5CZF | pdb_00005czf

Crystal structure of the PaaA2-ParE2 antitoxin-toxin complex

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	EUF08786	e5czfA1	A: extended segments	X: ParE2-associated antitoxin 2 (PaaA2) (From Topology)	H: ParE2-associated antitoxin 2 (PaaA2) (From Topology)	T: ParE2-associated antitoxin 2 (PaaA2)	F: EUF08786	ECOD (1.6)
B	EUF08786	e5czfB1	A: extended segments	X: ParE2-associated antitoxin 2 (PaaA2) (From Topology)	H: ParE2-associated antitoxin 2 (PaaA2) (From Topology)	T: ParE2-associated antitoxin 2 (PaaA2)	F: EUF08786	ECOD (1.6)
C	ParE_toxin	e5czfC1	A: a+b two layers	X: RelE-like	H: RelE-like (From Topology)	T: RelE-like	F: ParE_toxin	ECOD (1.6)
D	ParE_toxin	e5czfD1	A: a+b two layers	X: RelE-like	H: RelE-like (From Topology)	T: RelE-like	F: ParE_toxin	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C	3.30.2310.20	Alpha Beta	2-Layer Sandwich	YaeB-like fold	RelE-like	CATH (4.3.0)
D	3.30.2310.20	Alpha Beta	2-Layer Sandwich	YaeB-like fold	RelE-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF21217	Stability determinant (PaaA2)	Stability determinant	-	Family
C, D	PF05016	ParE toxin of type II toxin-antitoxin system, parDE (ParE_toxin)	ParE toxin of type II toxin-antitoxin system, parDE	ParE is the toxin family of a type II toxin-antitoxin family. It is toxic towards DNA gyrase, but is neutralised by the antitoxin ParD. The family also encompasses RelE/ParE described in [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	PaaA2	molecular adaptor activity	-	-
C, D	Plasmid stabilization protein ParE	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR048851	Stability determinant domain	Domain
C, D	IPR007712	Toxin-antitoxin system, RelE/ParE toxin family	Family
C, D	IPR051803	Type II TA system RelE-like toxin	Family
C, D	IPR035093	Toxin-antitoxin system, RelE/ParE toxin domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.