4PPH | pdb_00004pph

Crystal structure of conglutin gamma, a unique basic 7S globulin from lupine seeds

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4ppha_	All beta proteins	Acid proteases	Acid proteases	automated matches	automated matches	(Lupinus angustifolius ) [TaxId: 3871 ],	SCOPe (2.08)
B	d4pphb_	All beta proteins	Acid proteases	Acid proteases	automated matches	automated matches	(Lupinus angustifolius ) [TaxId: 3871 ],	SCOPe (2.08)
C	d4pphc_	All beta proteins	Acid proteases	Acid proteases	automated matches	automated matches	(Lupinus angustifolius ) [TaxId: 3871 ],	SCOPe (2.08)
D	d4pphd_	All beta proteins	Acid proteases	Acid proteases	automated matches	automated matches	(Lupinus angustifolius ) [TaxId: 3871 ],	SCOPe (2.08)
E	d4pphe_	All beta proteins	Acid proteases	Acid proteases	automated matches	automated matches	(Lupinus angustifolius ) [TaxId: 3871 ],	SCOPe (2.08)
F	d4pphf_	All beta proteins	Acid proteases	Acid proteases	automated matches	automated matches	(Lupinus angustifolius ) [TaxId: 3871 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	TAXi_C	e4pphA2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: acid protease	F: TAXi_C	ECOD (1.6)
A	TAXi_N	e4pphA1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: acid protease	F: TAXi_N	ECOD (1.6)
B	TAXi_C	e4pphB2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: acid protease	F: TAXi_C	ECOD (1.6)
B	TAXi_N	e4pphB1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: acid protease	F: TAXi_N	ECOD (1.6)
C	TAXi_C	e4pphC2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: acid protease	F: TAXi_C	ECOD (1.6)
C	TAXi_N	e4pphC1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: acid protease	F: TAXi_N	ECOD (1.6)
D	TAXi_C	e4pphD2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: acid protease	F: TAXi_C	ECOD (1.6)
D	TAXi_N	e4pphD1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: acid protease	F: TAXi_N	ECOD (1.6)
E	TAXi_C	e4pphE1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: acid protease	F: TAXi_C	ECOD (1.6)
E	TAXi_N	e4pphE2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: acid protease	F: TAXi_N	ECOD (1.6)
F	TAXi_C	e4pphF1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: acid protease	F: TAXi_C	ECOD (1.6)
F	TAXi_N	e4pphF2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: acid protease	F: TAXi_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.40.70.10	Mainly Beta	Beta Barrel	Cathepsin D, subunit A	domain 1	CATH (4.3.0)
B	2.40.70.10	Mainly Beta	Beta Barrel	Cathepsin D, subunit A	domain 1	CATH (4.3.0)
C	2.40.70.10	Mainly Beta	Beta Barrel	Cathepsin D, subunit A	domain 1	CATH (4.3.0)
D	2.40.70.10	Mainly Beta	Beta Barrel	Cathepsin D, subunit A	domain 1	CATH (4.3.0)
E	2.40.70.10	Mainly Beta	Beta Barrel	Cathepsin D, subunit A	domain 1	CATH (4.3.0)
F	2.40.70.10	Mainly Beta	Beta Barrel	Cathepsin D, subunit A	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF14541	Xylanase inhibitor C-terminal (TAXi_C)	Xylanase inhibitor C-terminal	This domain is found C-terminal in some aspartic proteinases and in xylanase inhibitors. The activity of these proteins is vital for plant-survival as xylanase produced by phytopathogens destroys plant cells. In TAXI-type inhibitors, this domain is i ...	This domain is found C-terminal in some aspartic proteinases and in xylanase inhibitors. The activity of these proteins is vital for plant-survival as xylanase produced by phytopathogens destroys plant cells. In TAXI-type inhibitors, this domain is important for the differences in xylanase specificity [1-3].	Domain
A, B, C, D, E A, B, C, D, E, F	PF14543	Xylanase inhibitor N-terminal (TAXi_N)	Xylanase inhibitor N-terminal	This domain is found N-terminal in some aspartic proteinases and in xylanase inhibitors. The activity of these proteins is vital for plant-survival as xylanase produced by phytopathogens destroys plant cells [1-3].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	Conglutin gamma	aspartic-type peptidase activity peptidase activity catalytic activity, acting on a protein hydrolase activity aspartic-type endopeptidase activity catalytic activity endopeptidase activity	proteolysis metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process	cellular anatomical structure extracellular region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR032861	Xylanase inhibitor, N-terminal	Domain
A, B, C, D, E A, B, C, D, E, F	IPR001461	Aspartic peptidase A1	Family
A, B, C, D, E A, B, C, D, E, F	IPR033121	Peptidase family A1 domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR021109	Aspartic peptidase domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR032799	Xylanase inhibitor, C-terminal	Domain
A, B, C, D, E A, B, C, D, E, F	IPR033868	Xylanase inhibitor I-like	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.