3R7G | pdb_00003r7g

Crystal structure of Spire KIND domain in complex with the tail of FMN2

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	KIND	e3r7gA1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: KIND	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.510.10	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF16474	Kinase non-catalytic C-lobe domain (KIND)	Kinase non-catalytic C-lobe domain	The KIND domain (kinase non-catalytic C-lobe domain) evolved from a catalytic protein kinase fold and functions as an interaction domain [1]. In SPIRE1 (protein spire homologue 1) this domain interacts with FMN2 (formin-2) [2-3].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Protein spire homolog 1	cytoskeletal protein binding microtubule binding protein binding binding tubulin binding actin binding	cellular response to stimulus regulation of cellular process response to stimulus regulation of double-strand break repair positive regulation of biological process regulation of cellular response to stress regulation of primary metabolic process positive regulation of response to stimulus nucleobase-containing compound metabolic process positive regulation of metabolic process positive regulation of DNA repair cellular response to stress response to stress regulation of response to stress cellular response to stimulus regulation of cellular process response to stimulus regulation of double-strand break repair positive regulation of biological process regulation of cellular response to stress regulation of primary metabolic process positive regulation of response to stimulus nucleobase-containing compound metabolic process positive regulation of metabolic process positive regulation of DNA repair cellular response to stress response to stress regulation of response to stress positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of cellular process DNA repair double-strand break repair regulation of biological process positive regulation of nucleobase-containing compound metabolic process biological regulation primary metabolic process DNA metabolic process regulation of macromolecule metabolic process positive regulation of double-strand break repair nucleic acid metabolic process regulation of DNA repair positive regulation of DNA metabolic process regulation of response to stimulus DNA damage response metabolic process cellular process macromolecule metabolic process regulation of metabolic process regulation of DNA metabolic process establishment of organelle localization cellular localization sexual reproduction reproductive process meiotic cell cycle microtubule cytoskeleton organization establishment of meiotic spindle localization spindle localization meiotic cell cycle process establishment of localization cellular component organization localization organelle organization establishment of spindle localization organelle localization establishment of localization in cell microtubule-based process cell cycle cellular component organization or biogenesis cytoskeleton organization cell cycle process membrane organization cytoskeleton-dependent cytokinesis cytokinesis cleavage furrow formation cytokinetic process membrane invagination cell division plasma membrane invagination organelle fission multicellular organismal reproductive process female gamete generation meiotic cytokinesis gamete generation nuclear division female meiotic nuclear division polar body extrusion after meiotic divisions meiotic nuclear division actin cytoskeleton organization actin filament organization actin filament-based process actin nucleation supramolecular fiber organization protein localization establishment of protein localization nitrogen compound transport transport protein transport cellular macromolecule localization macromolecule localization protein polymerization actin polymerization or depolymerization actin filament polymerization protein-containing complex organization cellular component biogenesis cellular component assembly protein-containing complex assembly biological process involved in interspecies interaction between organisms immune response response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus immune system process defense response to other organism innate immune response response to external biotic stimulus Golgi vesicle transport vesicle-mediated transport formin-nucleated actin cable assembly parallel actin filament bundle assembly actin filament bundle organization formin-nucleated actin cable organization actin filament bundle assembly intracellular transport positive regulation of organelle organization regulation of cellular component organization positive regulation of cellular component organization regulation of developmental process positive regulation of developmental process anatomical structure development regulation of anatomical structure morphogenesis mitochondrion organization developmental process mitochondrial fission regulation of organelle organization anatomical structure morphogenesis regulation of mitochondrial fission regulation of mitochondrion organization positive regulation of mitochondrial fission actin filament network formation	cell periphery cell cortex cellular anatomical structure intracellular anatomical structure cytoplasm cytosol plasma membrane membrane membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cell periphery cell cortex cellular anatomical structure intracellular anatomical structure cytoplasm cytosol plasma membrane membrane membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen intracellular vesicle cytoplasmic vesicle membrane vesicle membrane cytoplasmic vesicle vesicle organelle membrane cytoskeleton membraneless organelle intracellular membraneless organelle perinuclear region of cytoplasm mitochondrial membrane mitochondrion organelle outer membrane organelle envelope bounding membrane of organelle mitochondrial envelope mitochondrial outer membrane outer membrane
B	Formin-2	cytoskeletal protein binding actin binding protein binding binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process regulation of cellular process regulation of double-strand break repair positive regulation of biological process regulation of cellular response to stress regulation of primary metabolic process positive regulation of response to stimulus nucleobase-containing compound metabolic process positive regulation of metabolic process cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process regulation of cellular process regulation of double-strand break repair positive regulation of biological process regulation of cellular response to stress regulation of primary metabolic process positive regulation of response to stimulus nucleobase-containing compound metabolic process positive regulation of metabolic process positive regulation of DNA repair regulation of response to stress positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of cellular process DNA repair double-strand break repair regulation of biological process positive regulation of nucleobase-containing compound metabolic process biological regulation primary metabolic process DNA metabolic process regulation of macromolecule metabolic process positive regulation of double-strand break repair nucleic acid metabolic process regulation of DNA repair positive regulation of DNA metabolic process regulation of response to stimulus metabolic process macromolecule metabolic process regulation of metabolic process regulation of DNA metabolic process establishment of organelle localization cellular localization sexual reproduction reproductive process meiotic cell cycle microtubule cytoskeleton organization establishment of meiotic spindle localization spindle localization meiotic cell cycle process establishment of localization cellular component organization localization organelle organization establishment of spindle localization organelle localization establishment of localization in cell microtubule-based process cell cycle cellular component organization or biogenesis cytoskeleton organization cell cycle process developmental process cellular developmental process oogenesis multicellular organismal reproductive process cell development cellular process involved in reproduction in multicellular organism developmental process involved in reproduction female gamete generation gamete generation cell differentiation anatomical structure development germ cell development cytoskeleton-dependent cytokinesis organelle fission cytokinesis meiotic cytokinesis nuclear division female meiotic nuclear division polar body extrusion after meiotic divisions meiotic nuclear division cell division meiotic chromosome segregation homologous chromosome movement towards spindle pole in meiosis I anaphase meiotic chromosome movement towards spindle pole meiosis I chromosome localization chromosome segregation chromosome movement towards spindle pole meiosis I cell cycle process nuclear chromosome segregation microtubule-based movement homologous chromosome segregation negative regulation of programmed cell death regulation of apoptotic process negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process apoptotic process programmed cell death response to decreased oxygen levels cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels cellular response to chemical stimulus response to hypoxia response to chemical response to oxygen levels response to abiotic stimulus protein localization establishment of protein localization nitrogen compound transport transport protein transport cellular macromolecule localization macromolecule localization actin cytoskeleton organization actin filament-based process cell migration cell motility formin-nucleated actin cable assembly actin filament organization cellular component biogenesis parallel actin filament bundle assembly cellular component assembly actin filament bundle organization formin-nucleated actin cable organization actin filament bundle assembly supramolecular fiber organization intracellular transport vesicle-mediated transport catabolic process macromolecule catabolic process negative regulation of protein catabolic process protein metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process negative regulation of catabolic process regulation of protein metabolic process negative regulation of metabolic process protein catabolic process regulation of catabolic process regulation of protein catabolic process signaling signal transduction intracellular signal transduction cell communication	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen cell periphery cell cortex cytoplasm cytosol plasma membrane membrane organelle subcompartment endomembrane system endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum organelle membrane endoplasmic reticulum membrane intracellular vesicle cytoplasmic vesicle membrane vesicle membrane cytoplasmic vesicle vesicle cell projection actin-based cell projection microvillus plasma membrane bounded cell projection perinuclear region of cytoplasm cytoskeleton spindle microtubule cytoskeleton

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR011011	Zinc finger, FYVE/PHD-type	Homologous Superfamily
A	IPR029901	Protein Spire	Family
A	IPR029905	Protein Spire homolog 1, FYVE-related domain	Domain
A	IPR011019	KIND domain	Domain
B	IPR042201	Formin, FH2 domain superfamily	Homologous Superfamily
B	IPR000591	DEP domain	Domain
B	IPR015425	Formin, FH2 domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q08AE8	adenoma large cell medulloblastoma osteosarcoma ulcerative colitis atypical teratoid rhabdoid tumor medulloblastoma ovarian cancer glioblastoma oligodendroglioma tuberculosis
B	Pharos: Q9NZ56	intellectual disability, autosomal recessive 47 renal cell carcinoma sarcomatoid renal cell carcinoma chromophobe renal cell carcinoma intellectual disability papillary renal cell carcinoma collecting duct carcinoma primitive neuroectodermal tumor Alzheimer disease Conventional (Clear Cell) Renal Cell Carcinoma lung carcinoma medulloblastoma renal carcinoma sinusitis astrocytic tumor intellectual disability, autosomal recessive 47 renal cell carcinoma sarcomatoid renal cell carcinoma chromophobe renal cell carcinoma intellectual disability papillary renal cell carcinoma collecting duct carcinoma primitive neuroectodermal tumor Alzheimer disease Conventional (Clear Cell) Renal Cell Carcinoma lung carcinoma medulloblastoma renal carcinoma sinusitis astrocytic tumor clear cell renal carcinoma cystic fibrosis malignant ependymoma oligodendroglioma pituitary cancer atypical teratoid rhabdoid tumor glioblastoma large cell medulloblastoma malignant glioma ovarian cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.