Annotations: 4OEZ

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Nuclear receptor ligand-binding domain	8037208	3001442	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Hormone_recep_1	e4oezA1	A: alpha arrays	X: Nuclear receptor ligand-binding domain (From Topology)	H: Nuclear receptor ligand-binding domain (From Topology)	T: Nuclear receptor ligand-binding domain	F: Hormone_recep_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.565.10	Mainly Alpha	Orthogonal Bundle	Retinoid X Receptor	Retinoid X Receptor	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00104	Ligand-binding domain of nuclear hormone receptor (Hormone_recep)	Ligand-binding domain of nuclear hormone receptor	This all helical domain is involved in binding the hormone in these receptors.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B	co-regulator peptide	-	-	-
A	Androgen receptor	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding hormone binding androgen binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding hormone binding androgen binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding estrogen response element binding RNA polymerase II cis-regulatory region sequence-specific DNA binding nuclear receptor activity molecular transducer activity ligand-activated transcription factor activity signaling receptor activity molecular adaptor activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity ATPase binding protein binding enzyme binding signaling receptor binding POU domain binding protein domain specific binding G protein-coupled receptor activity transmembrane signaling receptor activity transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding chromatin binding molecular condensate scaffold activity protein-macromolecule adaptor activity basal transcription machinery binding basal RNA polymerase II transcription machinery binding general transcription initiation factor binding RNA polymerase II general transcription initiation factor binding transcription coregulator binding transcription coactivator binding steroid binding lipid binding beta-catenin binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	developmental process multicellular organismal process gonad development reproductive system development reproductive process sex differentiation animal organ development developmental process involved in reproduction male gonad development male sex differentiation multicellular organism development development of primary male sexual characteristics development of primary sexual characteristics anatomical structure development reproductive structure development developmental process multicellular organismal process gonad development reproductive system development reproductive process sex differentiation animal organ development developmental process involved in reproduction male gonad development male sex differentiation multicellular organism development development of primary male sexual characteristics development of primary sexual characteristics anatomical structure development reproductive structure development system development spermatogenesis sexual reproduction multicellular organismal reproductive process male gamete generation gamete generation epithelial cell differentiation involved in prostate gland development epithelium development cellular developmental process prostate gland development gland development urogenital system development tissue development epithelial cell differentiation cell differentiation cellular process branching involved in mammary gland duct morphogenesis multi-multicellular organism process mammary gland morphogenesis maternal process involved in female pregnancy mammary gland development branching morphogenesis of an epithelial tube tertiary branching involved in mammary gland duct morphogenesis tube morphogenesis gland morphogenesis mammary gland branching involved in pregnancy animal organ morphogenesis epithelial tube morphogenesis female pregnancy tube development morphogenesis of an epithelium mammary gland duct morphogenesis tissue morphogenesis anatomical structure morphogenesis mammary gland epithelium development morphogenesis of a branching structure multi-organism reproductive process morphogenesis of a branching epithelium cellular response to stimulus regulation of cellular process intracellular receptor signaling pathway response to stimulus response to lipid signaling hormone-mediated signaling pathway intracellular signal transduction cell communication cellular response to endogenous stimulus response to hormone response to steroid hormone androgen receptor signaling pathway signal transduction nuclear receptor-mediated steroid hormone signaling pathway cellular response to steroid hormone stimulus response to organic cyclic compound steroid hormone receptor signaling pathway cellular response to hormone stimulus regulation of biological process response to endogenous stimulus biological regulation cellular response to organic cyclic compound cellular response to chemical stimulus response to chemical cellular response to lipid nuclear receptor-mediated signaling pathway regulation of biosynthetic process positive regulation of biological process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process positive regulation of macromolecule biosynthetic process regulation of gene expression positive regulation of metabolic process biosynthetic process positive regulation of gene expression positive regulation of biosynthetic process regulation of macromolecule biosynthetic process metabolic process positive regulation of macromolecule metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular process lateral sprouting from an epithelium lateral sprouting involved in mammary gland duct morphogenesis cell-cell signaling fertilization single fertilization positive regulation of cellular component organization regulation of cellular component organization cellular component organization plasma membrane organization cellular component organization or biogenesis integrin biosynthetic process endomembrane system organization membrane organization positive regulation of integrin biosynthetic process regulation of integrin biosynthetic process cell surface receptor signaling pathway insulin-like growth factor receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway enzyme-linked receptor protein signaling pathway regulation of developmental process regulation of cell differentiation positive regulation of developmental process positive regulation of cell differentiation positive regulation of DNA-templated transcription RNA metabolic process positive regulation of miRNA transcription positive regulation of miRNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process miRNA transcription regulation of miRNA metabolic process regulation of nucleobase-containing compound metabolic process miRNA metabolic process regulation of RNA biosynthetic process positive regulation of nucleobase-containing compound metabolic process primary metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of DNA-templated transcription regulation of miRNA transcription embryo development ending in birth or egg hatching chordate embryonic development embryo development in utero embryonic development intracellular signaling cassette MAPK cascade positive regulation of cell communication positive regulation of signal transduction regulation of signal transduction positive regulation of response to stimulus positive regulation of insulin-like growth factor receptor signaling pathway regulation of insulin-like growth factor receptor signaling pathway regulation of signaling regulation of response to stimulus regulation of cell communication positive regulation of signaling positive regulation of DNA-binding transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of molecular function regulation of molecular function regulation of DNA-binding transcription factor activity estrogen receptor signaling pathway system process regulation of systemic arterial blood pressure circulatory system process regulation of blood pressure regulation of biological quality blood circulation response to estrogen cellular response to estrogen stimulus negative regulation of signaling negative regulation of biological process regulation of programmed cell death extrinsic apoptotic signaling pathway negative regulation of cell communication negative regulation of extrinsic apoptotic signaling pathway negative regulation of apoptotic signaling pathway negative regulation of cellular process negative regulation of response to stimulus negative regulation of programmed cell death regulation of apoptotic process cell death negative regulation of signal transduction regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway negative regulation of apoptotic process apoptotic process programmed cell death regulation of apoptotic signaling pathway protein localization regulation of localization cellular localization protein localization to cell periphery regulation of protein localization protein localization to plasma membrane localization within membrane regulation of protein localization to cell periphery protein localization to membrane localization regulation of cellular localization cellular macromolecule localization macromolecule localization regulation of protein localization to plasma membrane regulation of protein localization to membrane prostate gland epithelium morphogenesis prostate gland morphogenesis negative regulation of RNA biosynthetic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process multicellular organism growth developmental growth growth negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation regulation of epithelial cell proliferation epithelial cell proliferation negative regulation of epithelial cell proliferation positive regulation of transcription by RNA polymerase II seminiferous tubule development male somatic sex determination sex determination male sex determination somatic sex determination Leydig cell differentiation cellular component biogenesis organelle organization cellular component assembly organelle assembly membraneless organelle assembly cell development cell morphogenesis epithelial cell development epithelial cell morphogenesis morphogenesis of an epithelial fold positive regulation of cell population proliferation regulation of reproductive process regulation of epithelial cell proliferation involved in prostate gland development positive regulation of reproductive process positive regulation of epithelial cell proliferation epithelial cell proliferation involved in prostate gland development positive regulation of epithelial cell proliferation involved in prostate gland development regulation of intracellular signal transduction positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade regulation of growth regulation of developmental growth cellular response to testosterone stimulus response to ketone response to oxygen-containing compound cellular response to oxygen-containing compound response to testosterone cellular response to ketone anatomical structure formation involved in morphogenesis animal organ formation negative regulation of integrin biosynthetic process negative regulation of cellular component organization positive regulation of phosphorylation positive regulation of phosphorus metabolic process phosphorylation positive regulation of phosphate metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process regulation of phosphorus metabolic process regulation of phosphorylation phosphorus metabolic process positive regulation of transcription by RNA polymerase III transcription by RNA polymerase III regulation of transcription by RNA polymerase III organ growth prostate gland growth positive regulation of intracellular estrogen receptor signaling pathway regulation of intracellular estrogen receptor signaling pathway regulation of intracellular steroid hormone receptor signaling pathway positive regulation of intracellular steroid hormone receptor signaling pathway male genitalia morphogenesis genitalia development male anatomical structure morphogenesis male genitalia development genitalia morphogenesis mammary gland lobule development mammary gland alveolus development	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle cellular anatomical structure nucleoplasm organelle lumen organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle cellular anatomical structure nucleoplasm organelle lumen organelle nuclear lumen cytoplasm cytosol membraneless organelle intracellular membraneless organelle chromatin chromosome cell periphery plasma membrane membrane protein-containing complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001628	Zinc finger, nuclear hormone receptor-type	Domain
A	IPR001103	Androgen receptor	Family
A	IPR050200	Nuclear hormone receptor family NR3 subfamily	Family
A	IPR013088	Zinc finger, NHR/GATA-type	Homologous Superfamily
A	IPR000536	Nuclear hormone receptor, ligand-binding domain	Domain
A	IPR035500	Nuclear hormone receptor-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P10275	androgen insensitivity syndrome Kennedy disease prostate cancer breast cancer hypospadias 1, X-linked astrocytic tumor protoplasmic astrocytoma pilocytic astrocytoma breast carcinoma Bulbospinal neuronopathy, X-linked recessive hypertensive disorder childhood cerebral astrocytoma anaplastic astrocytoma juvenile pilocytic astrocytoma androgenetic alopecia androgen insensitivity syndrome Kennedy disease prostate cancer breast cancer hypospadias 1, X-linked astrocytic tumor protoplasmic astrocytoma pilocytic astrocytoma breast carcinoma Bulbospinal neuronopathy, X-linked recessive hypertensive disorder childhood cerebral astrocytoma anaplastic astrocytoma juvenile pilocytic astrocytoma androgenetic alopecia partial androgen insensitivity syndrome female infertility male infertility fibrillary astrocytoma prostate intraepithelial neoplasia gestational diabetes subependymal giant cell astrocytoma alopecia leukemia male breast carcinoma gemistocytic astrocytoma malignant mesothelioma glioblastoma hereditary angioedema psoriasis hypopituitarism spinal muscular atrophy inherited aplastic anemia alcohol withdrawal neurodegenerative disease pancreatic ductal adenocarcinoma cutaneous lupus erythematosus pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia depressive disorder Klinefelter syndrome astrocytoma (excluding glioblastoma) familial prostate carcinoma atypical teratoid rhabdoid tumor primitive neuroectodermal tumor prostate carcinoma medulloblastoma pseudohermaphroditism Noonan syndrome intellectual disability pancreatic intraductal papillary-mucinous carcinoma Diamond-Blackfan anemia large cell medulloblastoma aplastic anemia pituitary cancer endometriosis atopic eczema autism prostate adenocarcinoma malignant ependymoma hepatocellular carcinoma breast fibrocystic disease carcinoma hypogonadotropic hypogonadism cerebral astrocytoma schizophrenia complete androgen insensitivity syndrome osteosarcoma cryptorchidism interstitial cystitis pancreatic intraductal papillary-mucinous neoplasm diffuse astrocytoma polycystic ovary syndrome male reproductive system disease

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.