Annotations: 3VH1

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	JAB1/MPN domain-like	8052657	3001105	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	JAB1/MPN domain-like	8052658	3001105	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	ThiF	e3vh1A1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: Activating enzymes of the ubiquitin-like proteins	F: ThiF	ECOD (1.6)
A	ATG7_N_1st	e3vh1A2	A: a/b three-layered sandwiches	X: Atg7 N-terminal domain-like	H: N-terminal domain in E1 enzyme Atg7 (From Topology)	T: N-terminal domain in E1 enzyme Atg7	F: ATG7_N_1st	ECOD (1.6)
A	KOG2337	e3vh1A3	A: a/b three-layered sandwiches	X: Atg7 N-terminal domain-like	H: N-terminal domain in E1 enzyme Atg7 (From Topology)	T: N-terminal domain in E1 enzyme Atg7	F: KOG2337	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00899	ThiF family (ThiF)	ThiF family	This domain is found in ubiquitin activating E1 family and members of the bacterial ThiF/MoeB/HesA family. It is repeated in Ubiquitin-activating enzyme E1 [1-3].	Domain
A	PF16420	Ubiquitin-like modifier-activating enzyme ATG7 N-terminus (ATG7_N)	Ubiquitin-like modifier-activating enzyme ATG7 N-terminus	This is the N-terminal domain of Ubiquitin-like modifier-activating enzyme ATG7. In Arabidopsis this domain binds the E2 enzymes ATG10 and ATG3 [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Ubiquitin-like modifier-activating enzyme ATG7	ubiquitin-like modifier activating enzyme activity ligase activity, forming carbon-sulfur bonds catalytic activity, acting on a protein catalytic activity Atg12 activating enzyme activity ligase activity ATP-dependent activity Atg8 activating enzyme activity identical protein binding protein binding binding	catabolic process macroautophagy autophagy cellular process metabolic process process utilizing autophagic mechanism autophagy of mitochondrion cellular response to stimulus response to nutrient levels cellular response to nitrogen levels response to stimulus cellular response to starvation cellular response to nutrient levels cellular response to stress catabolic process macroautophagy autophagy cellular process metabolic process process utilizing autophagic mechanism autophagy of mitochondrion cellular response to stimulus response to nutrient levels cellular response to nitrogen levels response to stimulus cellular response to starvation cellular response to nutrient levels cellular response to stress cellular response to nitrogen starvation response to stress response to starvation protein localization establishment of protein localization cellular localization nitrogen compound transport transport protein targeting establishment of protein localization to vacuole cytoplasm to vacuole targeting by the Cvt pathway localization cellular macromolecule localization establishment of localization in cell protein targeting to vacuole intracellular transport protein localization to vacuole establishment of localization establishment of protein localization to organelle protein transport macromolecule localization protein localization to organelle vacuolar transport intracellular protein transport piecemeal microautophagy of the nucleus microautophagy nucleophagy macromolecule modification primary metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle membrane cytosol extrinsic component of organelle membrane phagophore assembly site membrane extrinsic component of phagophore assembly site membrane phagophore assembly site membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle membrane cytosol extrinsic component of organelle membrane phagophore assembly site membrane extrinsic component of phagophore assembly site membrane phagophore assembly site extrinsic component of membrane organelle membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR042522	Ubiquitin-like modifier-activating enzyme Atg7, N-terminal, subdomain 1	Homologous Superfamily
A	IPR045886	ThiF/MoeB/HesA family	Family
A	IPR006285	Ubiquitin-like modifier-activating enzyme Atg7	Family
A	IPR000594	THIF-type NAD/FAD binding fold	Domain
A	IPR032197	Ubiquitin-like modifier-activating enzyme Atg7, N-terminal	Domain
A	IPR042523	Ubiquitin-like modifier-activating enzyme Atg7, N-terminal, subdomain 2	Homologous Superfamily
A	IPR035985	Ubiquitin-activating enzyme	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.