4M2X
Mycobacterium tuberculosis dihydrofolate reductase complexed with trimetrexate (TMQ)
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
B [auth C] | d4m2xc_ | Alpha and beta proteins (a/b) | Dihydrofolate reductase-like | Dihydrofolate reductase-like | automated matches | automated matches | (Mycobacterium tuberculosis ) [TaxId: 1773 ], | SCOPe (2.08) |
A | d4m2xa_ | Alpha and beta proteins (a/b) | Dihydrofolate reductase-like | Dihydrofolate reductase-like | automated matches | automated matches | (Mycobacterium tuberculosis ) [TaxId: 1773 ], | SCOPe (2.08) |
C [auth E] | d4m2xe_ | Alpha and beta proteins (a/b) | Dihydrofolate reductase-like | Dihydrofolate reductase-like | automated matches | automated matches | (Mycobacterium tuberculosis ) [TaxId: 1773 ], | SCOPe (2.08) |
D [auth G] | d4m2xg_ | Alpha and beta proteins (a/b) | Dihydrofolate reductase-like | Dihydrofolate reductase-like | automated matches | automated matches | (Mycobacterium tuberculosis ) [TaxId: 1773 ], | SCOPe (2.08) |
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
B [auth C] | SCOP2B Superfamily | Dihydrofolate reductase-like | 8032720 | 3001255 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | Dihydrofolate reductase-like | 8032720 | 3001255 | SCOP2B (2022-06-29) |
C [auth E] | SCOP2B Superfamily | Dihydrofolate reductase-like | 8032720 | 3001255 | SCOP2B (2022-06-29) |
D [auth G] | SCOP2B Superfamily | Dihydrofolate reductase-like | 8032720 | 3001255 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
B [auth C] | DHFR_1 | e4m2xC1 | A: a/b three-layered sandwiches | X: Dihydrofolate reductases (From Topology) | H: Dihydrofolate reductases (From Topology) | T: Dihydrofolate reductases | F: DHFR_1 | ECOD (1.6) |
A | DHFR_1 | e4m2xA1 | A: a/b three-layered sandwiches | X: Dihydrofolate reductases (From Topology) | H: Dihydrofolate reductases (From Topology) | T: Dihydrofolate reductases | F: DHFR_1 | ECOD (1.6) |
C [auth E] | DHFR_1 | e4m2xE1 | A: a/b three-layered sandwiches | X: Dihydrofolate reductases (From Topology) | H: Dihydrofolate reductases (From Topology) | T: Dihydrofolate reductases | F: DHFR_1 | ECOD (1.6) |
D [auth G] | DHFR_1 | e4m2xG1 | A: a/b three-layered sandwiches | X: Dihydrofolate reductases (From Topology) | H: Dihydrofolate reductases (From Topology) | T: Dihydrofolate reductases | F: DHFR_1 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
B [auth C] | 3.40.430.10 | Alpha Beta | 3-Layer(aba) Sandwich | Dihydrofolate Reductase, subunit A | Dihydrofolate Reductase, subunit A | CATH (4.3.0) |
A | 3.40.430.10 | Alpha Beta | 3-Layer(aba) Sandwich | Dihydrofolate Reductase, subunit A | Dihydrofolate Reductase, subunit A | CATH (4.3.0) |
C [auth E] | 3.40.430.10 | Alpha Beta | 3-Layer(aba) Sandwich | Dihydrofolate Reductase, subunit A | Dihydrofolate Reductase, subunit A | CATH (4.3.0) |
D [auth G] | 3.40.430.10 | Alpha Beta | 3-Layer(aba) Sandwich | Dihydrofolate Reductase, subunit A | Dihydrofolate Reductase, subunit A | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
A, B [auth C], C [auth E], D [auth G] | PF00186 | Dihydrofolate reductase (DHFR_1) | Dihydrofolate reductase | - | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
A, B [auth C], C [auth E], D [auth G] | IPR024072 | Dihydrofolate reductase-like domain superfamily | Homologous Superfamily |
A, B [auth C], C [auth E], D [auth G] | IPR001796 | Dihydrofolate reductase domain | Domain |
A, B [auth C], C [auth E], D [auth G] | IPR017925 | Dihydrofolate reductase conserved site | Conserved Site |
A, B [auth C], C [auth E], D [auth G] | IPR012259 | Dihydrofolate reductase | Family |