein metabolic process regulation of protein autophosphorylation macromolecule modification regulation of phosphorus metabolic process regulation of phosphorylation positive regulation of protein autophosphorylation	cellular anatomical structure extracellular region extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B, D	IPR022352	Insulin family	Family
B, D	IPR004825	Insulin	Family
B, D	IPR016179	Insulin-like	Domain
B, D	IPR022353	Insulin, conserved site	Conserved Site
B, D	IPR036438	Insulin-like superfamily	Homologous Superfamily
A, C	IPR022352	Insulin family	Family
A, C	IPR004825	Insulin	Family
A, C	IPR016179	Insulin-like	Domain
A, C	IPR022353	Insulin, conserved site	Conserved Site
A, C	IPR036438	Insulin-like superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.