3R8D
Activation of the Human Nuclear Xenobiotic Receptor PXR by the Reverse Transcriptase-Targeted Anti-HIV Drug PNU-142721
External Resource: Annotation
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | d3r8da_ | All alpha proteins | Nuclear receptor ligand-binding domain | Nuclear receptor ligand-binding domain | Nuclear receptor ligand-binding domain | Pregnane x receptor, PXR | human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | Hormone_recep_1 | e3r8dA1 | A: alpha arrays | X: Nuclear receptor ligand-binding domain (From Topology) | H: Nuclear receptor ligand-binding domain (From Topology) | T: Nuclear receptor ligand-binding domain | F: Hormone_recep_1 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 1.10.565.10 | Mainly Alpha | Orthogonal Bundle | Retinoid X Receptor | Retinoid X Receptor | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF00104 | Ligand-binding domain of nuclear hormone receptor (Hormone_recep) | Ligand-binding domain of nuclear hormone receptor | This all helical domain is involved in binding the hormone in these receptors. | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR001628 | Zinc finger, nuclear hormone receptor-type | Domain | |
IPR050234 | Nuclear hormone receptor family NR1 subfamily | Family | |
IPR001723 | Nuclear hormone receptor | Family | |
IPR013088 | Zinc finger, NHR/GATA-type | Homologous Superfamily | |
IPR000536 | Nuclear hormone receptor, ligand-binding domain | Domain | |
IPR035500 | Nuclear hormone receptor-like domain superfamily | Homologous Superfamily |
Pharos: Disease Associations Pharos Homepage Annotation
Chains | Drug Target | Associated Disease |
---|---|---|
O75469 | :