4OY2 | pdb_00004oy2

Crystal structure of TAF1-TAF7, a TFIID subcomplex

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Rap30/74 heterodimerisation domain-like	8054052	3000142	SCOP2B (2022-06-29)
B [auth C]	SCOP2B Superfamily	Rap30/74 heterodimerisation domain-like	8054052	3000142	SCOP2B (2022-06-29)
C [auth E]	SCOP2 Family	TFIID subunit, TAF1	8047288	4005550	SCOP2 (2022-06-29)
C [auth E]	SCOP2 Superfamily	Rap30/74 heterodimerisation domain-like	8054052	3000142	SCOP2 (2022-06-29)
D [auth B]	SCOP2B Superfamily	Rap30/74 heterodimerisation domain-like	8054051	3000142	SCOP2B (2022-06-29)
E [auth D]	SCOP2B Superfamily	Rap30/74 heterodimerisation domain-like	8054051	3000142	SCOP2B (2022-06-29)
F	SCOP2 Family	TFIID subunit, TAF7	8046281	4004997	SCOP2 (2022-06-29)
F	SCOP2 Superfamily	Rap30/74 heterodimerisation domain-like	8054051	3000142	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	TAFII55_N	e4oy2A1	A: beta complex topology	X: triple barrel (From Homology)	H: triple barrel	T: TFIID subunits TAF1-TAF7	F: TAFII55_N	ECOD (1.6)
A	DUF3591_2nd	e4oy2A2	A: alpha arrays	X: HTH	H: HTH	T: winged	F: DUF3591_2nd	ECOD (1.6)
B [auth C]	DUF3591_1st	e4oy2C2	A: beta complex topology	X: triple barrel (From Homology)	H: triple barrel	T: TFIID subunits TAF1-TAF7	F: DUF3591_1st	ECOD (1.6)
B [auth C]	DUF3591_2nd	e4oy2C1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: DUF3591_2nd	ECOD (1.6)
C [auth E]	DUF3591_1st	e4oy2E2	A: beta complex topology	X: triple barrel (From Homology)	H: triple barrel	T: TFIID subunits TAF1-TAF7	F: DUF3591_1st	ECOD (1.6)
C [auth E]	DUF3591_2nd	e4oy2E1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: DUF3591_2nd	ECOD (1.6)
D [auth B]	TAFII55_N	e4oy2B1	A: beta complex topology	X: triple barrel (From Homology)	H: triple barrel	T: TFIID subunits TAF1-TAF7	F: TAFII55_N	ECOD (1.6)
E [auth D]	TAFII55_N	e4oy2D1	A: beta complex topology	X: triple barrel (From Homology)	H: triple barrel	T: TFIID subunits TAF1-TAF7	F: TAFII55_N	ECOD (1.6)
F	TAFII55_N	e4oy2F1	A: beta complex topology	X: triple barrel (From Homology)	H: triple barrel	T: TFIID subunits TAF1-TAF7	F: TAFII55_N	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
D [auth B], E [auth D], F	PF04658	TAFII55 protein conserved region (TAFII55_N)	TAFII55 protein conserved region	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B [auth C], C [auth E]	Transcription initiation factor TFIID subunit 1	protein-lysine-acetyltransferase activity histone H4K12 acetyltransferase activity catalytic activity, acting on a protein protein N-acetyltransferase activity N-acetyltransferase activity acyltransferase activity histone H4 acetyltransferase activity transferase activity histone acetyltransferase activity acetyltransferase activity histone modifying activity acyltransferase activity, transferring groups other than amino-acyl groups catalytic activity N-acyltransferase activity protein-lysine-acetyltransferase activity histone H4K12 acetyltransferase activity catalytic activity, acting on a protein protein N-acetyltransferase activity N-acetyltransferase activity acyltransferase activity histone H4 acetyltransferase activity transferase activity histone acetyltransferase activity acetyltransferase activity histone modifying activity acyltransferase activity, transferring groups other than amino-acyl groups catalytic activity N-acyltransferase activity histone H3 acetyltransferase activity histone H3K56 acetyltransferase activity histone H3K122 acetyltransferase activity histone H4K8 acetyltransferase activity chromatin binding binding protein heterodimerization activity protein binding protein dimerization activity histone H3K4 acetyltransferase activity histone H3K9 acetyltransferase activity histone H3K14 acetyltransferase activity histone H3K18 acetyltransferase activity histone H2B acetyltransferase activity histone H2BK12 acetyltransferase activity histone H2AK9 acetyltransferase activity histone H2A acetyltransferase activity transcription factor binding TBP-class protein binding general transcription initiation factor binding histone H2AK5 acetyltransferase activity histone H4K5 acetyltransferase activity general transcription initiation factor activity RNA polymerase II general transcription initiation factor activity histone H2BK5 acetyltransferase activity molecular adaptor activity histone H3K27 acetyltransferase activity histone H4K16 acetyltransferase activity histone H3K36 acetyltransferase activity histone H3K23 acetyltransferase activity	transcription preinitiation complex assembly RNA metabolic process cellular component organization cellular component biogenesis protein-DNA complex organization RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process cellular component assembly transcription by RNA polymerase II protein-containing complex assembly cellular component organization or biogenesis transcription initiation at RNA polymerase II promoter transcription preinitiation complex assembly RNA metabolic process cellular component organization cellular component biogenesis protein-DNA complex organization RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process cellular component assembly transcription by RNA polymerase II protein-containing complex assembly cellular component organization or biogenesis transcription initiation at RNA polymerase II promoter protein-containing complex organization protein-DNA complex assembly primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process DNA-templated transcription initiation nucleic acid metabolic process biosynthetic process RNA polymerase II preinitiation complex assembly cellular process metabolic process macromolecule metabolic process regulation of cellular process positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process positive regulation of metabolic process regulation of RNA metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of transcription by RNA polymerase II regulation of biological process positive regulation of nucleobase-containing compound metabolic process biological regulation regulation of macromolecule metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process regulation of gene expression positive regulation of RNA biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol RNA polymerase II transcription regulator complex membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex nucleus membrane-enclosed lumen nuclear protein-containing complex transcription regulator complex transferase complex intracellular organelle lumen cellular anatomical structure intracellular anatomical structure cytoplasm cytosol RNA polymerase II transcription regulator complex membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex nucleus membrane-enclosed lumen nuclear protein-containing complex transcription regulator complex transferase complex intracellular organelle lumen intracellular organelle nucleoplasm catalytic complex intracellular membrane-bounded organelle transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen organelle RNA polymerase complex transcription factor TFIID complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen
D [auth B], E [auth D], F	Transcription initiation factor TFIID subunit 7	protein heterodimerization activity protein binding binding protein dimerization activity	transcription preinitiation complex assembly RNA metabolic process cellular component organization cellular component biogenesis protein-DNA complex organization RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process cellular component assembly transcription by RNA polymerase II protein-containing complex assembly cellular component organization or biogenesis transcription initiation at RNA polymerase II promoter transcription preinitiation complex assembly RNA metabolic process cellular component organization cellular component biogenesis protein-DNA complex organization RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process cellular component assembly transcription by RNA polymerase II protein-containing complex assembly cellular component organization or biogenesis transcription initiation at RNA polymerase II promoter protein-containing complex organization protein-DNA complex assembly primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process DNA-templated transcription initiation nucleic acid metabolic process biosynthetic process RNA polymerase II preinitiation complex assembly cellular process metabolic process macromolecule metabolic process regulation of cellular process positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process positive regulation of metabolic process regulation of RNA metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of transcription by RNA polymerase II regulation of biological process positive regulation of nucleobase-containing compound metabolic process biological regulation regulation of macromolecule metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process regulation of gene expression positive regulation of RNA biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process	RNA polymerase II transcription regulator complex membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transcription regulator complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm RNA polymerase II transcription regulator complex membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transcription regulator complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm catalytic complex intracellular membrane-bounded organelle transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen organelle RNA polymerase complex transcription factor TFIID complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B [auth C], C [auth E]	IPR040240	Transcription initiation factor TFIID subunit 1	Family
A, B [auth C], C [auth E]	IPR041670	Zinc knuckle	Domain
A, B [auth C], C [auth E]	IPR022591	Transcription initiation factor TFIID subunit 1, histone acetyltransferase domain	Domain
D [auth B], E [auth D], F	IPR037817	Transcription initiation factor TFIID subunit 7	Family
D [auth B], E [auth D], F	IPR006751	TAFII55 protein, conserved region	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.