4UW1

X-ray crystal structure of human TNKS in complex with a small molecule inhibitor

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PARP	e4uw1A1	A: a+b complex topology	X: ADP-ribosylation (From Topology)	H: ADP-ribosylation (From Topology)	T: ADP-ribosylation	F: PARP	ECOD (1.6)
B	PARP	e4uw1B1	A: a+b complex topology	X: ADP-ribosylation (From Topology)	H: ADP-ribosylation (From Topology)	T: ADP-ribosylation	F: PARP	ECOD (1.6)
C	PARP	e4uw1C1	A: a+b complex topology	X: ADP-ribosylation (From Topology)	H: ADP-ribosylation (From Topology)	T: ADP-ribosylation	F: PARP	ECOD (1.6)
D	PARP	e4uw1D1	A: a+b complex topology	X: ADP-ribosylation (From Topology)	H: ADP-ribosylation (From Topology)	T: ADP-ribosylation	F: PARP	ECOD (1.6)
E	PARP	e4uw1E1	A: a+b complex topology	X: ADP-ribosylation (From Topology)	H: ADP-ribosylation (From Topology)	T: ADP-ribosylation	F: PARP	ECOD (1.6)
F	PARP	e4uw1F1	A: a+b complex topology	X: ADP-ribosylation (From Topology)	H: ADP-ribosylation (From Topology)	T: ADP-ribosylation	F: PARP	ECOD (1.6)
G	PARP	e4uw1G1	A: a+b complex topology	X: ADP-ribosylation (From Topology)	H: ADP-ribosylation (From Topology)	T: ADP-ribosylation	F: PARP	ECOD (1.6)
H	PARP	e4uw1H1	A: a+b complex topology	X: ADP-ribosylation (From Topology)	H: ADP-ribosylation (From Topology)	T: ADP-ribosylation	F: PARP	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.90.228.10	Alpha Beta	Alpha-Beta Complex	Phosphoenolpyruvate Carboxykinase	domain 3	CATH (4.3.0)
B	3.90.228.10	Alpha Beta	Alpha-Beta Complex	Phosphoenolpyruvate Carboxykinase	domain 3	CATH (4.3.0)
C	3.90.228.10	Alpha Beta	Alpha-Beta Complex	Phosphoenolpyruvate Carboxykinase	domain 3	CATH (4.3.0)
D	3.90.228.10	Alpha Beta	Alpha-Beta Complex	Phosphoenolpyruvate Carboxykinase	domain 3	CATH (4.3.0)
E	3.90.228.10	Alpha Beta	Alpha-Beta Complex	Phosphoenolpyruvate Carboxykinase	domain 3	CATH (4.3.0)
F	3.90.228.10	Alpha Beta	Alpha-Beta Complex	Phosphoenolpyruvate Carboxykinase	domain 3	CATH (4.3.0)
G	3.90.228.10	Alpha Beta	Alpha-Beta Complex	Phosphoenolpyruvate Carboxykinase	domain 3	CATH (4.3.0)
H	3.90.228.10	Alpha Beta	Alpha-Beta Complex	Phosphoenolpyruvate Carboxykinase	domain 3	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF00644	Poly(ADP-ribose) polymerase catalytic domain (PARP)	Poly(ADP-ribose) polymerase catalytic domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	TANKYRASE-1	protein binding binding histone binding pentosyltransferase activity catalytic activity, acting on a protein glycosyltransferase activity NAD+-protein ADP-ribosyltransferase activity transferase activity catalytic activity cation binding transition metal ion binding zinc ion binding ion binding metal ion binding protein binding binding histone binding pentosyltransferase activity catalytic activity, acting on a protein glycosyltransferase activity NAD+-protein ADP-ribosyltransferase activity transferase activity catalytic activity cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding nucleotidyltransferase activity transferase activity, transferring phosphorus-containing groups NAD+-protein poly-ADP-ribosyltransferase activity	regulation of maintenance of mitotic sister chromatid cohesion mitotic sister chromatid cohesion, telomeric negative regulation of maintenance of sister chromatid cohesion regulation of cellular component organization regulation of cellular process negative regulation of maintenance of mitotic sister chromatid cohesion mitotic sister chromatid cohesion regulation of maintenance of mitotic sister chromatid cohesion, telomeric negative regulation of biological process negative regulation of cell cycle maintenance of sister chromatid cohesion maintenance of mitotic sister chromatid cohesion, telomeric cellular component organization negative regulation of sister chromatid cohesion negative regulation of chromosome organization regulation of maintenance of mitotic sister chromatid cohesion mitotic sister chromatid cohesion, telomeric negative regulation of maintenance of sister chromatid cohesion regulation of cellular component organization regulation of cellular process negative regulation of maintenance of mitotic sister chromatid cohesion mitotic sister chromatid cohesion regulation of maintenance of mitotic sister chromatid cohesion, telomeric negative regulation of biological process negative regulation of cell cycle maintenance of sister chromatid cohesion maintenance of mitotic sister chromatid cohesion, telomeric cellular component organization negative regulation of sister chromatid cohesion negative regulation of chromosome organization maintenance of mitotic sister chromatid cohesion negative regulation of cellular process cellular component organization or biogenesis cell cycle regulation of cell cycle cell cycle process regulation of biological process negative regulation of cellular component organization regulation of cell cycle process biological regulation chromosome organization sister chromatid cohesion regulation of chromosome organization negative regulation of cell cycle process regulation of organelle organization negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric regulation of maintenance of sister chromatid cohesion organelle organization negative regulation of organelle organization regulation of sister chromatid cohesion cellular process positive regulation of organelle organization regulation of telomere maintenance positive regulation of cellular component organization positive regulation of biological process telomere organization regulation of primary metabolic process telomere maintenance via telomere lengthening nucleobase-containing compound metabolic process positive regulation of metabolic process positive regulation of telomere maintenance via telomere lengthening positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of cellular process positive regulation of telomere maintenance positive regulation of nucleobase-containing compound metabolic process primary metabolic process DNA metabolic process regulation of macromolecule metabolic process regulation of telomere maintenance via telomere lengthening nucleic acid metabolic process positive regulation of chromosome organization telomere maintenance positive regulation of DNA metabolic process metabolic process macromolecule metabolic process regulation of metabolic process regulation of DNA metabolic process RNA transport nitrogen compound transport transport nucleic acid transport mRNA transport establishment of localization localization establishment of RNA localization macromolecule localization RNA localization nucleobase-containing compound transport regulation of DNA biosynthetic process RNA-templated DNA biosynthetic process nucleic acid biosynthetic process regulation of biosynthetic process telomere maintenance via telomerase nucleobase-containing compound biosynthetic process macromolecule biosynthetic process regulation of telomere maintenance via telomerase biosynthetic process regulation of macromolecule biosynthetic process DNA biosynthetic process cell division protein localization establishment of protein localization cellular localization protein transport cellular macromolecule localization regulation of molecular function regulation of DNA binding regulation of binding negative regulation of binding negative regulation of molecular function negative regulation of telomeric DNA binding regulation of telomeric DNA binding negative regulation of DNA binding protein phosphorylation phosphorylation macromolecule modification peptidyl-amino acid modification phosphate-containing compound metabolic process peptidyl-threonine modification protein metabolic process protein modification process phosphorus metabolic process peptidyl-threonine phosphorylation organelle assembly microtubule cytoskeleton organization membraneless organelle assembly spindle assembly cellular component biogenesis cellular component assembly microtubule-based process cytoskeleton organization chromosome segregation spindle organization protein polyubiquitination protein ubiquitination post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal positive regulation of macromolecule biosynthetic process positive regulation of telomere maintenance via telomerase positive regulation of biosynthetic process positive regulation of DNA biosynthetic process peptidyl-serine modification peptidyl-serine phosphorylation protein localization to chromosome protein localization to organelle protein localization to chromosome, telomeric region mitotic cell cycle mitotic spindle organization mitotic cell cycle process microtubule cytoskeleton organization involved in mitosis negative regulation of telomere maintenance negative regulation of telomere maintenance via telomere lengthening negative regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of DNA metabolic process cellular response to stimulus cell surface receptor signaling pathway response to stimulus signaling cell communication signal transduction Wnt signaling pathway positive regulation of cell communication positive regulation of signal transduction regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway regulation of signal transduction positive regulation of response to stimulus positive regulation of Wnt signaling pathway positive regulation of canonical Wnt signaling pathway regulation of signaling regulation of Wnt signaling pathway regulation of response to stimulus regulation of cell communication positive regulation of signaling protein poly-ADP-ribosylation positive regulation of telomere capping telomere capping regulation of telomere capping positive regulation of DNA-templated transcription RNA metabolic process RNA biosynthetic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II gene expression positive regulation of RNA metabolic process regulation of gene expression positive regulation of RNA biosynthetic process regulation of DNA-templated transcription protein auto-ADP-ribosylation	membrane-bounded organelle intracellular anatomical structure nuclear membrane membrane nucleus intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope organelle membrane cytoplasm membrane-bounded organelle intracellular anatomical structure nuclear membrane membrane nucleus intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope organelle membrane cytoplasm cytosol protein-containing complex nuclear protein-containing complex nuclear pore membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen Golgi apparatus Golgi membrane bounding membrane of organelle intracellular membraneless organelle pericentriolar material centrosome microtubule organizing center cytoskeleton membraneless organelle microtubule cytoskeleton mitotic spindle spindle mitotic spindle pole spindle pole nuclear body chromosome chromosome, telomeric region chromosomal region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR050745	Multifunctional regulatory proteins	Family
A, B, C, D, E A, B, C, D, E, F, G, H	IPR036770	Ankyrin repeat-containing domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR012317	Poly(ADP-ribose) polymerase, catalytic domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR002110	Ankyrin repeat	Repeat
A, B, C, D, E A, B, C, D, E, F, G, H	IPR013761	Sterile alpha motif/pointed domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR001660	Sterile alpha motif domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F, G, H	Pharos: O95271	ovarian cancer Carcinoma in situ of fallopian tube dermatomyositis psoriasis epilepsy osteosarcoma Sjogren syndrome

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.