5GJV | pdb_00005gjv

Structure of the mammalian voltage-gated calcium channel Cav1.1 complex at near atomic resolution

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	EF-hand_7_6	e5gjvA6	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_6	ECOD (1.6)
A	Ion_trans	e5gjvA1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: Ion_trans	ECOD (1.6)
A	Ca_chan_IQ	e5gjvA3	A: extended segments	X: Voltage gated calcium channel IQ domain (From Topology)	H: Voltage gated calcium channel IQ domain (From Topology)	T: Voltage gated calcium channel IQ domain	F: Ca_chan_IQ	ECOD (1.6)
C	Guanylate_kin	e5gjvC1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Guanylate_kin	ECOD (1.6)
E [auth F]	KOG2353	e5gjvF2	A: a+b three layers	X: Putative sensor histidine kinase domain (From Topology)	H: Putative sensor histidine kinase domain (From Topology)	T: Putative sensor histidine kinase domain	F: KOG2353	ECOD (1.6)
E [auth F]	VWA	e5gjvF1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: vWA-like	F: VWA	ECOD (1.6)
B	VGCC_beta4Aa_N,SH3_1_2	e5gjvB1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: VGCC_beta4Aa_N,SH3_1_2	ECOD (1.6)
D [auth E]	Claudin_2	e5gjvE1	A: alpha bundles	X: Bromodomain-like	H: Claudin (From Topology)	T: Claudin	F: Claudin_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
B	2.30.30.40	Mainly Beta	Roll	SH3 type barrels.	SH3 Domains	CATH (4.3.0)
D [auth E]	1.20.140.150	Mainly Alpha	Up-down Bundle	Butyryl-CoA Dehydrogenase, subunit A	domain 3	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF08763	Voltage gated calcium channel IQ domain (Ca_chan_IQ)	Voltage gated calcium channel IQ domain	Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin [1]. ...	Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin [1]. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).	Domain
A	PF16905	Voltage-dependent L-type calcium channel, IQ-associated (GPHH)	Voltage-dependent L-type calcium channel, IQ-associated	-	Family
A	PF08016	Polycystin cation channel (PKD_channel)	Polycystin cation channel	-	Family
A	PF00520	Ion transport protein (Ion_trans)	Ion transport protein	-	Family
C	PF00625	Guanylate kinase (Guanylate_kin)	Guanylate kinase		Domain
E [auth F]	PF08399	VWA N-terminal (VWA_N)	VWA N-terminal	-	Family
E [auth F]	PF00092	von Willebrand factor type A domain (VWA)	von Willebrand factor type A domain		Domain
E [auth F]	PF08473	Neuronal voltage-dependent calcium channel alpha 2acd (VGCC_alpha2)	Neuronal voltage-dependent calcium channel alpha 2acd	-	Family
B	PF12052	Voltage gated calcium channel subunit beta domain 4Aa N terminal (VGCC_beta4Aa_N)	Voltage gated calcium channel subunit beta domain 4Aa N terminal	The beta subunit of voltage gated calcium channels is coded for by four genes 1-4. Gene 4 can produce two types of beta4A domain (beta4Aa and beta4Ab) according to how the gene splicing is carried out. This family is part of the beta4Aa N terminal do ...	The beta subunit of voltage gated calcium channels is coded for by four genes 1-4. Gene 4 can produce two types of beta4A domain (beta4Aa and beta4Ab) according to how the gene splicing is carried out. This family is part of the beta4Aa N terminal domain. It is made up of an alpha helix and a beta strand. It is thought to regulate the channel properties through protein-protein interactions with non Ca channel proteins. [1]	Domain
D [auth E]	PF13903	PMP-22/EMP/MP20/Claudin tight junction (Claudin_2)	PMP-22/EMP/MP20/Claudin tight junction	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Voltage-dependent L-type calcium channel subunit alpha-1S	protein binding binding transmembrane transporter binding calcium channel activity monoatomic cation transmembrane transporter activity voltage-gated calcium channel activity gated channel activity monoatomic ion channel activity voltage-gated channel activity voltage-gated monoatomic ion channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity protein binding binding transmembrane transporter binding calcium channel activity monoatomic cation transmembrane transporter activity voltage-gated calcium channel activity gated channel activity monoatomic ion channel activity voltage-gated channel activity voltage-gated monoatomic ion channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity high voltage-gated calcium channel activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity calmodulin binding cation binding ion binding metal ion binding small molecule binding	import into cell calcium ion transmembrane import into cytosol transport monoatomic ion transmembrane transport import across plasma membrane inorganic ion transmembrane transport establishment of localization inorganic cation import across plasma membrane calcium ion transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization calcium ion import across plasma membrane import into cell calcium ion transmembrane import into cytosol transport monoatomic ion transmembrane transport import across plasma membrane inorganic ion transmembrane transport establishment of localization inorganic cation import across plasma membrane calcium ion transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization calcium ion import across plasma membrane inorganic ion import across plasma membrane monoatomic ion transport cellular process calcium ion import calcium ion import into cytosol monoatomic cation transport calcium ion transmembrane transport regulation of localization cellular localization regulation of cellular process inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process negative regulation of biological process calcium ion homeostasis negative regulation of sequestering of calcium ion maintenance of location in cell intracellular monoatomic cation homeostasis monoatomic ion homeostasis negative regulation of cellular process intracellular chemical homeostasis monoatomic cation homeostasis regulation of sequestering of calcium ion intracellular monoatomic ion homeostasis regulation of biological process sequestering of calcium ion biological regulation maintenance of location release of sequestered calcium ion into cytosol cellular homeostasis chemical homeostasis multicellular organismal process system process muscle contraction muscle system process regulation of calcium ion transmembrane transporter activity regulation of calcium ion transport regulation of release of sequestered calcium ion into cytosol regulation of monoatomic ion transport regulation of cation channel activity regulation of molecular function regulation of transmembrane transport regulation of transmembrane transporter activity regulation of monoatomic ion transmembrane transport regulation of transporter activity regulation of calcium ion transmembrane transport regulation of metal ion transport regulation of monoatomic ion transmembrane transporter activity regulation of transport regulation of ryanodine-sensitive calcium-release channel activity regulation of monoatomic cation transmembrane transport cellular response to nitrogen compound cellular response to stimulus response to stimulus cellular response to caffeine response to nitrogen compound response to purine-containing compound response to alkaloid cellular response to chemical stimulus response to chemical cellular response to alkaloid cellular response to purine-containing compound response to caffeine regulation of system process positive regulation of biological process regulation of muscle system process regulation of muscle contraction positive regulation of muscle contraction positive regulation of multicellular organismal process regulation of multicellular organismal process	protein-containing complex plasma membrane protein complex sarcolemma voltage-gated calcium channel complex plasma membrane membrane membrane protein complex cation channel complex transporter complex cell periphery cellular anatomical structure transmembrane transporter complex T-tubule L-type voltage-gated calcium channel complex protein-containing complex plasma membrane protein complex sarcolemma voltage-gated calcium channel complex plasma membrane membrane membrane protein complex cation channel complex transporter complex cell periphery cellular anatomical structure transmembrane transporter complex T-tubule L-type voltage-gated calcium channel complex calcium channel complex monoatomic ion channel complex
C	Voltage-dependent L-type calcium channel subunit beta-1	calcium channel activity monoatomic cation transmembrane transporter activity voltage-gated calcium channel activity gated channel activity monoatomic ion channel activity voltage-gated channel activity voltage-gated monoatomic ion channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity calcium channel activity monoatomic cation transmembrane transporter activity voltage-gated calcium channel activity gated channel activity monoatomic ion channel activity voltage-gated channel activity voltage-gated monoatomic ion channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity	transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization calcium ion transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport calcium ion transmembrane transport transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization calcium ion transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport calcium ion transmembrane transport multicellular organismal process regulation of biological process system process regulation of system process biological regulation positive regulation of biological process muscle contraction muscle system process regulation of muscle system process regulation of muscle contraction positive regulation of muscle contraction positive regulation of multicellular organismal process regulation of multicellular organismal process	protein-containing complex plasma membrane protein complex sarcolemma voltage-gated calcium channel complex plasma membrane membrane membrane protein complex cation channel complex transporter complex cell periphery cellular anatomical structure transmembrane transporter complex T-tubule L-type voltage-gated calcium channel complex protein-containing complex plasma membrane protein complex sarcolemma voltage-gated calcium channel complex plasma membrane membrane membrane protein complex cation channel complex transporter complex cell periphery cellular anatomical structure transmembrane transporter complex T-tubule L-type voltage-gated calcium channel complex calcium channel complex monoatomic ion channel complex
E [auth F]	Voltage-dependent calcium channel subunit alpha-2/delta-1	calcium channel activity monoatomic cation transmembrane transporter activity channel regulator activity monoatomic ion channel activity ion channel regulator activity calcium channel regulator activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity molecular function regulator activity monoatomic ion transmembrane transporter activity transporter activity calcium channel activity monoatomic cation transmembrane transporter activity channel regulator activity monoatomic ion channel activity ion channel regulator activity calcium channel regulator activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity molecular function regulator activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transporter regulator activity transmembrane transporter activity cation binding ion binding binding metal ion binding small molecule binding voltage-gated calcium channel activity gated channel activity voltage-gated channel activity voltage-gated monoatomic ion channel activity voltage-gated monoatomic cation channel activity	import into cell calcium ion transmembrane import into cytosol transport monoatomic ion transmembrane transport import across plasma membrane inorganic ion transmembrane transport establishment of localization inorganic cation import across plasma membrane calcium ion transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization calcium ion import across plasma membrane import into cell calcium ion transmembrane import into cytosol transport monoatomic ion transmembrane transport import across plasma membrane inorganic ion transmembrane transport establishment of localization inorganic cation import across plasma membrane calcium ion transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization calcium ion import across plasma membrane inorganic ion import across plasma membrane monoatomic ion transport cellular process calcium ion import calcium ion import into cytosol monoatomic cation transport calcium ion transmembrane transport	protein-containing complex plasma membrane protein complex sarcolemma voltage-gated calcium channel complex plasma membrane membrane membrane protein complex cation channel complex transporter complex cell periphery cellular anatomical structure transmembrane transporter complex T-tubule L-type voltage-gated calcium channel complex protein-containing complex plasma membrane protein complex sarcolemma voltage-gated calcium channel complex plasma membrane membrane membrane protein complex cation channel complex transporter complex cell periphery cellular anatomical structure transmembrane transporter complex T-tubule L-type voltage-gated calcium channel complex calcium channel complex monoatomic ion channel complex
B	Voltage-dependent L-type calcium channel subunit beta-1	calcium channel activity monoatomic cation transmembrane transporter activity voltage-gated calcium channel activity gated channel activity monoatomic ion channel activity voltage-gated channel activity voltage-gated monoatomic ion channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity calcium channel activity monoatomic cation transmembrane transporter activity voltage-gated calcium channel activity gated channel activity monoatomic ion channel activity voltage-gated channel activity voltage-gated monoatomic ion channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity	transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization calcium ion transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport calcium ion transmembrane transport transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization calcium ion transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport calcium ion transmembrane transport multicellular organismal process regulation of biological process system process regulation of system process biological regulation positive regulation of biological process muscle contraction muscle system process regulation of muscle system process regulation of muscle contraction positive regulation of muscle contraction positive regulation of multicellular organismal process regulation of multicellular organismal process	protein-containing complex plasma membrane protein complex sarcolemma voltage-gated calcium channel complex plasma membrane membrane membrane protein complex cation channel complex transporter complex cell periphery cellular anatomical structure transmembrane transporter complex T-tubule L-type voltage-gated calcium channel complex protein-containing complex plasma membrane protein complex sarcolemma voltage-gated calcium channel complex plasma membrane membrane membrane protein complex cation channel complex transporter complex cell periphery cellular anatomical structure transmembrane transporter complex T-tubule L-type voltage-gated calcium channel complex calcium channel complex monoatomic ion channel complex
D [auth E]	Voltage-dependent calcium channel gamma-1 subunit	calcium channel activity monoatomic cation transmembrane transporter activity channel regulator activity monoatomic ion channel activity ion channel regulator activity calcium channel regulator activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity molecular function regulator activity monoatomic ion transmembrane transporter activity transporter activity calcium channel activity monoatomic cation transmembrane transporter activity channel regulator activity monoatomic ion channel activity ion channel regulator activity calcium channel regulator activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity molecular function regulator activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transporter regulator activity transmembrane transporter activity voltage-gated calcium channel activity gated channel activity voltage-gated channel activity voltage-gated monoatomic ion channel activity voltage-gated monoatomic cation channel activity	transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization calcium ion transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport calcium ion transmembrane transport transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization calcium ion transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport calcium ion transmembrane transport regulation of calcium ion transport regulation of localization regulation of cellular process regulation of monoatomic ion transmembrane transport regulation of calcium ion transmembrane transport regulation of calcium ion transmembrane transport via high voltage-gated calcium channel calcium ion transmembrane transport via high voltage-gated calcium channel regulation of metal ion transport regulation of biological process regulation of transport regulation of monoatomic ion transport biological regulation regulation of transmembrane transport regulation of monoatomic cation transmembrane transport multicellular organismal process system process regulation of system process positive regulation of biological process muscle contraction muscle system process regulation of muscle system process regulation of muscle contraction positive regulation of muscle contraction positive regulation of multicellular organismal process regulation of multicellular organismal process	protein-containing complex plasma membrane protein complex sarcolemma voltage-gated calcium channel complex plasma membrane membrane membrane protein complex cation channel complex transporter complex cell periphery cellular anatomical structure transmembrane transporter complex T-tubule L-type voltage-gated calcium channel complex protein-containing complex plasma membrane protein complex sarcolemma voltage-gated calcium channel complex plasma membrane membrane membrane protein complex cation channel complex transporter complex cell periphery cellular anatomical structure transmembrane transporter complex T-tubule L-type voltage-gated calcium channel complex calcium channel complex monoatomic ion channel complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR005821	Ion transport domain	Domain
A	IPR005446	Voltage-dependent calcium channel, L-type, alpha-1 subunit	Family
A	IPR014873	Voltage-dependent calcium channel, alpha-1 subunit, IQ domain	Domain
A	IPR050599	Voltage-dependent calcium channel alpha-1 subunit	Family
A	IPR005450	Voltage-dependent calcium channel, L-type, alpha-1S subunit	Family
A	IPR002077	Voltage-dependent calcium channel, alpha-1 subunit	Family
A	IPR031688	Voltage-gated calcium channel subunit alpha, C-terminal	Domain
A	IPR031649	Voltage-dependent L-type calcium channel, IQ-associated domain	Domain
A	IPR027359	Voltage-dependent channel domain superfamily	Homologous Superfamily
C	IPR001452	SH3 domain	Domain
C	IPR008145	Guanylate kinase/L-type calcium channel beta subunit	Domain
C	IPR036028	SH3-like domain superfamily	Homologous Superfamily
C	IPR005443	Voltage-dependent calcium channel, L-type, beta-1 subunit	Family
C	IPR046937	Voltage-dependent L-type calcium channel subunit beta-1-4, N-terminal A domain	Domain
C	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
C	IPR000584	Voltage-dependent calcium channel, L-type, beta subunit	Family
E [auth F]	IPR051173	Voltage-dependent calcium channel subunit alpha-2/delta	Family
E [auth F]	IPR013680	Voltage-dependent calcium channel, alpha-2/delta subunit, conserved region	Domain
E [auth F]	IPR013608	VWA N-terminal	Domain
E [auth F]	IPR002035	von Willebrand factor, type A	Domain
E [auth F]	IPR036465	von Willebrand factor A-like domain superfamily	Homologous Superfamily
B	IPR001452	SH3 domain	Domain
B	IPR008145	Guanylate kinase/L-type calcium channel beta subunit	Domain
B	IPR036028	SH3-like domain superfamily	Homologous Superfamily
B	IPR005443	Voltage-dependent calcium channel, L-type, beta-1 subunit	Family
B	IPR046937	Voltage-dependent L-type calcium channel subunit beta-1-4, N-terminal A domain	Domain
B	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
B	IPR000584	Voltage-dependent calcium channel, L-type, beta subunit	Family
D [auth E]	IPR005421	Voltage-dependent calcium channel, gamma-1 subunit	Family
D [auth E]	IPR004031	PMP-22/EMP/MP20/Claudin	Family
D [auth E]	IPR008368	Voltage-dependent calcium channel, gamma subunit	Family

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C, D [auth E], E [auth F]	OPM	Transmembrane	Alpha-helical polytopic	Ion channel (VIC) superfamily	Voltage-sensitive calcium channel

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C, D [auth E], E [auth F]	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B, C, D [auth E], E [auth F]	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B, C, D [auth E], E [auth F]	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Channels: Calcium Ion-Selective	Ca_V1.1 L-type voltage-gated calcium channel