4IQF

Crystal Structure of Methyionyl-tRNA Formyltransferase from Bacillus anthracis

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4iqfa2	All beta proteins	FMT C-terminal domain-like	FMT C-terminal domain-like	automated matches	automated matches	anthrax,anthrax bacterium (Bacillus anthracis ) [TaxId: 1392 ],	SCOPe (2.08)
A	d4iqfa1	Alpha and beta proteins (a/b)	Formyltransferase	Formyltransferase	automated matches	automated matches	anthrax,anthrax bacterium (Bacillus anthracis ) [TaxId: 1392 ],	SCOPe (2.08)
A	d4iqfa3	Artifacts	Tags	Tags	Tags	N-terminal Tags	anthrax,anthrax bacterium (Bacillus anthracis ) [TaxId: 1392 ],	SCOPe (2.08)
B	d4iqfb2	All beta proteins	FMT C-terminal domain-like	FMT C-terminal domain-like	automated matches	automated matches	anthrax,anthrax bacterium (Bacillus anthracis ) [TaxId: 1392 ],	SCOPe (2.08)
B	d4iqfb1	Alpha and beta proteins (a/b)	Formyltransferase	Formyltransferase	automated matches	automated matches	anthrax,anthrax bacterium (Bacillus anthracis ) [TaxId: 1392 ],	SCOPe (2.08)
B	d4iqfb3	Artifacts	Tags	Tags	Tags	N-terminal Tags	anthrax,anthrax bacterium (Bacillus anthracis ) [TaxId: 1392 ],	SCOPe (2.08)
D	d4iqfd2	All beta proteins	FMT C-terminal domain-like	FMT C-terminal domain-like	automated matches	automated matches	anthrax,anthrax bacterium (Bacillus anthracis ) [TaxId: 1392 ],	SCOPe (2.08)
D	d4iqfd1	Alpha and beta proteins (a/b)	Formyltransferase	Formyltransferase	automated matches	automated matches	anthrax,anthrax bacterium (Bacillus anthracis ) [TaxId: 1392 ],	SCOPe (2.08)
D	d4iqfd3	Artifacts	Tags	Tags	Tags	N-terminal Tags	anthrax,anthrax bacterium (Bacillus anthracis ) [TaxId: 1392 ],	SCOPe (2.08)
C	d4iqfc2	All beta proteins	FMT C-terminal domain-like	FMT C-terminal domain-like	automated matches	automated matches	anthrax,anthrax bacterium (Bacillus anthracis ) [TaxId: 1392 ],	SCOPe (2.08)
C	d4iqfc1	Alpha and beta proteins (a/b)	Formyltransferase	Formyltransferase	automated matches	automated matches	anthrax,anthrax bacterium (Bacillus anthracis ) [TaxId: 1392 ],	SCOPe (2.08)
C	d4iqfc3	Artifacts	Tags	Tags	Tags	N-terminal Tags	anthrax,anthrax bacterium (Bacillus anthracis ) [TaxId: 1392 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Formyl_trans_C	e4iqfA1	A: beta barrels	X: FMT C-terminal domain-like	H: FMT C-terminal domain-related (From Topology)	T: FMT C-terminal domain-related	F: Formyl_trans_C	ECOD (1.6)
A	Formyl_trans_N	e4iqfA2	A: a/b three-layered sandwiches	X: Formyltransferase (From Topology)	H: Formyltransferase (From Topology)	T: Formyltransferase	F: Formyl_trans_N	ECOD (1.6)
B	Formyl_trans_C	e4iqfB1	A: beta barrels	X: FMT C-terminal domain-like	H: FMT C-terminal domain-related (From Topology)	T: FMT C-terminal domain-related	F: Formyl_trans_C	ECOD (1.6)
B	Formyl_trans_N	e4iqfB2	A: a/b three-layered sandwiches	X: Formyltransferase (From Topology)	H: Formyltransferase (From Topology)	T: Formyltransferase	F: Formyl_trans_N	ECOD (1.6)
D	Formyl_trans_C	e4iqfD1	A: beta barrels	X: FMT C-terminal domain-like	H: FMT C-terminal domain-related (From Topology)	T: FMT C-terminal domain-related	F: Formyl_trans_C	ECOD (1.6)
D	Formyl_trans_N	e4iqfD2	A: a/b three-layered sandwiches	X: Formyltransferase (From Topology)	H: Formyltransferase (From Topology)	T: Formyltransferase	F: Formyl_trans_N	ECOD (1.6)
C	Formyl_trans_C	e4iqfC1	A: beta barrels	X: FMT C-terminal domain-like	H: FMT C-terminal domain-related (From Topology)	T: FMT C-terminal domain-related	F: Formyl_trans_C	ECOD (1.6)
C	Formyl_trans_N	e4iqfC2	A: a/b three-layered sandwiches	X: Formyltransferase (From Topology)	H: Formyltransferase (From Topology)	T: Formyltransferase	F: Formyl_trans_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.170	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Formyl transferase, N-terminal domain	CATH (4.3.0)
A	3.10.25.10	Alpha Beta	Roll	Methionyl-tRNA Fmet Formyltransferase	Chain A, domain 2	CATH (4.3.0)
B	3.40.50.170	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Formyl transferase, N-terminal domain	CATH (4.3.0)
B	3.10.25.10	Alpha Beta	Roll	Methionyl-tRNA Fmet Formyltransferase	Chain A, domain 2	CATH (4.3.0)
D	3.40.50.170	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Formyl transferase, N-terminal domain	CATH (4.3.0)
D	3.10.25.10	Alpha Beta	Roll	Methionyl-tRNA Fmet Formyltransferase	Chain A, domain 2	CATH (4.3.0)
C	3.40.50.170	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Formyl transferase, N-terminal domain	CATH (4.3.0)
C	3.10.25.10	Alpha Beta	Roll	Methionyl-tRNA Fmet Formyltransferase	Chain A, domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF02911	Formyl transferase, C-terminal domain (Formyl_trans_C)	Formyl transferase, C-terminal domain	-	Domain
A, B, C, D	PF00551	Formyl transferase (Formyl_trans_N)	Formyl transferase	This family includes the following members. Glycinamide ribonucleotide transformylase catalyses the third step in de novo purine biosynthesis, the transfer of a formyl group to 5'-phosphoribosylglycinamide. Formyltetrahydrofolate deformylase produces ...	This family includes the following members. Glycinamide ribonucleotide transformylase catalyses the third step in de novo purine biosynthesis, the transfer of a formyl group to 5'-phosphoribosylglycinamide. Formyltetrahydrofolate deformylase produces formate from formyl- tetrahydrofolate. Methionyl-tRNA formyltransferase transfers a formyl group onto the amino terminus of the acyl moiety of the methionyl aminoacyl-tRNA. Inclusion of the following members is supported by PSI-blast. HOXX_BRAJA (P31907) contains a related domain of unknown function. PRTH_PORGI (P46071) contains a related domain of unknown function. Y09P_MYCTU (Q50721) contains a related domain of unknown function.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Methionyl-tRNA formyltransferase	catalytic activity, acting on RNA methionyl-tRNA formyltransferase activity transferase activity, transferring one-carbon groups catalytic activity, acting on a nucleic acid catalytic activity, acting on a tRNA transferase activity hydroxymethyl-, formyl- and related transferase activity catalytic activity	-	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR037022	Formyl transferase, C-terminal domain superfamily	Homologous Superfamily
A, B, C, D	IPR001555	Phosphoribosylglycinamide formyltransferase, active site	Active Site
A, B, C, D	IPR044135	Methionyl-tRNA formyltransferase, C-terminal domain	Domain
A, B, C, D	IPR005794	Methionyl-tRNA formyltransferase	Family
A, B, C, D	IPR002376	Formyl transferase, N-terminal	Domain
A, B, C, D	IPR005793	Formyl transferase, C-terminal	Domain
A, B, C, D	IPR041711	Methionyl-tRNA formyltransferase, N-terminal domain	Domain
A, B, C, D	IPR036477	Formyl transferase, N-terminal domain superfamily	Homologous Superfamily
A, B, C, D	IPR011034	Formyl transferase-like, C-terminal domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.