4DJH

Structure of the human kappa opioid receptor in complex with JDTic

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Lysozyme-like	8033861	3001879	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	G protein-coupled receptor-like	8091210	3000473	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	G protein-coupled receptor-like	8091210	3000473	SCOP2B (2022-06-29)
A	SCOP2 Family	Class A (rhodopsin) G protein-coupled receptor-like	8091209	4001858	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	G protein-coupled receptor-like	8091210	3000473	SCOP2 (2022-06-29)
A	SCOP2B Superfamily	Lysozyme-like	8033861	3001879	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	7tm_1_1	e4djhB4	A: alpha bundles	X: Family A G protein-coupled receptor-like (From Topology)	H: Family A G protein-coupled receptor-like (From Topology)	T: Family A G protein-coupled receptor-like	F: 7tm_1_1	ECOD (1.6)
B	Phage_lysozyme_2	e4djhB3	A: a+b complex topology	X: Lysozyme-like (From Homology)	H: Lysozyme-like	T: Lysozyme-like	F: Phage_lysozyme_2	ECOD (1.6)
A	7tm_1_1	e4djhA4	A: alpha bundles	X: Family A G protein-coupled receptor-like (From Topology)	H: Family A G protein-coupled receptor-like (From Topology)	T: Family A G protein-coupled receptor-like	F: 7tm_1_1	ECOD (1.6)
A	Phage_lysozyme_2	e4djhA3	A: a+b complex topology	X: Lysozyme-like (From Homology)	H: Lysozyme-like	T: Lysozyme-like	F: Phage_lysozyme_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	1.20.1070.10	Mainly Alpha	Up-down Bundle	Rhopdopsin 7-helix transmembrane proteins	Rhodopsin 7-helix transmembrane proteins	CATH (4.3.0)
B	1.10.530.40	Mainly Alpha	Orthogonal Bundle	Lysozyme		CATH (4.3.0)
A	1.20.1070.10	Mainly Alpha	Up-down Bundle	Rhopdopsin 7-helix transmembrane proteins	Rhodopsin 7-helix transmembrane proteins	CATH (4.3.0)
A	1.10.530.40	Mainly Alpha	Orthogonal Bundle	Lysozyme		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00959	Phage lysozyme (Phage_lysozyme)	Phage lysozyme	This family includes lambda phage lysozyme and E. coli endolysin.	Domain
A, B	PF00001	7 transmembrane receptor (rhodopsin family) (7tm_1)	7 transmembrane receptor (rhodopsin family)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Kappa-type opioid receptor, Lysozyme	binding neuropeptide binding peptide binding peptide receptor activity molecular transducer activity G protein-coupled opioid receptor activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity G protein-coupled peptide receptor activity dynorphin receptor activity protein binding receptor serine/threonine kinase binding signaling receptor binding binding neuropeptide binding peptide binding peptide receptor activity molecular transducer activity G protein-coupled opioid receptor activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity G protein-coupled peptide receptor activity dynorphin receptor activity protein binding receptor serine/threonine kinase binding signaling receptor binding hydrolase activity, acting on glycosyl bonds peptidoglycan muralytic activity hydrolase activity, hydrolyzing O-glycosyl compounds lysozyme activity hydrolase activity catalytic activity	ovulation cycle rhythmic process estrous cycle reproductive process multicellular organismal reproductive process cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation cell communication G protein-coupled opioid receptor signaling pathway G protein-coupled receptor signaling pathway ovulation cycle rhythmic process estrous cycle reproductive process multicellular organismal reproductive process cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation cell communication G protein-coupled opioid receptor signaling pathway G protein-coupled receptor signaling pathway cellular process signal transduction multicellular organismal process system process sensory perception nervous system process phospholipase C-activating G protein-coupled receptor signaling pathway trans-synaptic signaling synaptic signaling anterograde trans-synaptic signaling cell-cell signaling chemical synaptic transmission behavior learning learning or memory cognition conditioned place preference associative learning biological process involved in interspecies interaction between organisms response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus defense response to virus defense response to other organism response to stress response to external biotic stimulus response to virus response to acrylamide response to chemical response to oxygen-containing compound response to nitrogen compound neuropeptide signaling pathway locomotory behavior adult behavior response to alkaloid behavioral response to cocaine response to organic cyclic compound response to cocaine response to hormone response to endogenous stimulus response to estrogen immune response immune system process homeostatic process cellular response to glucose stimulus intracellular glucose homeostasis cellular response to oxygen-containing compound response to hexose cellular response to carbohydrate stimulus cellular response to chemical stimulus cellular homeostasis response to monosaccharide response to carbohydrate chemical homeostasis response to glucose glucose homeostasis carbohydrate homeostasis cellular response to hexose stimulus intracellular chemical homeostasis cellular response to monosaccharide stimulus maternal behavior parental behavior reproductive behavior regulation of localization negative regulation of luteinizing hormone secretion regulation of system process negative regulation of biological process negative regulation of transport localization regulation of luteinizing hormone secretion negative regulation of secretion luteinizing hormone secretion negative regulation of hormone secretion negative regulation of secretion by cell regulation of biological quality regulation of hormone levels establishment of localization regulation of secretion endocrine hormone secretion negative regulation of gonadotropin secretion negative regulation of multicellular organismal process regulation of endocrine process regulation of hormone secretion gonadotropin secretion transport negative regulation of signaling hormone secretion negative regulation of cell communication secretion by cell regulation of secretion by cell signal release negative regulation of cellular process regulation of multicellular organismal process regulation of signaling secretion regulation of transport regulation of gonadotropin secretion export from cell endocrine process hormone transport regulation of cell communication eating behavior feeding behavior sensory perception of temperature stimulus response to lipid cellular response to lipopolysaccharide cellular response to molecule of bacterial origin response to lipopolysaccharide cellular response to biotic stimulus response to bacterium cellular response to lipid response to molecule of bacterial origin adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway adenylate cyclase-inhibiting opioid receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway monoamine transport nitrogen compound transport regulation of catecholamine secretion positive regulation of biological process organic hydroxy compound transport positive regulation of secretion by cell dopamine transport positive regulation of amine transport catecholamine transport positive regulation of secretion positive regulation of cellular process positive regulation of catecholamine secretion dopamine secretion positive regulation of dopamine secretion catecholamine secretion amine transport positive regulation of transport regulation of amine transport regulation of dopamine secretion regulation of body fluid levels secretion by tissue digestive system process regulation of digestive system process body fluid secretion digestion saliva secretion regulation of saliva secretion response to alcohol response to ethanol response to peptide hormone response to insulin positive regulation of cell communication positive regulation of signal transduction regulation of signal transduction p38MAPK cascade intracellular signal transduction positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade positive regulation of p38MAPK cascade regulation of response to stimulus regulation of p38MAPK cascade MAPK cascade positive regulation of signaling regulation of eating behavior positive regulation of feeding behavior positive regulation of eating behavior regulation of behavior positive regulation of behavior positive regulation of multicellular organismal process regulation of feeding behavior sensory perception of pain response to nicotine positive regulation of cation transmembrane transport regulation of potassium ion transport monoatomic ion transmembrane transport potassium ion transmembrane transport regulation of monoatomic ion transmembrane transport metal ion transport monoatomic cation transmembrane transport positive regulation of monoatomic ion transport positive regulation of transmembrane transport monoatomic ion transport positive regulation of monoatomic ion transmembrane transport monoatomic cation transport regulation of metal ion transport regulation of monoatomic ion transport inorganic ion transmembrane transport regulation of potassium ion transmembrane transport inorganic cation transmembrane transport transmembrane transport positive regulation of potassium ion transport regulation of transmembrane transport positive regulation of potassium ion transmembrane transport potassium ion transport regulation of monoatomic cation transmembrane transport defense response to bacterium carbohydrate derivative catabolic process catabolic process peptidoglycan catabolic process glycosaminoglycan metabolic process carbohydrate derivative metabolic process aminoglycan catabolic process macromolecule catabolic process glycosaminoglycan catabolic process aminoglycan metabolic process peptidoglycan metabolic process metabolic process macromolecule metabolic process symbiont-mediated cytolysis of host cell viral life cycle disruption of cell in another organism cytolysis biological process involved in interaction with host biological process involved in symbiotic interaction viral release from host cell by cytolysis disruption of cellular anatomical structure in another organism exit from host cell viral process cytolysis in another organism viral release from host cell disruption of anatomical structure in another organism symbiont-mediated killing of host cell killing of cells of another organism cell killing disruption of plasma membrane integrity in another organism cell wall organization or biogenesis cell wall macromolecule catabolic process cell wall macromolecule metabolic process	cell periphery postsynapse cellular anatomical structure postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region synaptic membrane sarcolemma T-tubule somatodendritic compartment cell body cell periphery postsynapse cellular anatomical structure postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region synaptic membrane sarcolemma T-tubule somatodendritic compartment cell body perikaryon neuronal cell body intracellular anatomical structure cytoplasm cytosol presynapse presynaptic membrane cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection membrane-bounded organelle intracellular membrane-bounded organelle endomembrane system sarcoplasm intracellular organelle organelle endoplasmic reticulum sarcoplasmic reticulum intracellular vesicle transport vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane synaptic vesicle synaptic vesicle membrane vesicle transport vesicle exocytic vesicle membrane cytoplasmic vesicle membrane secretory vesicle organelle membrane exocytic vesicle mitochondrion nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen axon axon terminus distal axon neuron projection terminus host cellular component host intracellular part host cell cytoplasm host cell part host intracellular region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR001418	Opioid receptor	Family
A, B	IPR000276	G protein-coupled receptor, rhodopsin-like	Family
A, B	IPR000452	Kappa opioid receptor	Family
A, B	IPR017452	GPCR, rhodopsin-like, 7TM	Domain
A, B	IPR052619	Bacteriophage lysozyme-like	Family
A, B	IPR001165	T4-type lysozyme	Family
A, B	IPR034690	Endolysin T4 type	Family
A, B	IPR002196	Glycoside hydrolase, family 24	Family
A, B	IPR023347	Lysozyme domain superfamily	Homologous Superfamily
A, B	IPR023346	Lysozyme-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P41145	Pain opiate dependence cocaine dependence substance withdrawal syndrome visual epilepsy cocaine abuse pilocytic astrocytoma depressive disorder medulloblastoma obesity disorder pain agnosia schizophrenia glioblastoma malignant ependymoma atypical teratoid rhabdoid tumor Pain opiate dependence cocaine dependence substance withdrawal syndrome visual epilepsy cocaine abuse pilocytic astrocytoma depressive disorder medulloblastoma obesity disorder pain agnosia schizophrenia glioblastoma malignant ependymoma atypical teratoid rhabdoid tumor large cell medulloblastoma malignant glioma astrocytic tumor oligodendroglioma

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B	OPM	Transmembrane	Alpha-helical polytopic	Rhodopsin-like receptors and pumps	G-protein coupled receptors, family A

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	G Protein-Coupled Receptors: Class A	κ-opioid receptor in complex with JDTic

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.