4AQ6
substrate bound homogentisate 1,2-dioxygenase
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
B | SCOP2B Superfamily | RmlC-like cupins | 8088133 | 3001825 | SCOP2B (2022-06-29) |
C | SCOP2B Superfamily | RmlC-like cupins | 8088133 | 3001825 | SCOP2B (2022-06-29) |
D | SCOP2B Superfamily | RmlC-like cupins | 8088133 | 3001825 | SCOP2B (2022-06-29) |
E | SCOP2B Superfamily | RmlC-like cupins | 8088133 | 3001825 | SCOP2B (2022-06-29) |
G | SCOP2B Superfamily | RmlC-like cupins | 8088133 | 3001825 | SCOP2B (2022-06-29) |
H | SCOP2B Superfamily | RmlC-like cupins | 8088133 | 3001825 | SCOP2B (2022-06-29) |
I | SCOP2B Superfamily | RmlC-like cupins | 8088133 | 3001825 | SCOP2B (2022-06-29) |
L | SCOP2B Superfamily | RmlC-like cupins | 8088133 | 3001825 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | RmlC-like cupins | 8088133 | 3001825 | SCOP2B (2022-06-29) |
F | SCOP2B Superfamily | RmlC-like cupins | 8088133 | 3001825 | SCOP2B (2022-06-29) |
J | SCOP2B Superfamily | RmlC-like cupins | 8088133 | 3001825 | SCOP2B (2022-06-29) |
K | SCOP2B Superfamily | RmlC-like cupins | 8088133 | 3001825 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
B | HgmA_2nd | e4aq6B3 | A: beta sandwiches | X: jelly-roll | H: Double-stranded beta-helix (From Topology) | T: Double-stranded beta-helix | F: HgmA_2nd | ECOD (1.6) |
B | HgmA_1st | e4aq6B2 | A: beta sandwiches | X: jelly-roll | H: Double-stranded beta-helix (From Topology) | T: Double-stranded beta-helix | F: HgmA_1st | ECOD (1.6) |
C | HgmA_2nd | e4aq6C3 | A: beta sandwiches | X: jelly-roll | H: Double-stranded beta-helix (From Topology) | T: Double-stranded beta-helix | F: HgmA_2nd | ECOD (1.6) |
C | HgmA_1st | e4aq6C2 | A: beta sandwiches | X: jelly-roll | H: Double-stranded beta-helix (From Topology) | T: Double-stranded beta-helix | F: HgmA_1st | ECOD (1.6) |
D | HgmA_2nd | e4aq6D3 | A: beta sandwiches | X: jelly-roll | H: Double-stranded beta-helix (From Topology) | T: Double-stranded beta-helix | F: HgmA_2nd | ECOD (1.6) |
D | HgmA_1st | e4aq6D2 | A: beta sandwiches | X: jelly-roll | H: Double-stranded beta-helix (From Topology) | T: Double-stranded beta-helix | F: HgmA_1st | ECOD (1.6) |
E | HgmA_2nd | e4aq6E3 | A: beta sandwiches | X: jelly-roll | H: Double-stranded beta-helix (From Topology) | T: Double-stranded beta-helix | F: HgmA_2nd | ECOD (1.6) |
E | HgmA_1st | e4aq6E2 | A: beta sandwiches | X: jelly-roll | H: Double-stranded beta-helix (From Topology) | T: Double-stranded beta-helix | F: HgmA_1st | ECOD (1.6) |
G | HgmA_2nd | e4aq6G3 | A: beta sandwiches | X: jelly-roll | H: Double-stranded beta-helix (From Topology) | T: Double-stranded beta-helix | F: HgmA_2nd | ECOD (1.6) |
G | HgmA_1st | e4aq6G2 | A: beta sandwiches | X: jelly-roll | H: Double-stranded beta-helix (From Topology) | T: Double-stranded beta-helix | F: HgmA_1st | ECOD (1.6) |
H | HgmA_2nd | e4aq6H3 | A: beta sandwiches | X: jelly-roll | H: Double-stranded beta-helix (From Topology) | T: Double-stranded beta-helix | F: HgmA_2nd | ECOD (1.6) |
H | HgmA_1st | e4aq6H2 | A: beta sandwiches | X: jelly-roll | H: Double-stranded beta-helix (From Topology) | T: Double-stranded beta-helix | F: HgmA_1st | ECOD (1.6) |
I | HgmA_2nd | e4aq6I3 | A: beta sandwiches | X: jelly-roll | H: Double-stranded beta-helix (From Topology) | T: Double-stranded beta-helix | F: HgmA_2nd | ECOD (1.6) |
I | HgmA_1st | e4aq6I2 | A: beta sandwiches | X: jelly-roll | H: Double-stranded beta-helix (From Topology) | T: Double-stranded beta-helix | F: HgmA_1st | ECOD (1.6) |
L | HgmA_2nd | e4aq6L3 | A: beta sandwiches | X: jelly-roll | H: Double-stranded beta-helix (From Topology) | T: Double-stranded beta-helix | F: HgmA_2nd | ECOD (1.6) |
L | HgmA_1st | e4aq6L2 | A: beta sandwiches | X: jelly-roll | H: Double-stranded beta-helix (From Topology) | T: Double-stranded beta-helix | F: HgmA_1st | ECOD (1.6) |
A | HgmA_2nd | e4aq6A3 | A: beta sandwiches | X: jelly-roll | H: Double-stranded beta-helix (From Topology) | T: Double-stranded beta-helix | F: HgmA_2nd | ECOD (1.6) |
A | HgmA_1st | e4aq6A2 | A: beta sandwiches | X: jelly-roll | H: Double-stranded beta-helix (From Topology) | T: Double-stranded beta-helix | F: HgmA_1st | ECOD (1.6) |
F | HgmA_2nd | e4aq6F3 | A: beta sandwiches | X: jelly-roll | H: Double-stranded beta-helix (From Topology) | T: Double-stranded beta-helix | F: HgmA_2nd | ECOD (1.6) |
F | HgmA_1st | e4aq6F2 | A: beta sandwiches | X: jelly-roll | H: Double-stranded beta-helix (From Topology) | T: Double-stranded beta-helix | F: HgmA_1st | ECOD (1.6) |
J | HgmA_2nd | e4aq6J3 | A: beta sandwiches | X: jelly-roll | H: Double-stranded beta-helix (From Topology) | T: Double-stranded beta-helix | F: HgmA_2nd | ECOD (1.6) |
J | HgmA_1st | e4aq6J2 | A: beta sandwiches | X: jelly-roll | H: Double-stranded beta-helix (From Topology) | T: Double-stranded beta-helix | F: HgmA_1st | ECOD (1.6) |
K | HgmA_2nd | e4aq6K3 | A: beta sandwiches | X: jelly-roll | H: Double-stranded beta-helix (From Topology) | T: Double-stranded beta-helix | F: HgmA_2nd | ECOD (1.6) |
K | HgmA_1st | e4aq6K2 | A: beta sandwiches | X: jelly-roll | H: Double-stranded beta-helix (From Topology) | T: Double-stranded beta-helix | F: HgmA_1st | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
B | 2.60.120.10 | Mainly Beta | Sandwich | Jelly Rolls | Jelly Rolls | CATH (4.3.0) |
C | 2.60.120.10 | Mainly Beta | Sandwich | Jelly Rolls | Jelly Rolls | CATH (4.3.0) |
D | 2.60.120.10 | Mainly Beta | Sandwich | Jelly Rolls | Jelly Rolls | CATH (4.3.0) |
E | 2.60.120.10 | Mainly Beta | Sandwich | Jelly Rolls | Jelly Rolls | CATH (4.3.0) |
G | 2.60.120.10 | Mainly Beta | Sandwich | Jelly Rolls | Jelly Rolls | CATH (4.3.0) |
H | 2.60.120.10 | Mainly Beta | Sandwich | Jelly Rolls | Jelly Rolls | CATH (4.3.0) |
I | 2.60.120.10 | Mainly Beta | Sandwich | Jelly Rolls | Jelly Rolls | CATH (4.3.0) |
L | 2.60.120.10 | Mainly Beta | Sandwich | Jelly Rolls | Jelly Rolls | CATH (4.3.0) |
A | 2.60.120.10 | Mainly Beta | Sandwich | Jelly Rolls | Jelly Rolls | CATH (4.3.0) |
F | 2.60.120.10 | Mainly Beta | Sandwich | Jelly Rolls | Jelly Rolls | CATH (4.3.0) |
J | 2.60.120.10 | Mainly Beta | Sandwich | Jelly Rolls | Jelly Rolls | CATH (4.3.0) |
K | 2.60.120.10 | Mainly Beta | Sandwich | Jelly Rolls | Jelly Rolls | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF04209 | Homogentisate 1,2-dioxygenase C-terminal (HgmA_C) | Homogentisate 1,2-dioxygenase C-terminal | Homogentisate dioxygenase cleaves the aromatic ring during the metabolic degradation of Phe and Tyr. Homogentisate dioxygenase deficiency causes alkaptonuria. The structure of homogentisate dioxygenase shows that the enzyme forms a hexamer arrangem ... | Domain | |
PF20510 | Homogentisate 1,2-dioxygenase N-terminal (HgmA_N) | Homogentisate 1,2-dioxygenase N-terminal | Homogentisate dioxygenase cleaves the aromatic ring during the metabolic degradation of Phe and Tyr. Homogentisate dioxygenase deficiency causes alkaptonuria. The structure of homogentisate dioxygenase shows that the enzyme forms a hexamer arrangem ... | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR022950 | Homogentisate 1,2-dioxygenase, bacterial | Family | |
IPR014710 | RmlC-like jelly roll fold | Homologous Superfamily | |
IPR046452 | Homogentisate 1,2-dioxygenase, N-terminal domain | Domain | |
IPR011051 | RmlC-like cupin domain superfamily | Homologous Superfamily | |
IPR046451 | Homogentisate 1,2-dioxygenase, C-terminal domain | Domain | |
IPR005708 | Homogentisate 1,2-dioxygenase | Family |