5E6P | pdb_00005e6p

PlexinB2 cytoplasmic region/PDZ-RhoGEF PDZ domain complex

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	PDZ domain-like	8062278	3000388	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Plexin_cytopl_1st	e5e6pA1	A: alpha bundles	X: GTPase activation domain, GAP (From Topology)	H: GTPase activation domain, GAP (From Topology)	T: GTPase activation domain, GAP	F: Plexin_cytopl_1st	ECOD (1.6)
A	Plexin_cytopl_2nd	e5e6pA2	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: Plexin_cytopl_2nd	ECOD (1.6)
B	PDZ	e5e6pB1	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PDZ	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.506.10	Mainly Alpha	Orthogonal Bundle	GTPase Activation - p120GAP	domain 1	CATH (4.3.0)
A	3.10.20.90	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Phosphatidylinositol 3-kinase Catalytic Subunit	CATH (4.3.0)
B	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF20170	Plexin cytoplasmic RhoGTPase-binding domain (Plexin_RBD)	Plexin cytoplasmic RhoGTPase-binding domain	This entry represents the RhoGTPase-binding domain found in the cytoplasmic domain of plexins [1].	Domain
A	PF08337	Plexin cytoplasmic RasGAP domain (Plexin_cytopl)	Plexin cytoplasmic RasGAP domain	This family features the C-terminal regions of various plexins (e.g. Swiss:P51805). Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels [1,2]. The cytop ...	This family features the C-terminal regions of various plexins (e.g. Swiss:P51805). Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels [1,2]. The cytoplasmic region, which has been called a SEX domain in some members of this family [3], is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins [4]. This domain acts as a RasGAP domain [5].	Domain
B	PF00595	PDZ domain (PDZ)	PDZ domain	PDZ domains are found in diverse signaling proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Plexin-B2	molecular transducer activity transmembrane signaling receptor activity signaling receptor activity semaphorin receptor activity	developmental process multicellular organismal process nervous system development excitatory synapse assembly cellular component organization cellular component biogenesis multicellular organism development cell junction organization cellular component assembly cell junction assembly anatomical structure development cellular process synapse organization cellular component organization or biogenesis developmental process multicellular organismal process nervous system development excitatory synapse assembly cellular component organization cellular component biogenesis multicellular organism development cell junction organization cellular component assembly cell junction assembly anatomical structure development cellular process synapse organization cellular component organization or biogenesis synapse assembly system development neuroblast proliferation cell population proliferation cellular developmental process generation of neurons neurogenesis cell differentiation neural precursor cell proliferation head development central nervous system development animal organ development brain development positive regulation of nervous system development axonogenesis regulation of cellular process cell projection organization regulation of cell differentiation regulation of neurogenesis neuron projection development regulation of cell development positive regulation of developmental process cell projection morphogenesis neuron differentiation neuron projection morphogenesis positive regulation of cell projection organization regulation of biological process regulation of cell projection organization positive regulation of cell development positive regulation of multicellular organismal process regulation of neuron projection development regulation of cellular component organization positive regulation of cellular component organization regulation of developmental process plasma membrane bounded cell projection morphogenesis positive regulation of biological process cell development cell morphogenesis regulation of nervous system development positive regulation of cell differentiation regulation of axonogenesis positive regulation of neurogenesis regulation of multicellular organismal process positive regulation of axonogenesis regulation of anatomical structure morphogenesis positive regulation of cellular process regulation of multicellular organismal development plasma membrane bounded cell projection organization biological regulation axon development cell morphogenesis involved in neuron differentiation anatomical structure morphogenesis neuron development regulation of plasma membrane bounded cell projection organization regulation of cell motility neuron migration regulation of neuron migration regulation of locomotion regulation of cell migration cell migration cell motility locomotion positive regulation of neuron projection development regulation of cell shape regulation of cell morphogenesis regulation of biological quality embryonic epithelial tube formation chordate embryonic development tube formation embryo development epithelial tube formation tube morphogenesis primary neural tube formation embryo development ending in birth or egg hatching epithelial tube morphogenesis morphogenesis of embryonic epithelium epithelium development neural tube development tube development embryonic morphogenesis morphogenesis of an epithelium tissue development tissue morphogenesis neural tube closure neural tube formation anatomical structure formation involved in morphogenesis tube closure positive regulation of protein metabolic process positive regulation of translation positive regulation of macromolecule biosynthetic process regulation of primary metabolic process post-transcriptional regulation of gene expression positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process protein metabolic process regulation of biosynthetic process regulation of protein metabolic process primary metabolic process regulation of macromolecule metabolic process gene expression translation macromolecule biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of translation regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process cellular response to stimulus cell surface receptor signaling pathway response to stimulus semaphorin-plexin signaling pathway signaling cell communication signal transduction regulation of protein modification process regulation of protein phosphorylation regulation of phosphate metabolic process phosphate-containing compound metabolic process protein modification process phosphorus metabolic process protein phosphorylation phosphorylation macromolecule modification regulation of phosphorylation regulation of phosphorus metabolic process cell adhesion cell-cell adhesion cell-cell adhesion via plasma-membrane adhesion molecules homophilic cell adhesion via plasma membrane adhesion molecules regulation of molecular function regulation of catalytic activity regulation of hydrolase activity regulation of GTPase activity	cell periphery extracellular matrix cellular anatomical structure external encapsulating structure collagen-containing extracellular matrix plasma membrane membrane
B	Rho guanine nucleotide exchange factor 11	GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity molecular function activator activity nucleoside-triphosphatase regulator activity molecular function regulator activity guanyl-nucleotide exchange factor activity protein binding binding signaling receptor binding G protein-coupled receptor binding	multicellular organismal process system process muscle contraction muscle system process striated muscle contraction regulation of growth regulation of biological process regulation of cellular component organization regulation of cellular process biological regulation growth regulation of cell growth cell growth cellular component organization multicellular organismal process system process muscle contraction muscle system process striated muscle contraction regulation of growth regulation of biological process regulation of cellular component organization regulation of cellular process biological regulation growth regulation of cell growth cell growth cellular component organization cellular process cellular component organization or biogenesis establishment of cell polarity establishment or maintenance of cell polarity organelle organization actin cytoskeleton organization actin filament-based process cytoskeleton organization cellular response to stimulus regulation of signaling small GTPase-mediated signal transduction response to stimulus signaling regulation of small GTPase mediated signal transduction regulation of signal transduction intracellular signal transduction cell communication regulation of intracellular signal transduction regulation of response to stimulus intracellular signaling cassette regulation of cell communication signal transduction positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process positive regulation of nucleobase-containing compound metabolic process primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process G protein-coupled receptor signaling pathway Rho protein signal transduction	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR002909	IPT domain	Domain
A	IPR016201	PSI domain	Domain
A	IPR014756	Immunoglobulin E-set	Homologous Superfamily
A	IPR008936	Rho GTPase activation protein	Homologous Superfamily
A	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
A	IPR002165	Plexin repeat	Repeat
A	IPR041019	Plexin, TIG domain 1	Domain
A	IPR031148	Plexin family	Family
A	IPR046800	Plexin, cytoplasmic RhoGTPase-binding domain	Domain
A	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A	IPR013548	Plexin, cytoplasmic RasGAP domain	Domain
A	IPR036352	Sema domain superfamily	Homologous Superfamily
A	IPR001627	Sema domain	Domain
B	IPR016137	RGS domain	Domain
B	IPR001849	Pleckstrin homology domain	Domain
B	IPR036305	RGS domain superfamily	Homologous Superfamily
B	IPR000219	Dbl homology domain	Domain
B	IPR011993	PH-like domain superfamily	Homologous Superfamily
B	IPR037803	Rho guanine nucleotide exchange factor 11, PH domain	Domain
B	IPR041020	ARHGEF1-like, PH domain	Domain
B	IPR037889	Rho guanine nucleotide exchange factor 11, RGS domain	Domain
B	IPR015212	Regulator of G protein signalling-like domain	Domain
B	IPR044926	RGS, subdomain 2	Homologous Superfamily
B	IPR036034	PDZ superfamily	Homologous Superfamily
B	IPR035899	Dbl homology (DH) domain superfamily	Homologous Superfamily
B	IPR001478	PDZ domain	Domain