Annotations: 3P8F

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Trypsin-like serine proteases	8035635	3000114	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Trypsin_1	e3p8fA1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel 2	F: Trypsin_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.40.10.10	Mainly Beta	Beta Barrel	Thrombin, subunit H	Trypsin-like serine proteases	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00089	Trypsin (Trypsin)	Trypsin	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B [auth I]	Trypsin inhibitor 1	protein binding binding enzyme binding protease binding enzyme regulator activity molecular function inhibitor activity peptidase regulator activity serine-type endopeptidase inhibitor activity molecular function regulator activity enzyme inhibitor activity peptidase inhibitor activity endopeptidase regulator activity endopeptidase inhibitor activity	negative regulation of hydrolase activity regulation of cellular process negative regulation of proteolysis regulation of catalytic activity negative regulation of biological process negative regulation of catalytic activity negative regulation of endopeptidase activity regulation of primary metabolic process negative regulation of peptidase activity regulation of proteolysis proteolysis regulation of endopeptidase activity negative regulation of cellular process protein metabolic process negative regulation of hydrolase activity regulation of cellular process negative regulation of proteolysis regulation of catalytic activity negative regulation of biological process negative regulation of catalytic activity negative regulation of endopeptidase activity regulation of primary metabolic process negative regulation of peptidase activity regulation of proteolysis proteolysis regulation of endopeptidase activity negative regulation of cellular process protein metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process regulation of biological process regulation of protein metabolic process negative regulation of metabolic process regulation of peptidase activity biological regulation negative regulation of molecular function primary metabolic process regulation of macromolecule metabolic process regulation of molecular function regulation of hydrolase activity metabolic process cellular process macromolecule metabolic process regulation of metabolic process	-
A	ST14 protein	peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity	multicellular organismal process embryonic epithelial tube formation chordate embryonic development tube formation embryo development multicellular organism development epithelial tube formation tube morphogenesis primary neural tube formation embryo development ending in birth or egg hatching anatomical structure development epithelial tube morphogenesis system development developmental process multicellular organismal process embryonic epithelial tube formation chordate embryonic development tube formation embryo development multicellular organism development epithelial tube formation tube morphogenesis primary neural tube formation embryo development ending in birth or egg hatching anatomical structure development epithelial tube morphogenesis system development developmental process morphogenesis of embryonic epithelium epithelium development neural tube development tube development embryonic morphogenesis morphogenesis of an epithelium nervous system development tissue development anatomical structure morphogenesis tissue morphogenesis neural tube closure neural tube formation anatomical structure formation involved in morphogenesis tube closure epidermal cell differentiation cellular developmental process epidermis development animal organ development epithelial cell differentiation skin development cell differentiation keratinocyte differentiation cellular process catabolic process metabolic process primary metabolic process protein catabolic process protein metabolic process macromolecule metabolic process macromolecule catabolic process cell differentiation involved in embryonic placenta development epithelial cell differentiation involved in embryonic placenta development reproductive process cell development labyrinthine layer development developmental process involved in reproduction cell morphogenesis embryonic placenta development epithelial cell morphogenesis epithelial cell morphogenesis involved in placental branching embryonic organ development placenta development branching involved in labyrinthine layer morphogenesis in utero embryonic development embryonic placenta morphogenesis labyrinthine layer morphogenesis epithelial cell development morphogenesis of a branching structure morphogenesis of a branching epithelium proteolysis	cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane basal part of cell basal plasma membrane plasma membrane region basolateral plasma membrane extracellular region extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR002172	Low-density lipoprotein (LDL) receptor class A repeat	Repeat
A	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
A	IPR017051	Peptidase S1A, matripase	Family
A	IPR033116	Serine proteases, trypsin family, serine active site	Active Site
A	IPR035914	Spermadhesin, CUB domain superfamily	Homologous Superfamily
A	IPR001254	Serine proteases, trypsin domain	Domain
A	IPR023415	Low-density lipoprotein (LDL) receptor class A, conserved site	Conserved Site
A	IPR036055	LDL receptor-like superfamily	Homologous Superfamily
A	IPR036364	SEA domain superfamily	Homologous Superfamily
A	IPR000859	CUB domain	Domain
A	IPR000082	SEA domain	Domain
A	IPR043504	Peptidase S1, PA clan, chymotrypsin-like fold	Homologous Superfamily
A	IPR018114	Serine proteases, trypsin family, histidine active site	Active Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9Y5Y6	autosomal recessive congenital ichthyosis 11 Netherton syndrome Liver Cirrhosis, Experimental prostate cancer cystic fibrosis ichthyosis linearis circumflexa malignant pancreatic neoplasm osteosarcoma pancreatic intraductal papillary-mucinous neoplasm psoriasis atopic eczema ductal breast carcinoma in situ interstitial cystitis lung adenocarcinoma pancreatic ductal adenocarcinoma autosomal recessive congenital ichthyosis 11 Netherton syndrome Liver Cirrhosis, Experimental prostate cancer cystic fibrosis ichthyosis linearis circumflexa malignant pancreatic neoplasm osteosarcoma pancreatic intraductal papillary-mucinous neoplasm psoriasis atopic eczema ductal breast carcinoma in situ interstitial cystitis lung adenocarcinoma pancreatic ductal adenocarcinoma hypotrichosis invasive ductal breast carcinoma lung cancer non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.