4PCK | pdb_00004pck

Crystal structure of the P22S mutant of N-terminal CS domain of human Shq1

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	KOG3247	e4pckA1	A: beta sandwiches	X: HSP20-like	H: HSP20-like chaperones (From Topology)	T: HSP20-like chaperones	F: KOG3247	ECOD (1.6)
B	KOG3247	e4pckB1	A: beta sandwiches	X: HSP20-like	H: HSP20-like chaperones (From Topology)	T: HSP20-like chaperones	F: KOG3247	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.790	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)
B	2.60.40.790	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF21413	SHQ1-like, CS domain (SHQ1-like_CS)	SHQ1-like, CS domain	This domain is found at the N-terminal end of Protein SHQ1 homolog from humans and similar eukaryotic proteins. SHQ1 is a factor required for the biogenesis and assembly of H/ACA small nucleolar ribonucleoparticle (snoRNP), which are essential for ri ...	This domain is found at the N-terminal end of Protein SHQ1 homolog from humans and similar eukaryotic proteins. SHQ1 is a factor required for the biogenesis and assembly of H/ACA small nucleolar ribonucleoparticle (snoRNP), which are essential for ribosomal RNA and telomerase RNA processing and metabolism. This protein contains two domains: an N-terminal CS (named after CHORD-containing proteins and SGT1) or HSP20-like domain (represented by this entry), and a C-terminal region called the Shq1 domain (Pfam:PF04925). The CS domain folds into a compact anti-parallel beta-sandwich made of two beta-sheets with four and three beta-strands, respectively, and a short alpha-helix [1-3].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Protein SHQ1 homolog	unfolded protein binding protein binding binding	RNA localization to nucleus localization telomerase RNA localization macromolecule localization RNA localization to Cajal body telomerase RNA localization to Cajal body RNA localization ribonucleoprotein complex biogenesis box H/ACA snoRNP assembly protein-containing complex organization small nucleolar ribonucleoprotein complex assembly protein-RNA complex assembly cellular component organization cellular component biogenesis RNA localization to nucleus localization telomerase RNA localization macromolecule localization RNA localization to Cajal body telomerase RNA localization to Cajal body RNA localization ribonucleoprotein complex biogenesis box H/ACA snoRNP assembly protein-containing complex organization small nucleolar ribonucleoprotein complex assembly protein-RNA complex assembly cellular component organization cellular component biogenesis protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular process cellular component organization or biogenesis	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR007052	CS domain	Domain
A, B	IPR007009	Shq1, C-terminal domain	Domain
A, B	IPR048696	SHQ1-like, CS domain	Domain
A, B	IPR008978	HSP20-like chaperone	Homologous Superfamily
A, B	IPR039742	Protein Shq1	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q6PI26	exocrine pancreatic carcinoma lymphoplasmacytic lymphoma osteosarcoma gastric cancer malignant pancreatic neoplasm ovarian cancer gastric carcinoma medulloblastoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.